Protein Alignment Ret and kin-14

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_492004.1
• Gene: kin-14 / 172440
• WormBaseID: WBGene00002198
• Length: 418
• Species: Caenorhabditis elegans
• Alignment Length: 309
• Identity: 101/309 - (32%)
• Similarity: 158/309 - (51%)
• Gaps: 43/309 - (13%)

  Fly   756 RFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALL 820
            ::..|.|.|....|.:.....||||.||:|... ..||.|..  ...|||.::.........|.:
 Worm   119 KYPIGKADWIISHENVIFIKKLGEGAFGEVSLA-ECEIGGRK--VETAVKTMRCQMTRDTRAAFM 180

  Fly   821 SEFQLLQEVSHPNVIKLLGACTSSEAP-----------LLIIEYARYGSLRSYLRLSRKIECAGV 874
            .|.:|:::.|||::::::|.......|           ::::|...:|||.|:||.::
 Worm   181 KEARLMRKYSHPHIVRIIGKIIVKHLPKVGLAVDAHPLMIVMEMCPHGSLLSFLRKNK------- 238

  Fly   875 DFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRD---- 935
                |...::.:  |.|..:...|:|||.:.:.:|||:||||.||:.....|||||||:.|
 Worm   239 ----GKTTLSER--LRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISDFGLSDDKRTE 297

  Fly   936 VYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSL 1000
            :::|      :.|:|||||:|||.:.|.:|:.|||||:||||.||:...||.||||:.  ||.:.
 Worm   298 MHDD------TLDKVPVKWLAPEVMQDKLYSLKSDVWAFGVLMWEIYADGADPYPGMT--NLVTR 354

  Fly  1001 LK---TGYRMDRPENCSEAVYSI-VRTCWADEPNGRPSFKFLASEFEKL 1045
            .|   ..|||..||.....:..| ::.|||..|:.|.:.|.:..:.:.|
 Worm   355 AKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKLKDL 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	97/295 (33%)
kin-14	NP_492004.1	SH2_Fps_family	26..110	CDD:198224
		PTKc	138..401	CDD:270623	96/286 (34%)