Protein Alignment HnRNP-K and PCBP3

DIOPT Version :10

• Sequence 1: NP_995906.1
• Gene: HnRNP-K / 43862
• FlyBaseID: FBgn0267791
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001335169.1
• Gene: PCBP3 / 54039
• HGNCID: 8651
• Length: 394
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 112/510 - (21%)
• Similarity: 173/510 - (33%)
• Gaps: 191/510 - (37%)

  Fly    18 PQDQKRNRRNEE----------TVRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQGPER 72
            ||.|...|...:          |:|:|:.....|::|||.|:.::|||.:..|.:::.:...|||
Human    25 PQPQFGRRMESKVSEGGLNVTLTIRLLMHGKEVGSIIGKKGETVKKMREESGARINISEGNCPER 89

  Fly    73 TIQISADIESTLEIITEMLKYFEE------------RDEDFDVRLLIHQSLAGCVIGKGGQKIKE 125
            .:.|:...::..:....:...|||            ......:||::..|..|.:|||||.||||
Human    90 IVTITGPTDAIFKAFAMIAYKFEEDIINSMSNSPATSKPPVTLRLVVPASQCGSLIGKGGSKIKE 154

  Fly   126 IRDRIGCRFLKVFSNVAPQSTDRVVQTVGKQSQVIEAVREVITLTRDTPIKGAIHNYDPMNFDRV 190
            ||:..|.: ::|..::.|.||:|.|...|....:|:.|:::..:..::|.|||...|.|
Human   155 IRESTGAQ-VQVAGDMLPNSTERAVTISGTPDAIIQCVKQICVVMLESPPKGATIPYRP------ 212

  Fly   191 YADEYGGYGTGSGSTRPSQRGNNRNGGGAGGVAGGAAGGNGGGFNAGGARGNAGGRGGADRFGGA 255
                           :|
Human   213 ---------------KP------------------------------------------------ 214

  Fly   256 AGGAVAGAGMGQRDNPFINPWANGGGGDVDGFGNNAGGAGGFAGNSFGGGAGGPFGGGSFGNNGF 320
            |...|..||...|.:|
Human   215 ASTPVIFAGGQVRADP------------------------------------------------- 230

  Fly   321 GGGPSDFGGNSGNFG-----------QAQGTNSLP---SLGSFSQNQGGTSSLPSLGSFGQNPGG 371
                  ...::.|..           ..||..::|   .|....|.....:..|.||.  .||..
Human   231 ------LAASTANLSLLLQHPPLPAYTIQGQYAIPHPDQLTKLHQLAMQQTPFPPLGQ--TNPAF 287

  Fly   372 PG-GLGNGLSGGANGGVGTLGGANGAGGFNAVGGANGGPNGSPNAATNVPQGHDPNNSTQVTIPK 435
            || .|....|..|..                :.|.:.|.:.||.|:|:           ::|||.
Human   288 PGEKLPLHSSEEAQN----------------LMGQSSGLDASPPASTH-----------ELTIPN 325

  Fly   436 ELAGAIIGKGGGRIRRIRNESSAYITIDEPLPNSNDRIITISGTPKQIQMAQYLL 490
            :|.|.|||:.|.:|..||..|.|.|.|......|::|.|||:|||..|.:||||:
Human   326 DLIGCIIGRQGTKINEIRQMSGAQIKIANATEGSSERQITITGTPANISLAQYLI 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HnRNP-K	NP_995906.1	KH-I_HNRNPK_rpt1	28..91	CDD:411860	16/72 (22%)
		KH-I_HNRNPK_rpt2	100..170	CDD:411861	25/69 (36%)
		KH-I_HNRNPK_rpt3	426..498	CDD:411862	29/65 (45%)
PCBP3	NP_001335169.1	KH-I_PCBP3_rpt1	38..114	CDD:411944	18/75 (24%)
		KH-I_PCBP3_rpt2	125..203	CDD:411947	25/78 (32%)
		KH-I_PCBP3_rpt3	309..383	CDD:411950	34/83 (41%)