Protein Alignment Ret and FGFR1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001167538.1
• Gene: FGFR1 / 2260
• HGNCID: 3688
• Length: 853
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 164/442 - (37%)
• Similarity: 239/442 - (54%)
• Gaps: 66/442 - (14%)

  Fly   699 VITCPLLFVLLLLC---LLIA--------------------QRKMLQRRLGK----QSMTTSSKQ 736
            |:|.||...:::.|   .||:                    ..:|...:|.|    :...|.|..
Human   399 VMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSAD 463

  Fly   737 ALPESGGGDFALMPLQ---SGFRFESG--------DAKWEFPREKLQLDTVLGEGEFGQVLKGFA 790
            :......|...:.|.:   ||....:|        |.:||.||::|.|...||||.||||:   .
Human   464 SSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVV---L 525

  Fly   791 TEIAGL----PG-ITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLL 849
            .|..||    |. :|.|||||||..:...:...|:||.::::.: .|.|:|.||||||......:
Human   526 AEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYV 590

  Fly   850 IIEYARYGSLRSYLRLSRKIECAGVDFA-----DGVEPVNVKMVLTFAWQICKGMAYLSELKLVH 909
            |:|||..|:||.||:..|.   .|:::.     :..|.::.|.:::.|:|:.:||.||:..|.:|
Human   591 IVEYASKGNLREYLQARRP---PGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIH 652

  Fly   910 RDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSF 974
            |||||||||:.:..:.||:||||.||::..|.|.|.:..|:||||||||:|.|.:||.:||||||
Human   653 RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSF 717

  Fly   975 GVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLA 1039
            |||.||:.|||.|||||:..:.|:.|||.|:|||:|.||:..:|.::|.||...|:.||:||.|.
Human   718 GVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLV 782

  Fly  1040 SEFEKL--LGNNAKYIDLETNAVSNPL--YCGD--DSALITTELGEPESLQH 1085
            .:.:::  |.:|.:|:||     |.||  |...  |:...|...||.....|
Human   783 EDLDRIVALTSNQEYLDL-----SMPLDQYSPSFPDTRSSTCSSGEDSVFSH 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	129/291 (44%)
FGFR1	NP_001167538.1	IgI_1_FGFR	58..151	CDD:409362
		Ig strand A	58..61	CDD:409362
		Ig strand A'	73..79	CDD:409362
		Ig strand B	82..92	CDD:409362
		Ig strand C	96..101	CDD:409362
		Ig strand C'	104..106	CDD:409362
		Ig strand D	111..115	CDD:409362
		Ig strand E	118..123	CDD:409362
		Ig strand F	129..138	CDD:409362
		Ig strand G	141..151	CDD:409362
		IgI_2_FGFR	184..278	CDD:409443
		Ig strand A	184..187	CDD:409443
		Ig strand A'	195..200	CDD:409443
		Ig strand B	204..212	CDD:409443
		Ig strand C	218..223	CDD:409443
		Ig strand C'	226..228	CDD:409443
		Ig strand D	237..240	CDD:409443
		Ig strand E	244..249	CDD:409443
		Ig strand F	258..265	CDD:409443
		Ig strand G	268..278	CDD:409443
		Ig	286..390	CDD:472250
		Ig strand B	304..308	CDD:409353
		Ig strand C	317..321	CDD:409353
		Ig strand E	355..359	CDD:409353
		Ig strand F	369..374	CDD:409353
		Ig strand G	382..385	CDD:409353
		PTKc_FGFR1	495..796	CDD:270678	135/306 (44%)