Protein Alignment Ret and Blk

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_006252250.1
• Gene: Blk / 364403
• RGDID: 1308859
• Length: 554
• Species: Rattus norvegicus
• Alignment Length: 283
• Identity: 100/283 - (35%)
• Similarity: 155/283 - (54%)
• Gaps: 26/283 - (9%)

  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            :||.||:.|:|...||.|:||:|..|:      ......||:|.||:|:.|.|  |.|.|..:::
  Rat   282 EWEIPRQSLKLVRKLGSGQFGEVWMGY------YKNNMKVAIKTLKEGTMSPE--AFLGEANVMK 338

  Fly   828 EVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTF 891
            .:.|..:::|....|  ..|:.|: ||...|.|..:|:            .|....:::..::..
  Rat   339 TLQHERLVRLYAVVT--REPIYIVTEYMARGCLLDFLK------------TDEGSRLSLPRLIDM 389

  Fly   892 AWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMA 956
            :.|:.:||||:..:..:||||.|.|:|:::...|||:||||.|.:  |..|..:...:.|:||.|
  Rat   390 SAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARII--DSEYTAQEGAKFPIKWTA 452

  Fly   957 PESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVY-SI 1020
            ||::...|:|.|:||||||||..|::|.|..||||::...:...|:.||||..||.|...:| .:
  Rat   453 PEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYHDV 517

  Fly  1021 VRTCWADEPNGRPSFKFLASEFE 1043
            :..||...|..||:|:||.|..|
  Rat   518 ITECWRGRPEERPTFEFLQSVLE 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	96/276 (35%)
Blk	XP_006252250.1	SH3	111..164	CDD:473055
		SH2	169..268	CDD:472789
		Protein Kinases, catalytic domain	282..545	CDD:473864	100/283 (35%)