Protein Alignment Atf3 and FOSB

DIOPT Version :10

• Sequence 1: NP_001259125.1
• Gene: Atf3 / 43867
• FlyBaseID: FBgn0028550
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_006723.2
• Gene: FOSB / 2354
• HGNCID: 3797
• Length: 338
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 89/376 - (23%)
• Similarity: 149/376 - (39%)
• Gaps: 83/376 - (22%)

  Fly    63 SASCSAASTPVVTVRHFNGHPNGQSHSQDSSHSSCSGSPLDSPAGTATTPSVQQTCSRLIKEGLK 127
            |:|.||.|..:.:|..|...|...:..:.:......||.:  |..||.|.|  |....|::..|
Human    16 SSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFV--PTVTAITTS--QDLQWLVQPTL- 75

  Fly   128 LSIQSKRKLSTCDSSSGS------------EQPHSKYSRRSSNHNGHSGSSNNYSGSMSNANDLD 180
                    :|:...|.|.            :.|.:.||  :...:|:|....:.||..|.:....
Human    76 --------ISSMAQSQGQPLASQPPVVDPYDMPGTSYS--TPGMSGYSSGGASGSGGPSTSGTTS 130

  Fly   181 DDCEESSDDDSETKSQPKGLTPEDEDRRRRRRERNKIAATKCRMKKRERTQNLIKESEVLDTQNV 245
            .............:.:.:.||||:|::||.||||||:||.|||.::||.|..|..|::.|:.:..
Human   131 GPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKA 195

  Fly   246 ELKNQVRQLETERQKLVDMLKSHGCQRAGGCQLPSQLLQSPAQKYLSELELETVSIDGPNSGNNN 310
            ||::::.:|:.|:::|..:|.:|    ..||::|.:                    :||..|...
Human   196 ELESEIAELQKEKERLEFVLVAH----KPGCKIPYE--------------------EGPGPGPLA 236

  Fly   311 QRLQSIPSMATFKYGSKTAAAMAQQLPNGYCKPSPSAQEFEHAGYQQQQQQQQQQQPQSLNP--- 372
            : ::.:|..|..|     ....:..||    .|.|....|          |..|..|.:|..
Human   237 E-VRDLPGSAPAK-----EDGFSWLLP----PPPPPPLPF----------QTSQDAPPNLTASLF 281

  Fly   373 --AGNNVIDQQHANPSPSLLSDYVPNCDGLTG-------SASNHPSHNNNN 414
              :...|:.......:||..|.:|..|..::.       |.|:.||...|:
Human   282 THSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNS 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atf3	NP_001259125.1	bZIP_ATF3	215..268	CDD:269870	19/52 (37%)
		coiled coil	215..265	CDD:269870	18/49 (37%)
FOSB	NP_006723.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	79..191		33/113 (29%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	157..182		16/24 (67%)
		bZIP_Fos	165..218	CDD:269869	19/52 (37%)
		coiled coil	165..217	CDD:269869	19/51 (37%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	183..211		7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	222..276		16/93 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..338		5/17 (29%)