Protein Alignment Ret and old-2

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_496123.1
• Gene: old-2 / 191738
• WormBaseID: WBGene00003863
• Length: 498
• Species: Caenorhabditis elegans
• Alignment Length: 504
• Identity: 142/504 - (28%)
• Similarity: 213/504 - (42%)
• Gaps: 116/504 - (23%)

  Fly   611 PHSSNENKRG-----------IYS-----ASGTCICEDNGKCSCAPLDEEPKMKK-----PRKRK 654
            |.:|.:|:.|           :||     |.|.|         |  |.:..|.||     .|.:.
 Worm    38 PRASEKNELGDSNVQQIIFISLYSVFVALAIGIC---------C--LIKAYKSKKRQLPANRSKG 91

  Fly   655 NETEAEPLLGVRR-----GTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLL 714
            ||...||....::     ...|.:|...|:..|       |.|
 Worm    92 NEYLLEPTTADQKKRYSNNIVPPEPTPYPITSG-------EDD---------------------- 127

  Fly   715 IAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLD--TVL 777
                      .||.....|:::..||     ..|.|:....::....|:.|...|.|.:.  ..|
 Worm   128 ----------FGKTPSRLSNEECPPE-----LKLAPINDRIKYLHYYAEVEINEEDLDISKGRPL 177

  Fly   778 GEGEFGQVLKGF---------ATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHP 832
            |.||||.:.|||         .||     ....||||......|.::...:..|.:::..| .||
 Worm   178 GSGEFGIIRKGFLRSKNSKNKETE-----SRLEVAVKSPLNEYNHIQQELIYDELKVMCAVGKHP 237

  Fly   833 NVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRK-IECAGVDFADGVEPVNVKMVLTFAWQIC 896
            |::.|:|..|..|..::|.|....|.|.|:||.:|: .....:.|......:.:..:::||:||.
 Worm   238 NILALVGGITIGEKRMIISELVENGDLLSFLRKNRRNFTIDQLAFEPEKPSLGLVDLVSFAFQIA 302

  Fly   897 KGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDR-VPVKWMAPESL 960
            |||.||..:..||||||.||||:....:.:|:||||.|.....|.|..:|.|. :|:.||||||:
 Worm   303 KGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRHKNKDYYKTQSVDTPLPIHWMAPESI 367

  Fly   961 ADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQN--------LWSLLKTGYRMDRPENCSEAV 1017
            ...::|.||||||:||..:||.:||.|||..:...:        :.:.|..|.|:.:|.:....:
 Worm   368 DKLLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDSYCKYVLAYLNEGKRLAQPAHADAEI 432

  Fly  1018 YSIVRTCWADEPNGRPSFKFLASEFEKLL--GNNAKYIDL------ETN 1058
            |::::.||..:.|.|.:|......|||.|  .:|..::||      |||
 Worm   433 YNVMKLCWDLDMNSRTTFLDCIEFFEKELKTTSNEYFLDLTRKLRSETN 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/302 (33%)
old-2	NP_496123.1	PTKc	175..458	CDD:270623	96/287 (33%)