Protein Alignment Ret and Kit

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001116205.1
• Gene: Kit / 16590
• MGIID: 96677
• Length: 979
• Species: Mus musculus
• Alignment Length: 945
• Identity: 227/945 - (24%)
• Similarity: 364/945 - (38%)
• Gaps: 294/945 - (31%)

  Fly   289 IYVDKDTLEANAHL----VYAVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETP 349
            ::.||.||:..|.:    |.:|...||.|.:.|
Mouse   196 LHSDKFTLKVRAAIKAIPVVSVPETSHLLKKGD-------------------------------- 228

  Fly   350 YCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGD-S 413
                    ..|:|..:..:|.:.|..:    .|::...|.:.|.      :|..:...:||.: .
Mouse   229 --------TFTVVCTIKDVSTSVNSMW----LKMNPQPQHIAQV------KHNSWHRGDFNYERQ 275

  Fly   414 AGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVF 478
            ...::|...||   |..|:...|:|                         ..|:..:|:|.
Mouse   276 ETLTISSARVD---DSGVFMCYANN-------------------------TFGSANVTTTL---- 308

  Fly   479 VKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINVHLV-----HGRPE-------NTSCELKVKS 531
                :|:|:.     |:|::.:....:......||.||     :.:||       |.:...|.|.
Mouse   309 ----KVVEKG-----FINISPVKNTTVFVTDGENVDLVVEYEAYPKPEHQQWIYMNRTSANKGKD 364

  Fly   532 --RSQTCAQIKYQSQCVRYCGL-ATGGGSCQWRGSNS-AMFGTRYG------------------- 573
              :|...:.|:|.:| :|...| .|.||:..:..||| |.....:.
Mouse   365 YVKSDNKSNIRYVNQ-LRLTRLKGTEGGTYTFLVSNSDASASVTFNVYVNTKPEILTYDRLINGM 428

  Fly   574 -SCVPESRYCPDHVCD-------------PLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSA 624
             .||.|.  .|:...|             |:..::........:|.|::|           :.|:
Mouse   429 LQCVAEG--FPEPTIDWYFCTGAEQRCTTPVSPVDVQVQNVSVSPFGKLV-----------VQSS 480

  Fly   625 SGTCICEDNGKCSCAPLDEEPKMKK------PRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGV 683
            ..:.:...||...|...::..|...      ....|.:.:|..|.             .|:|:|.
Mouse   481 IDSSVFRHNGTVECKASNDVGKSSAFFNFAFKGNNKEQIQAHTLF-------------TPLLIGF 532

  Fly   684 LNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFAL 748
            :..||                   .:.:.:::...|.||:     .|.....:.:.|..|.::..
Mouse   533 VVAAG-------------------AMGIIVMVLTYKYLQK-----PMYEVQWKVVEEINGNNYVY 573

  Fly   749 M-PLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSN 812
            : |.|..:     |.||||||.:|.....||.|.||:|::..|..:.......||||||||..::
Mouse   574 IDPTQLPY-----DHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAH 633

  Fly   813 SVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSR--------- 867
            ..|..||:||.::|..: :|.|::.||||||.....|:|.||..||.|.::||..|
Mouse   634 LTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQE 698

  Fly   868 -KIECA------------------------GVDFA---------------------------DGV 880
             :.|.|                        ||.:.                           |..
Mouse   699 EQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDE 763

  Fly   881 EPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKR 945
            ..:::..:|:|::|:.||||:|:....:||||||||:||..|:|.||.||||.||:..|..|:.:
Mouse   764 LALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVK 828

  Fly   946 SRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMDR 1009
            ...|:|||||||||:...|||.:|||||:|:..|||.:||:|||||: .....:.::|.|:||..
Mouse   829 GNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVS 893

  Fly  1010 PENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCG------- 1067
            ||:....:|.:::|||..:|..||:||.:....||.:.::.|:|      .||...|.
Mouse   894 PEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHI------YSNLANCNPNPENPV 952

  Fly  1068 --DDSALITTELGEPESLQHLWSPPKIAYDIHDQA 1100
              |.|..:.:......|.|.|.        :|:.|
Mouse   953 VVDHSVRVNSVGSSASSTQPLL--------VHEDA 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	121/341 (35%)
Kit	NP_001116205.1	ig	217..308	CDD:395002	24/168 (14%)
		Ig strand B	230..234	CDD:409353	1/3 (33%)
		Ig strand C	244..248	CDD:409353	1/7 (14%)
		Ig strand E	276..280	CDD:409353	0/3 (0%)
		Ig strand G	300..306	CDD:409353	1/5 (20%)
		IgI_4_SCFR	314..414	CDD:409446	24/105 (23%)
		Ig strand A	314..320	CDD:409446	2/10 (20%)
		Ig strand A'	324..329	CDD:409446	0/4 (0%)
		Ig strand B	332..342	CDD:409446	4/9 (44%)
		Ig strand C	346..353	CDD:409446	2/6 (33%)
		Ig strand C'	355..358	CDD:409446	1/2 (50%)
		Ig strand D	361..366	CDD:409446	2/4 (50%)
		Ig strand E	375..384	CDD:409446	3/9 (33%)
		Ig strand F	391..399	CDD:409446	1/7 (14%)
		Ig strand G	402..413	CDD:409446	1/10 (10%)
		Ig	429..505	CDD:409353	14/88 (16%)
		Ig strand C	440..444	CDD:409353	1/3 (33%)
		Ig strand E	473..481	CDD:409353	3/18 (17%)
		Ig strand F	491..496	CDD:409353	1/4 (25%)
		PTKc_Kit	556..930	CDD:270682	132/378 (35%)
		Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250	571..573		0/1 (0%)