Protein Alignment Ret and ver-4

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_509835.2
• Gene: ver-4 / 186632
• WormBaseID: WBGene00006897
• Length: 1216
• Species: Caenorhabditis elegans
• Alignment Length: 1208
• Identity: 261/1208 - (21%)
• Similarity: 436/1208 - (36%)
• Gaps: 343/1208 - (28%)

  Fly   122 HLSLEVTPQPLEEYC----------SELEHICFW----------SSAQYTIAES----------H 156
            |.:|::.|...||:.          :|.:...:|          :.:.|.:::.          |
 Worm    58 HKNLKIEPPKREEHAGFPEIGIRTSAEWKKNEYWFLLKNVRQCDTGSYYCVSDEFKESMLQNTVH 122

  Fly   157 GPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSHFVLKQN-RLYTRQTLDHDELNGLN 220
            ...|:.|.|.|:         ......|...|..:...::.||..:| .||..|...:..|.|.:
 Worm   123 IFVRKLDIFVPL---------KTIYHEHNGSEIIIPCKTTKFVDTKNVELYVNQVKLNSALQGYD 178

  Fly   221 AKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKFD----------FYLEQ 275
            .:.|....:...|:|.:|      :...:.|.  .||:...|....|..|          ||.|:
 Worm   179 QRYGFKLTKNMYTMKPNS------TVFFECKY--TNDSNQDLDYYISNSDPDATLIDQYFFYWEK 235

  Fly   276 ----PYFQADEEAGKKVIYVDKDTLEANAH---LVYAVHNDSHGLF-RPDCHAYEADHTGRPHTI 332
                ||...:......::|:..|:|....|   ::....|...|.: ....|..|...:|.....
 Worm   236 SNDVPYVGNNYSITCHLVYIGSDSLRPLNHQEIVLECPQNQCDGGYNNQSAHEIEKRSSGLRFGD 300

  Fly   333 VSCQ--------LRFSRNGVF-RETPYCV---SLEARDLTIVSRVDAMSATANVC--YHINLSK- 382
            .|.|        ||:.|..|: |:|...|   :|.:.|..|........:..|:.  |.:|.::
 Worm   301 PSSQDIVEKNTMLRYDRLSVYDRKTSRTVNFQNLTSEDSGIYRCTWRNRSKTNIVLDYDLNFNQK 365

  Fly   383 ------LHESEQELPQ-------------ALPLR-----ARQHRIFESEEFNGD----------- 412
                  :..|:|.|..             ..|:.     |:..|::.|....|.
 Worm   366 GTQIKIIETSKQRLKMRKNESTLLFVKFAVFPINKKNYTAKWSRLYNSTVEGGQQVETIRNGFFR 430

  Fly   413 -----SAGR-------SLSPPTVDYDKDVSVYRSAASNFRVVQ------------PDSFLDL--- 450
                 ::||       :|..|.::..   .:|..:.||..:||            |::.|.:
 Worm   431 QITTKTSGRNVFLETLNLKSPKIEMS---GIYVLSISNMDIVQQVKWIIEVENDEPNAQLTIRDP 492

  Fly   451 --MRLRSIRFDIVEDKLGAFGI---TSTSGIV-------------FVKNP-QVLEEAPETIYFLN 496
              :.:.:..|..:...|..|.:   :|.:.::             |.||. :.:::..|..:..|
 Worm   493 LTLNISNQLFLPLNTNLSIFCLAVSSSPTDVIFEYRTDENEWFRGFYKNKLRKIDDTFEKGFIYN 557

  Fly   497 VTWIDQQRLSHVRVINVHLVHGRPENTS----------------CELKVKSRSQTCAQIKYQSQC 545
            ..   ..:.:..:.|||     :.:.||                .|..|.:.....:.|.::...
 Worm   558 FV---LAKRTDFKCINV-----KKKKTSTKFITVTSNANKTFHEIEKSVNATKTEPSDIIFEGDN 614

