DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and FLT4

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:XP_011532780.1 Gene:FLT4 / 2324 HGNCID:3767 Length:1440 Species:Homo sapiens


Alignment Length:1298 Identity:314/1298 - (24%)
Similarity:504/1298 - (38%) Gaps:351/1298 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 RMEDNRLASDYLYSLEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPDHELLN---- 119
            |:|....||.|                  :::| |:..|     |:      ::||..|:|    
Human   196 RIEGTTAASSY------------------VFVR-DFEQP-----FI------NKPDTLLVNRKDA 230

  Fly   120 ------VSHLSLEVTPQPLEEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAA 178
                  ||...|.||   |....|.|     |...|..:.:..   |......|:|..||     
Human   231 MWVPCLVSIPGLNVT---LRSQSSVL-----WPDGQEVVWDDR---RGMLVSTPLLHDAL----- 279

  Fly   179 KYLCPHVSLEYSLNAGSSHFV-------LKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTV-- 234
                   .|:.....|...|:       :..|.||..|.|....|..|   .|: :..:.|||  
Human   280 -------YLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSLELL---VGE-KLVLNCTVWA 333

  Fly   235 -------------------------KLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFDFYLE 274
                                     :.|.:...:.|.||.|..:.::|.|..:.::::....:.|
Human   334 EFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRE 398

  Fly   275 QPYFQADEEAGKKVIYVDKDTLEANA--HLV-----YAVHNDSHGLFRPDCHAYEADHTGRPHTI 332
            .......|.....|.::....|||.|  .||     .|.:......:..|..|....|:  ||.:
Human   399 STEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHS--PHAL 461

  Fly   333 VSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLS---KLHESEQELP--- 391
            |..::..:..|.:              |:.....|.....|:...:.::   ::||.|...|   
Human   462 VLKEVTEASTGTY--------------TLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIY 512

  Fly   392 -----QA---------LPLRARQH-------RIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSA 435
                 ||         |||..:.|       ::|.......... :.|.|...|:        .|
Human   513 SRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQ-QDLMPQCRDW--------RA 568

  Fly   436 ASNFRVVQPDSFLDL-------------------MRLRSIRFDIVEDKLGA------FGITS-TS 474
            .:....|.|...||.                   ..:.::...:|.:|:|.      |.:|: ..
Human   569 VTTQDAVNPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPD 633

  Fly   475 GIVFVKNP--QVLEEAPETIYFLNVTWIDQQRLSHVR-----VINVHLVHGRPENTSCELKVKSR 532
            |......|  ::||..|    .|.....|..:..|:|     :..:|..||.|....|:......
Human   634 GFTIESKPSEELLEGQP----VLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFA 694

  Fly   533 SQTCAQIKYQSQCVRYCGLA----------TGGGSC--QWRGSNSAMFGTRYGS--CVPESRYCP 583
            :...|.::..:...|:..|:          .|...|  |.|.|:......:|.|  .:...|...
Human   695 TPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQ 759

  Fly   584 D------HVCDPLEELNPMACPQDCTPAGRIVGPHSSN----ENKRGIYSASGTCICEDNGKCSC 638
            :      :|.|.||    |.|        .:.|.|:.:    :::|.:...||..:.:.|.|.|.
Human   760 NLTDLLVNVSDSLE----MQC--------LVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSI 812

  Fly   639 APLDEEPK---MKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVI 700
            ..:.||..   :......|....:...:.| .|:.....::..:|:|...:|.|       |:|:
Human   813 QRVREEDAGRYLCSVCNAKGCVNSSASVAV-EGSEDKGSMEIVILVGTGVIAVF-------FWVL 869

  Fly   701 TCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDA-KW 764
                  :||:.|.:        ||.....:.|.....:.:.|.     :||:....:.|.|| :|
Human   870 ------LLLIFCNM--------RRPAHADIKTGYLSIIMDPGE-----VPLEEQCEYLSYDASQW 915

  Fly   765 EFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV 829
            |||||:|.|..|||.|.||:|::..|..|.......||||||||:|:.:.|:.||:||.::|..:
Human   916 EFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHI 980

  Fly   830 -SHPNVIKLLGACTSSEAPLL-IIEYARYGSLRSYLRLSR-------------------KIECAG 873
             :|.||:.||||||..:.||: |:|:.:||:|.::||..|                   .:|.|.
Human   981 GNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELAR 1045

  Fly   874 VD-----------FA-----DG---------------VEPVNVKMVLTFAWQICKGMAYLSELKL 907
            :|           ||     :|               :.|:.::.::.:::|:.:||.:|:..|.
Human  1046 LDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKC 1110

  Fly   908 VHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVW 972
            :||||||||:||::..:.||.||||.||:|:|..|:::...|:|:|||||||:.|.|||::||||
Human  1111 IHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVW 1175

  Fly   973 SFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFK 1036
            |||||.||:.:||||||||: ..:.....|:.|.||..||..:.|:..|:..||:.:|..||:| 
Human  1176 SFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAF- 1239

  Fly  1037 FLASEFEKLLGN--NAKYIDLETNAVSNPLYC-----GDDSALITTEL--------GEPESLQ-- 1084
               ||..::||:  ..:.:..|......|...     |..|.:.|..|        ..|.|||  
Human  1240 ---SELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRH 1301

  Fly  1085 ------HLW--SPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYE 1139
                  :.|  .|..:|.....:.:|..::.||.|:|.|...|     .:.:.|.:|.||..|
Human  1302 SLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYKG-----SVDNQTDSGMVLASE 1359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 128/333 (38%)
FLT4XP_011532780.1 Ig_2 214..301 CDD:464026 24/120 (20%)
IgI_VEGFR 307..406 CDD:409448 17/102 (17%)
Ig strand A 307..311 CDD:409448 1/3 (33%)
Ig strand A' 317..321 CDD:409448 2/6 (33%)
Ig strand B 323..332 CDD:409448 2/9 (22%)
Ig strand C 339..344 CDD:409448 0/4 (0%)
Ig strand C' 347..349 CDD:409448 0/1 (0%)
Ig strand D 353..361 CDD:409448 0/7 (0%)
Ig strand E 366..374 CDD:409448 3/7 (43%)
Ig strand F 384..390 CDD:409448 0/5 (0%)
Ig strand G 395..401 CDD:409448 1/5 (20%)
IgI_VEGFR-3 408..495 CDD:409449 18/102 (18%)
Ig strand A 409..414 CDD:409449 1/4 (25%)
Ig strand A' 419..424 CDD:409449 3/4 (75%)
Ig strand B 426..437 CDD:409449 2/10 (20%)
Ig strand C 441..447 CDD:409449 0/5 (0%)
Ig strand C' 449..452 CDD:409449 0/2 (0%)
Ig strand D 455..457 CDD:409449 0/1 (0%)
Ig strand E 459..464 CDD:409449 2/4 (50%)
Ig strand F 472..480 CDD:409449 2/21 (10%)
Ig strand G 486..495 CDD:409449 1/8 (13%)
Ig_3 636..732 CDD:464046 18/99 (18%)
Ig 755..842 CDD:472250 18/98 (18%)
Ig strand B 772..776 CDD:409353 3/7 (43%)
Ig strand C 785..789 CDD:409353 0/3 (0%)
Ig strand E 808..812 CDD:409353 1/3 (33%)
Ig strand F 822..827 CDD:409353 0/4 (0%)
VEGFR-2_TMD 847..881 CDD:375470 11/54 (20%)
PTKc_VEGFR3 914..1253 CDD:270680 134/342 (39%)

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