Protein Alignment HnRNP-K and Nova1

DIOPT Version :10

• Sequence 1: NP_995906.1
• Gene: HnRNP-K / 43862
• FlyBaseID: FBgn0267791
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001401845.1
• Gene: Nova1 / 298992
• RGDID: 621345
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 570
• Identity: 128/570 - (22%)
• Similarity: 203/570 - (35%)
• Gaps: 186/570 - (32%)

  Fly    16 EGPQD---QKRNRRNEE---TVRILIPSSIAGAVIGKGGQHIQKMRTQYKATVSVDDSQG--PER 72
            |.|.:   .||....|:   .:::||||..||::||||||.|.:::.:..||:.:..|:.  |..
  Rat    31 EAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGT 95

  Fly    73 TIQISADIESTLEIITEMLKYFEERDEDF------------------------------------ 101
            |.::.. |:.|:|.:..:..:..|:..:.
  Rat    96 TERVCL-IQGTIEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQTLPSSPTTTK 159

  Fly   102 -------------DVRLLIHQSLAGCVIGKGGQKIKEIRDRIGCRFLKVFSNVAPQS---TDRVV 150
                         .|::::..|.||.:|||||..:|.|.::.|.   .|..:..|..   .:|||
  Rat   160 SSPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAIMEQSGA---WVQLSQKPDGINLQERVV 221

  Fly   151 QTVGKQSQVIEAVREVITLTRDTPIKGAIHNYDPMNFDRVYADEYGGYGTGSGSTRPSQRGNNRN 215
            ...|:..|..:||..:|...::.|..|:..|..       ||:
  Rat   222 TVSGEPEQNRKAVELIIQKIQEDPQSGSCLNIS-------YAN---------------------- 257

  Fly   216 GGGAGGVAGGAAGGNGGGFNAGGARGNAGGRGGADRFGGAAGGAVAGAGMGQRDNPFIN-----P 275
                  |.|..|..|..|                                    :|:.|     |
  Rat   258 ------VTGPVANSNPTG------------------------------------SPYANTAEVLP 280

  Fly   276 WANGGGGDVDGFGNNAGGA------GGFAGNSFGGGAGGPFGGGSFGNN----GFGGGPSDFGGN 330
            .|....| :.|..|.||.|      .||.||.............|:|.|    |.|
  Rat   281 TAAAAAG-LLGHANLAGVAAFPAVLSGFTGNDLVAITSALNTLASYGYNLNTLGLG--------- 335

  Fly   331 SGNFGQAQGTNSLPSLGSFSQNQGGTSSLPSLGSFGQNPGGPGGLGNGLSGGANGGVGTLGGANG 395
               ..||..|.:|.:..:.:......::|  |.::.......|....|.:|  ...:|:|..|..
  Rat   336 ---LSQAAATGALAAAAASANPAAAAANL--LATYASEASASGSTAGGTAG--TFALGSLAAATA 393

  Fly   396 A--GGFNAVGGANGGPNGSPNAATNV---PQGHDPNNS-TQVTIPKELAGAIIGKGGGRIRRIRN 454
            |  |.|.|         .||.||:.:   .:..|.:.. .::.:|:.|.|||:||||..:...:.
  Rat   394 ATNGYFGA---------ASPLAASAILGTEKSTDGSKDVVEIAVPENLVGAILGKGGKTLVEYQE 449

  Fly   455 ESSAYITID---EPLPNSNDRIITISGTPKQIQMAQYLLQQSV-HENGRR 500
            .:.|.|.|.   |.:|.:.:|.:||:|||...|.||||:.|.: :|.|.|
  Rat   450 LTGARIQISKKGEFVPGTRNRKVTITGTPAATQAAQYLITQRITYEQGVR 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HnRNP-K	NP_995906.1	KH-I_HNRNPK_rpt1	28..91	CDD:411860	22/67 (33%)
		KH-I_HNRNPK_rpt2	100..170	CDD:411861	22/121 (18%)
		KH-I_HNRNPK_rpt3	426..498	CDD:411862	27/76 (36%)
Nova1	NP_001401845.1	KH-I_NOVA_rpt1	49..121	CDD:411863	22/72 (31%)
		KH-I_NOVA_rpt2	172..241	CDD:411864	22/71 (31%)
		KH-I_NOVA_rpt3	422..492	CDD:411807	26/69 (38%)