DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and MST1R

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:XP_005265227.2 Gene:MST1R / 4486 HGNCID:7381 Length:1401 Species:Homo sapiens


Alignment Length:739 Identity:195/739 - (26%)
Similarity:295/739 - (39%) Gaps:204/739 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   480 KNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINVHLVHG------------RPENTSCELKVKSR 532
            ::|.||..:|      |..:|:    ||:.:...||...            ..|:..||.::..:
Human   768 EDPVVLSISP------NCGYIN----SHITICGQHLTSAWHLVLSFHDGLRAVESRQCERQLPEQ 822

  Fly   533 SQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYC-PDHVCDPLEELNPM 596
             |.|...:|..:..:  |...|..|.  ||..:|      |..:|..|:. |.|  .|...|.|:
Human   823 -QLCRLPEYVVRDPQ--GWVAGNLSA--RGDGAA------GFTLPGFRFLPPPH--PPSANLVPL 874

  Fly   597 ACPQ---------------DCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPK 646
            . |:               ||......||..|.....||           |...|...|..:..:
Human   875 K-PEEHAIKFEYIGLGAVADCVGINVTVGGESCQHEFRG-----------DMVVCPLPPSLQLGQ 927

  Fly   647 MKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLL 711
            ...|.:...:.|...|..|.|..|...|  ...|||:|                 .|||.::..|
Human   928 DGAPLQVCVDGECHILGRVVRPGPDGVP--QSTLLGIL-----------------LPLLLLVAAL 973

  Fly   712 CLLIA-----QRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESG----------- 760
            ...:.     :||.|........:.:..:.|      |...|..|.||..:.||           
Human   974 ATALVFSYWWRRKQLVLPPNLNDLASLDQTA------GATPLPILYSGSDYRSGLALPAIDGLDS 1032

  Fly   761 ----------DAKWE-----FPREKLQL-------------------------DTVLGEGEFGQV 785
                      |::.|     ..:|.:||                         |.|:|:|.||.|
Human  1033 TTCVHGASFSDSEDESCVPLLRKESIQLRDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVV 1097

  Fly   786 LKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEA-PLL 849
            ..|...:.|  ......|:|.|.:.:...:..|.|.|..|::.::||||:.|:|.....|. |.:
Human  1098 YHGEYIDQA--QNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHV 1160

  Fly   850 IIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAA 914
            ::.|..:|.|..::|..::            .| .||.:::|..|:.:||.||:|.|.|||||||
Human  1161 LLPYMCHGDLLQFIRSPQR------------NP-TVKDLISFGLQVARGMEYLAEQKFVHRDLAA 1212

  Fly   915 RNVLLADGKICKISDFGLTRDVYEDDAY-LKRSRD-RVPVKWMAPESLADHVYTSKSDVWSFGVL 977
            ||.:|.:....|::||||.||:.:.:.| :::.|. |:||||||.|||..:.:|:||||||||||
Human  1213 RNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVL 1277

  Fly   978 CWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEF 1042
            .|||:|.||.||..|.|.:|...|..|.|:.:||.|.:::|.:::.||..:|..||:|:.|..|.
Human  1278 LWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEV 1342

  Fly  1043 EK----LLGNNAKYIDLETNAVSNPLYCGDDSALITTELGEPESLQHLWSPPKIAYDIHDQATSY 1103
            |:    |||::  |:.|                        |.:..:|           ..:||:
Human  1343 EQIVSALLGDH--YVQL------------------------PATYMNL-----------GPSTSH 1370

  Fly  1104 DQS-EEEMPVTSTAPPGYDLPRPL 1126
            :.: ..|.|..|..|.....||||
Human  1371 EMNVRPEQPQFSPMPGNVRRPRPL 1394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 111/310 (36%)
MST1RXP_005265227.2 Sema_RON 27..523 CDD:200540
PSI 526..568 CDD:396154
IPT_plexin_repeat1 569..683 CDD:238585
IPT_plexin_repeat2 684..768 CDD:238584 195/739 (26%)
IPT 769..860 CDD:214657 24/111 (22%)
PTKc_Met_Ron 1087..1348 CDD:270649 105/275 (38%)
Blue background indicates that the domain is not in the aligned region.

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