  Fly   546 VRY-CGLATGGGSCQ--WRGSNSAMF------------------------------GTRYGSCVP 577
            ||. |.:..|.....  |:..|..|.                              ||.|  |:.
 Worm   615 VRLTCVVPYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDRYKRVILNVRNITIDFTGTYY--CIV 677

  Fly   578 ESRYCPDHVCD---PLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCA 639
            :::.. :|..:   .:|:::|               |...|.|.|.|.|||...:.:.|.|.:..
 Worm   678 KNKEF-EHRFETSISVEKVSP---------------PFLLNNNSRSIISASNGQMFDINCKVNGV 726

  Fly   640 PL-------DEEPKMK-----------KPRKRKNETEAEPLLGV-------RRGTPPNQPLQDPM 679
            |.       |..|..|           |..||.|        |:       |.||
 Worm   727 PTPDYTWFKDGYPYTKGKVIGNALHVSKAEKRDN--------GIFWCSATNRAGT---------- 773

  Fly   680 LLGVLNVAGFECDRSCMFFVITCPLLFVLL-----LLCLLIAQRKMLQRRLGKQSMTTSSKQALP 739
            .:..:.|.......|..|::......||::     ||..|..|:.:....|...::..::.:...
 Worm   774 TIDYIEVKVAGASSSSFFWLFITFFAFVVVGIVVSLLWKLFGQKDLKPSELSLNNLKRATDEYQK 838

  Fly   740 ESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGF----ATEIAGLPGIT 800
            .:.......:|::....:.:.:..:|...|.|::...||.|:||.|.||:    :::..|.....
 Worm   839 YTVSEKINNLPVEERIDYLTYNEDYEIDLENLEILETLGSGQFGIVKKGYLNMASSKNFGFESRL 903

  Fly   801 TVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSE--APLLII-EYARYGSLRS 861
            :||:|.....||.........|.:|:..: .||||:.|:||.|.:.  ..|.|: |....|:||.
 Worm   904 SVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLRE 968

  Fly   862 YLRLSRKIEC-----AGVDFADGVEPVNVKM--------------------VLTFAWQICKGMAY 901
            :||..|.:..     .|..|...|.. ||..                    :|:...||..||.:
 Worm   969 FLRERRDVFANELVEKGYIFLTNVRE-NVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDW 1032

  Fly   902 LSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAY--LKRSRDR-VPVKWMAPESLADH 963
            |:.:..||||||.||||::..||.:|:||||.:. :.|.||  ::.|.|. :||:||..||:.|.
 Worm  1033 LANIPCVHRDLACRNVLISKTKIIRIADFGLAKK-HTDKAYYRVRESLDTPLPVRWMPLESITDL 1096

  Fly   964 VYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADE 1028
            .:|.||||||:|:..:|:.|||.:|||.....:|...:|||....||.||.:.||.|::.||...
 Worm  1097 TFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQAS 1161

  Fly  1029 PNGRPSFKFLASEFEKLLGNNAKYI----------DLE 1056
            |:.||:|    :|..||..|:.:|.          |||
 Worm  1162 PDDRPTF----AECIKLFKNHIQYFASKLLQQIEKDLE 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	109/314 (35%)
ver-4	NP_509835.2	IG_like	611..692	CDD:214653	12/83 (14%)
		Ig strand B	615..619	CDD:409353	2/3 (67%)
		Ig strand C	629..633	CDD:409353	0/3 (0%)
		Ig strand E	658..662	CDD:409353	0/3 (0%)
		Ig strand F	672..677	CDD:409353	3/6 (50%)
		Ig	709..782	CDD:472250	18/90 (20%)
		Ig strand B	717..721	CDD:409582	0/3 (0%)
		Ig strand C	730..734	CDD:409582	0/3 (0%)
		Ig strand F	762..767	CDD:409582	0/4 (0%)
		Ig strand G	775..778	CDD:409582	0/2 (0%)
		STYKc	870..1175	CDD:214568	108/310 (35%)