DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fuss and Snoo

DIOPT Version :9

Sequence 1:	NP_001162829.1	Gene:	fuss / 43835	FlyBaseID:	FBgn0039932	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001097115.1	Gene:	Snoo / 5740414	FlyBaseID:	FBgn0085450	Length:	1223	Species:	Drosophila melanogaster

Alignment Length:	739	Identity:	155/739 - (20%)
Similarity:	255/739 - (34%)	Gaps:	220/739 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LYGVQIVSLHIEGQERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPV 101
            |.|..|....:.|:.||||.|..|.:|..||..:|:.....|||.|.|||..||...:.|..:|.
  Fly   121 LEGKTIGCFSVGGEMRLCLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPS 185

  Fly   102 SSRRCGMITRREAERLCKSFL-GDNTPPRLPDD------FAFNVQHKCAWGCRGSFLPSRYNSSR 159
            ..:..|:|||.:|||||.:.| ..:....:|.:      .:|:|.|||...|.|...|..|:..:
  Fly   186 DVKASGLITRTDAERLCAALLHRSDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQK 250

  Fly   160 AKCIKCSYCGMFFSPNKFIFHSHRITTNDR-YVQPDAANFNSWRRHMSLSGNDYDE--------K 215
            ..||||..|..:|||.||:.|.||...|.. :...|:.|::.: .|::|...:.::        |
  Fly   251 PTCIKCLECDGWFSPQKFVGHVHRKFENHTCHWGFDSRNWHDY-LHVALDVENREKYQIILDQLK 314

  Fly   216 IIHAWEDVKAMFNGGTRKR-------------------------LVGSSINPRSPGSPTQSTAVS 255
            .:...|..||......:||                         |||:...|..|........:.
  Fly   315 EVELKEMHKAQRELEHKKRKAEMLMDDGMLGSGPVLGLAGHPHGLVGALAPPPPPPMKQPQMDIP 379

  Fly   256 SG-------VGSSSCGSPTSF------------ERDTNEVDGKSGSSLPQRSQIDSQYNYGTVAA 301
            ||       .|::...|...:            ||:      :....||....:..|:.
  Fly   380 SGKKQLQQLKGATVAASALEYQYQVMYAHCVQKERE------REREHLPHSHPLPRQHR------ 432

  Fly   302 AAAVVGVTAVAAATVGVP----------------------------FNLHGSTV----------- 327
                    ||..||...|                            .:.:|:|:
  Fly   433 --------AVLVATTPYPHLPQYPTPPTLNSSSAFRPWGPDTTKAFLHAYGATLSSLPYACQEPP 489

  Fly   328 --------------------------LSPLHS-LRNERDLSIMPISRNFVVDYMWQQKDQHYQQP 365
                                      |:|..| |..|||.....:.|..:.....::|:..:|..
  Fly   490 ELQNPERVVRSTDKRYAERTYQPNVALAPRKSILSKERDKDRERMEREVMERQRLREKETDHQVV 554

  Fly   366 YARK-------IPSGDNSDS---SLDFDSWVKP------DSNNPIP------------------- 395
            :.::       .|:....|.   .||.   |:|      .||:|:|
  Fly   555 HIKQERSQTPTPPTASPPDGVVLPLDV---VEPPHPSSSGSNSPLPAHLPAAPATAPPNAGGAPP 616

  Fly   396 ---NANSVRTSDNCSFNIKNE--SHSSIYGIIKNHKLSGVPNSGLNLSDYNIPSILNCSAFKPVV 455
               |..::|:.:..|....||  |.:|.:....:|.....|.:|......:|.:.:|..| |.:.
  Fly   617 TPTNLRNMRSPEEFSAGGSNEITSSTSPHHQQSSHHQVVQPTAGAPPPSQHIIATVNQHA-KLLP 680

  Fly   456 ASTAIV----STSLYTRSNESTRTDCNNPAQSTRTTTVLTHNSISASSHQIVGHKTFSPILGKIH 516
            :|:::.    |:||...:||.:|...|....|.:  .|:..:.::...||  .|.|.   :....
  Fly   681 SSSSLPNGNGSSSLAATNNEPSRIRINKNLMSQQ--PVVAVSGMTPHHHQ--HHPTH---MHHFS 738

  Fly   517 SNPEKNRIVSVFASSSTGNADDNDDDDEVVDIETTEDEGKFTVQHADSPKTQYDAISGSDSPSRS 581
            ....|::..|...|||.|           :::.|.......:..||..|||.:.::...:...::
  Fly   739 HGYYKSQASSPTQSSSAG-----------LNLSTHSSNVVSSPHHATQPKTHHSSVGSGNHGLQN 792

  Fly   582 PSTSTNIDVEQDVDVDIITTDTED 605
            .......:.|       ::|||:|
  Fly   793 GKPHLGSEFE-------LSTDTDD 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fuss	NP_001162829.1	Ski_Sno	25..123	CDD:280577	35/86 (41%)
fuss	NP_001162829.1	c-SKI_SMAD_bind	135..228	CDD:198114	31/101 (31%)
Snoo	NP_001097115.1	Ski_Sno	114..207	CDD:280577	34/85 (40%)
Snoo	NP_001097115.1	c-SKI_SMAD_bind	226..317	CDD:198114	28/91 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010