Protein Alignment Ret and trk-1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001360632.1
• Gene: trk-1 / 183575
• WormBaseID: WBGene00017039
• Length: 842
• Species: Caenorhabditis elegans
• Alignment Length: 504
• Identity: 131/504 - (25%)
• Similarity: 226/504 - (44%)
• Gaps: 120/504 - (23%)

  Fly   681 LGVLNVAGFECDRSCMFFVITCP------LLFVLLLLCLLIA----------------QRKMLQR 723
            ||::|  |...|    |.::..|      ::..|:::||||.                :.|:|..
 Worm   360 LGLIN--GTIDD----FIIVEYPYKQEIQIVVFLIVICLLIVVSALAFYHRLKLQSFLREKILSF 418

  Fly   724 R----LGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFP---REKLQLDTVLGEGE 781
            |    |.::..|..:.|...|:      |:.|:......|.......|   ...:::..:||:|.
 Worm   419 RKRISLAQELQTRRASQETEET------LLRLEERSSLASDYTNMTLPFIDMGNIEIHEMLGKGH 477

  Fly   782 FGQVLKGFATEIAG--LPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSS 844
            ||:|.      :|.  ..|..:||||.:::..     ||...|.::||::.|||::||.|...::
 Worm   478 FGEVY------LASWDYTGPRSVAVKSIRRVD-----MATEKEARVLQDLEHPNIVKLYGMTRNN 531

  Fly   845 EAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVH 909
            ...||:.|:..:|.|::||.....::...:.:...:....:|.::.   :|..|:.||.|..:||
 Worm   532 FNLLLVFEHMNHGDLKTYLEQRAPVKSVYLQYPPPLVIDELKWIIK---EITTGLVYLVEQSIVH 593

  Fly   910 RDLAARNVLLA-DGKI------------CKISDFGLTRDVYE-DDAYLKRSRDRVPVKWMAPESL 960
            |||||||.|:| |..:            .||||||::|.:|: .:.|....|..:||:|:.||::
 Worm   594 RDLAARNCLVAGDSDLKATSHFERPPIRVKISDFGMSRRLYDHSEYYTMDHRGALPVRWLPPEAV 658

  Fly   961 ADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCW 1025
            ..|.:|..||:||.||..||.::.|..|:.|::...:.|....|.|..:||.|.:.:|.::..||
 Worm   659 QSHKFTYNSDIWSLGVTMWECMSYGRQPFDGLSNLEVSSFTLAGMRPLKPERCPQDMYDLMVKCW 723

  Fly  1026 ADEPNGRPSFKFLASE--FEKL-------LGNNA------------KYIDL--ETNAVSNPLYCG 1067
            ..||..|.:.|.:..:  |:|:       ..|.|            :|.|:  ||:..::||
 Worm   724 HMEPVKRITAKQILEDELFDKIREGLPYRAANEANSLVSSCMLNINRYKDVVAETSFTTDPL--- 785

  Fly  1068 DDSAL----ITTELGEPESLQHLWSPPKIAYDIHDQA---TSYDQSEEE 1109
            :.|.:    :.||.|:                ::.|.   ..|::||.|
 Worm   786 NSSEIEVNDVPTENGK----------------VNGQTVEKAEYEKSESE 818

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	91/303 (30%)
trk-1	NP_001360632.1	PTKc	471..738	CDD:270623	89/280 (32%)