Protein Alignment HnRNP-K and Nova2

DIOPT Version :10

• Sequence 1: NP_995906.1
• Gene: HnRNP-K / 43862
• FlyBaseID: FBgn0267791
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001025048.2
• Gene: Nova2 / 384569
• MGIID: 104296
• Length: 492
• Species: Mus musculus
• Alignment Length: 559
• Identity: 141/559 - (25%)
• Similarity: 212/559 - (37%)
• Gaps: 148/559 - (26%)

  Fly    14 EGEGPQDQKR-----------NRRN-----EETVRILIPSSIAGAVIGKGGQHIQKMRTQYKATV 62
            |.|.|..:||           .|.|     |..:::||||..||::||||||.|.:::.:..||:
Mouse     2 EPEAPDSRKRPLETPPEVVCTKRSNTGEEGEYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATI 66

  Fly    63 SVDDSQG--PERTIQISADIESTLEIITEMLKYFEER-------------------------DED 100
            .:..|:.  |..|.::.. ::.|.|.:..:..:..|:                         |..
Mouse    67 KLSKSKDFYPGTTERVCL-VQGTAEALNAVHSFIAEKVREIPQAMTKPEVVNILQPQTTMNPDRA 130

  Fly   101 FDVRLLIHQSLAGCVIGKGGQKIKEIRDRIGCRFLKVFSNVAPQS---TDRVVQTVGKQSQVIEA 162
            ...:|::..|.||.:|||||..:|.:.::.|.   .|..:..|:.   .:|||...|:..||.:|
Mouse   131 KQAKLIVPNSTAGLIIGKGGATVKAVMEQSGA---WVQLSQKPEGINLQERVVTVSGEPEQVHKA 192

  Fly   163 VREVITLTRDTP------------IKGAIHNYDPMNFDRVYADEYGGYGTGSGSTRPSQRGNNRN 215
            |..::...::.|            :.|.:.|.:|               |||....|:.
Mouse   193 VSAIVQKVQEDPQSSSCLNISYANVAGPVANSNP---------------TGSPYASPAD------ 236

  Fly   216 GGGAGGVAGGAAGGNGGGFNAGGARGNAGGRGGADRFGGAAGGAVAGAGMGQRDNPFINPWANGG 280
                  |...||..:...  |.|..|.||               :||.|......|..:
Mouse   237 ------VLPAAAAASAAA--ASGLLGPAG---------------LAGVGAFPAALPAFS------ 272

  Fly   281 GGDVDGFGN--NAGGAGGFAGNSFGGGAGGPFGGGSFGNNGFGGGPSDFGGNSGNFGQAQGTNSL 343
            |.|:.....  |...:.|:..||...|.......|.......|..|:          .|...|.|
Mouse   273 GTDLLAISTALNTLASYGYNTNSLSLGLNSAAASGVLAAVAAGANPA----------AAAAANLL 327

  Fly   344 PSLGSFSQNQGGTSSLPSLGSFGQNPGGPGGLGN-GLSGGANGGVGT-LGGANGAGG------FN 400
            .|..      |...:.|..|:....|..||.||: .|:..|||.:|. .|||.||||      ..
Mouse   328 ASYA------GDAGAGPGAGAAPPPPPPPGALGSFALAAAANGYLGAGAGGAAGAGGAPLVAAAA 386

  Fly   401 AVGGANGGPNGSPNAATNVPQGHDPNNSTQVTIPKELAGAIIGKGGGRIRRIRNESSAYITID-- 463
            |.|.|.|.......||.:..:      ..::.:|:.|.|||:||||..:...:..:.|.|.|.
Mouse   387 AAGAAGGFLTAEKLAAESAKE------LVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKK 445

  Fly   464 -EPLPNSNDRIITISGTPKQIQMAQYLLQQSV-HENGRR 500
             |.||.:.:|.:||:|:|...|.||||:.|.| :|.|.|
Mouse   446 GEFLPGTRNRRVTITGSPAATQAAQYLISQRVTYEQGVR 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HnRNP-K	NP_995906.1	KH-I_HNRNPK_rpt1	28..91	CDD:411860	21/64 (33%)
		KH-I_HNRNPK_rpt2	100..170	CDD:411861	21/72 (29%)
		KH-I_HNRNPK_rpt3	426..498	CDD:411862	28/75 (37%)
Nova2	NP_001025048.2	Bipartite nuclear localization signal. /evidence=ECO:0000255	10..26		3/15 (20%)
		KH-I_NOVA_rpt1	33..104	CDD:411863	21/71 (30%)
		KH-I_NOVA_rpt2	131..200	CDD:411864	21/71 (30%)
		KH-I_NOVA_rpt3	409..477	CDD:411807	26/67 (39%)