Protein Alignment Atf3 and FOS

DIOPT Version :10

• Sequence 1: NP_001259125.1
• Gene: Atf3 / 43867
• FlyBaseID: FBgn0028550
• Length: 688
• Species: Drosophila melanogaster
• Sequence 2: NP_005243.1
• Gene: FOS / 2353
• HGNCID: 3796
• Length: 380
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 110/495 - (22%)
• Similarity: 184/495 - (37%)
• Gaps: 172/495 - (34%)

  Fly    61 SSSASCSAASTPVVTVRHFNGHPNGQS----HSQDSSHSSCSGSPLDS---------------PA 106
            :||:.||:||            |.|.|    ||...|.|| .|||:::               |.
Human    12 ASSSRCSSAS------------PAGDSLSYYHSPADSFSS-MGSPVNAQDFCTDLAVSSANFIPT 63

  Fly   107 GTA--TTPSVQQTCSRLIKEGLKLSIQSKRKLSTCDSSSGSEQPH---------SKYSRRSSNHN 160
            .||  |:|.:|.    |::..|..|:          :.|.:..||         ..|||
Human    64 VTAISTSPDLQW----LVQPALVSSV----------APSQTRAPHPFGVPAPSAGAYSR------ 108

  Fly   161 GHSGSSNNYSGSMSNANDLDDDCEESSDDDSETKSQPKGLTPEDEDRRRRRRERNKIAATKCRMK 225
              :|.....:|..:.:.......|:              |:||:|::||.||||||:||.|||.:
Human   109 --AGVVKTMTGGRAQSIGRRGKVEQ--------------LSPEEEEKRRIRRERNKMAAAKCRNR 157

  Fly   226 KRERTQNLIKESEVLDTQNVELKNQVRQLETERQKLVDMLKSHGCQRAGGCQLPSQLLQSPAQKY 290
            :||.|..|..|::.|:.:...|:.::..|..|::||..:|.:|    ...|::|..|      .:
Human   158 RRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAH----RPACKIPDDL------GF 212

  Fly   291 LSELELETVSIDGPNSGNNNQRLQSIPSMATFKYGSKTAAAMAQQLPNGYCKPSPSAQEFEHAGY 355
            ..|:.:.::.:.|           .:|.:||    .::..|....|.|. .:|.||.:..:..
Human   213 PEEMSVASLDLTG-----------GLPEVAT----PESEEAFTLPLLND-PEPKPSVEPVKSI-- 259

  Fly   356 QQQQQQQQQQQP--QSLNPAGNNVIDQQHANPSPSLLSDYVPNCDGLTGS---ASNHPSHNNNNN 415
               ...:.:.:|  ..|.||.        :.||.|..:..||:.| |:||   |...|.|
Human   260 ---SSMELKTEPFDDFLFPAS--------SRPSGSETARSVPDMD-LSGSFYAADWEPLH----- 307

  Fly   416 NNNSSGASSNTSNNNSNISSHSSNATSSTTPTATSSAIEFVKNELVDSQSPYTTALSAERFLFEP 480
                        :.:..:...::......||..|.:          .|.:.||::..   |.:..
Human   308 ------------SGSLGMGPMATELEPLCTPVVTCT----------PSCTAYTSSFV---FTYPE 347

  Fly   481 SDGFPDIKHACVLPSPCGINGLNMASVVNTNGSTGNNNNS 520
            :|.||    :|              :..:..||:.|..:|
Human   348 ADSFP----SC--------------AAAHRKGSSSNEPSS 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atf3	NP_001259125.1	bZIP_ATF3	215..268	CDD:269870	19/52 (37%)
		coiled coil	215..265	CDD:269870	18/49 (37%)
FOS	NP_005243.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..138		4/32 (13%)
		Basic motif, required for the activation of phospholipid synthesis, but not for CDS1-binding	139..159		13/19 (68%)
		bZIP_Fos	147..200	CDD:269869	19/52 (37%)
		coiled coil	147..199	CDD:269869	19/51 (37%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	165..193		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..380		5/30 (17%)