Protein Alignment HnRNP-K and PCBP2

DIOPT Version :10

• Sequence 1: NP_995906.1
• Gene: HnRNP-K / 43862
• FlyBaseID: FBgn0267791
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_005007.2
• Gene: PCBP2 / 5094
• HGNCID: 8648
• Length: 366
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 107/492 - (21%)
• Similarity: 168/492 - (34%)
• Gaps: 185/492 - (37%)

  Fly    30 TVRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQGPERTIQISADIESTLEIITEMLKYF 94
            |:|:|:.....|::|||.|:.::|||.:..|.:::.:...|||.|.::.   .|..|........
Human    15 TIRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIITLAG---PTNAIFKAFAMII 76

  Fly    95 EERDEDFD---------------VRLLIHQSLAGCVIGKGGQKIKEIRDRIGCRFLKVFSNVAPQ 144
            ::.:||..               :||::..|..|.:|||||.||||||:..|.: ::|..::.|.
Human    77 DKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKIKEIRESTGAQ-VQVAGDMLPN 140

  Fly   145 STDRVVQTVGKQSQVIEAVREVITLTRDT----PIKGAIHNY--DPMNFDRVYADEYGGYGTGSG 203
            ||:|.:...|....:||.|:::..:..:|    |.||....|  .|.:...::|.....|.|||.
Human   141 STERAITIAGIPQSIIECVKQICVVMLETLSQSPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSD 205

  Fly   204 S-----TRPSQRGNNRNGGGAGGVAGGAAGGNGGGFNAGGARGNAGGRGGADRFGGAAGGAVAGA 263
            |     |.||.
Human   206 SASFPHTTPSM------------------------------------------------------ 216

  Fly   264 GMGQRDNPFINPWANGGGGDVDGFGNNAGGAGGFAGNSFGGGAGGPFGGGSFGNNGFGGGPSDFG 328
                    .:||       |::                                    |.|.:..
Human   217 --------CLNP-------DLE------------------------------------GPPLEAY 230

  Fly   329 GNSGNFGQAQGTNSLPSLGSFSQNQGGTSSLPSLGSFGQNPGGPGGLGNGLSGGANGGVGTLGGA 393
            ...|.:...|     |.|....|.....|..|.                               .
Human   231 TIQGQYAIPQ-----PDLTKLHQLAMQQSHFPM-------------------------------T 259

  Fly   394 NGAGGFNAVGGANGGPNG-----SPNAATNVPQGHDPNNSTQVTIPKELAGAIIGKGGGRIRRIR 453
            :|..||:.:..::....|     ..:|.|         .|.::|||.:|.|.|||:.|.:|..||
Human   260 HGNTGFSGIESSSPEVKGYWAGLDASAQT---------TSHELTIPNDLIGCIIGRQGAKINEIR 315

  Fly   454 NESSAYITIDEPLPNSNDRIITISGTPKQIQMAQYLL 490
            ..|.|.|.|..|:..|.||.:||:|:...|.:||||:
Human   316 QMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLI 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HnRNP-K	NP_995906.1	KH-I_HNRNPK_rpt1	28..91	CDD:411860	18/60 (30%)
		KH-I_HNRNPK_rpt2	100..170	CDD:411861	26/84 (31%)
		KH-I_HNRNPK_rpt3	426..498	CDD:411862	29/65 (45%)
PCBP2	NP_005007.2	KH-I_PCBP1_2_rpt1	13..82	CDD:411943	18/69 (26%)
		KH-I_PCBP1_2_rpt2	92..169	CDD:411946	25/77 (32%)
		KH-I_PCBP1_2_rpt3	285..360	CDD:411949	31/77 (40%)