Protein Alignment HnRNP-K and PCBP1

DIOPT Version :10

• Sequence 1: NP_995906.1
• Gene: HnRNP-K / 43862
• FlyBaseID: FBgn0267791
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_006187.2
• Gene: PCBP1 / 5093
• HGNCID: 8647
• Length: 356
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 101/482 - (20%)
• Similarity: 162/482 - (33%)
• Gaps: 174/482 - (36%)

  Fly    30 TVRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQGPERTIQISADIESTLEIITEMLKYF 94
            |:|:|:.....|::|||.|:.::::|.:..|.:::.:...|||.|.::.   .|..|........
Human    15 TIRLLMHGKEVGSIIGKKGESVKRIREESGARINISEGNCPERIITLTG---PTNAIFKAFAMII 76

  Fly    95 EERDEDFD---------------VRLLIHQSLAGCVIGKGGQKIKEIRDRIGCRFLKVFSNVAPQ 144
            ::.:||.:               :||::..:..|.:|||||.||||||:..|.: ::|..::.|.
Human    77 DKLEEDINSSMTNSTAASRPPVTLRLVVPATQCGSLIGKGGCKIKEIRESTGAQ-VQVAGDMLPN 140

  Fly   145 STDRVVQTVGKQSQVIEAVREVITLTRDT----PIKGAIHN--YDPMNFDRVYADEYGGYGTGSG 203
            ||:|.:...|....|.|.|:::..:..:|    | :|.:..  |.||
Human   141 STERAITIAGVPQSVTECVKQICLVMLETLSQSP-QGRVMTIPYQPM------------------ 186

  Fly   204 STRPSQRGNNRNGGGAGGVAGGAAGGNGGGFNAGGARGNAGGRGGADRFGGAAGGAVAGAGMGQR 268
                                              .|.......||.||...|||
Human   187 ----------------------------------PASSPVICAGGQDRCSDAAG----------- 206

  Fly   269 DNPFINPWANGGGGDVDGFGNNAGGAGGFAGNSFGGGAGGPFGGGSFGNNGFGGGPSDFGGNSGN 333
                 .|.|.   .|::|
Human   207 -----YPHAT---HDLEG----------------------------------------------- 216

  Fly   334 FGQAQGTNSLPSLGSFSQNQGGTSSLPSLGSFGQNPGGPGGLGNGLSGGANGGVGTLGGANGAGG 398
                      |.|.::|.....|.|...|....|            ..........:.|..|..|
Human   217 ----------PPLDAYSIQGQHTISPLDLAKLNQ------------VARQQSHFAMMHGGTGFAG 259

  Fly   399 FNAVGGANGGPNGSPNAATNVPQGHDPNNSTQVTIPKELAGAIIGKGGGRIRRIRNESSAYITID 463
            .::......|...|.:|:|        ..:.::|||..|.|.|||:.|..|..||..|.|.|.|.
Human   260 IDSSSPEVKGYWASLDAST--------QTTHELTIPNNLIGCIIGRQGANINEIRQMSGAQIKIA 316

  Fly   464 EPLPNSNDRIITISGTPKQIQMAQYLL 490
            .|:..|:.|.:||:|:...|.:||||:
Human   317 NPVEGSSGRQVTITGSAASISLAQYLI 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HnRNP-K	NP_995906.1	KH-I_HNRNPK_rpt1	28..91	CDD:411860	16/60 (27%)
		KH-I_HNRNPK_rpt2	100..170	CDD:411861	25/84 (30%)
		KH-I_HNRNPK_rpt3	426..498	CDD:411862	27/65 (42%)
PCBP1	NP_006187.2	KH-I_PCBP1_2_rpt1	13..82	CDD:411943	16/69 (23%)
		KH-I_PCBP1_2_rpt2	92..169	CDD:411946	24/77 (31%)
		KH-I_PCBP1_2_rpt3	276..351	CDD:411949	29/76 (38%)