DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fuss and skor1

DIOPT Version :9

Sequence 1:	NP_001162829.1	Gene:	fuss / 43835	FlyBaseID:	FBgn0039932	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_012814921.1	Gene:	skor1 / 100491438	XenbaseID:	XB-GENE-877133	Length:	742	Species:	Xenopus tropicalis

Alignment Length:	781	Identity:	268/781 - (34%)
Similarity:	369/781 - (47%)	Gaps:	176/781 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SVAHFDRMENCQT---SQRSNHVSSVLLYGVQIVSLHIEGQERLCLAQISNTLLKQFSYNEIHNR 74
            |..|....|| ||   |.:.|.|....||||.||||.|:||||||||||||||||.:||||||||
Frog    16 SKQHQSPQEN-QTFTGSLKPNQVGETCLYGVPIVSLVIDGQERLCLAQISNTLLKSYSYNEIHNR 79

  Fly    75 RVALGITCVQCTPVQLEILRRAGAMPVSSRRCGMITRREAERLCKSFLGDNTPPRLPDDFAFNVQ 139
            ||||||||||||||||||||||||||:|||||||||:||||||||||||::.||:||::|||:|.
Frog    80 RVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHRPPKLPENFAFDVA 144

  Fly   140 HKCAWGCRGSFLPSRYNSSRAKCIKCSYCGMFFSPNKFIFHSHRITTNDRYVQPDAANFNSWRRH 204
            |:|||||||||:|:||||||||||||:|||::|||||||||||| |.:.:|.|||||||||||||
Frog   145 HECAWGCRGSFIPARYNSSRAKCIKCAYCGLYFSPNKFIFHSHR-TPDSKYTQPDAANFNSWRRH 208

  Fly   205 MSLSGNDYDEKIIHAWEDVKAMFNGGTRKRLVGS---------------SINPRSPGSPTQSTAV 254
            :.|:.....:.:.|:|||||||||||||||...|               .:.|..|..|.::...
Frog   209 LRLNDTTPSDDLSHSWEDVKAMFNGGTRKRAFPSPASSSSSSSSARRHLELAPPPPPPPAKALRG 273

  Fly   255 SSGVGSSSCGSPTSF------ERDTNEVDGKSGSSL-PQRSQIDSQYNY--------------GT 298
            .|....|...:..||      .:..:.|..|.|..| |     ...|.:              |.
Frog   274 PSAEEESGATAARSFPLIPVPSKGFSGVLHKMGPPLFP-----PPPYGFPAFGLCAKKDDGGLGD 333

  Fly   299 VAAAAAVVGV---TAVAAA-TVGVPFNLH-----GSTVLSPLHSLRNERDLSIMPISRNFVVDYM 354
            ...||.:.||   ||.|:. :|..||.:.     |:..:.|...|..::.:.    .::.||.
Frog   334 AGKAAGLPGVFWPTAPASKDSVYPPFPVFWPAAAGALPVPPYTGLTQQQQVP----GKSAVVG-- 392

  Fly   355 WQQKDQHYQQPYARKIPSGDNSDSSLDFDSWVKPDSNNPIPNANSVRTSDN-------------- 405
                     :|...: |||:.::.                |.....|:.|.
Frog   393 ---------EPEEAE-PSGETAEE----------------PTREEERSGDEGRQPGEPLTPRKLR 431

  Fly   406 --CSFN--IK-NESHSSIYGIIKNHKLSGVPNSGLNLSDYNIPSIL-NCSAFK-----PVVASTA 459
              .:|.  :| .||.:.:||   :.:|.|...:    :.|:.|.:| :.|:::     |..|...
Frog   432 YISAFRPVVKAAESLAKLYG---SRELYGAARA----AGYSSPDLLSDTSSYRSASPSPDTADEP 489

  Fly   460 IVST-SLYTRSNESTRTDCNNPAQSTRTTTVLTHN---SISASSHQIVGHKTFSPILGKIHSNPE 520
            .|.. |......||.:.....|..|:..::..:..   |...|...:.|::.::..:..:....:
Frog   490 EVDVESGRFPEEESAQLGSLGPGASSSISSPGSERREPSPGGSPASVAGYEVYAKQMTDLPHLMK 554

  Fly   521 KNRIVSVFASSSTGNADDNDDDDEVVDIETTEDEGKFTVQHADSPKTQYDAIS--GSDSPSRSPS 583
            .|......:||...|.|.|:.|.|  |..:|.:|       .||.|...|..|  ...||..:..
Frog   555 GNSSHQGVSSSYLCNLDPNEQDSE--DSHSTAEE-------LDSRKAFQDPRSHLSHTSPLHTDR 610

  Fly   584 TSTNIDVEQDVDVDIITTDTEDQLELSVGRYSTENTSHSLSFFQAEKIQISDLSPNTKTSSGDNE 648
            .      |:|..:|:            .|....|....:::..:.:|:.:..:....|.   :.|
Frog   611 G------EEDSPIDV------------TGTQFVEKDIENMAKDELQKLLVEQMDLRKKL---ERE 654

  Fly   649 TNTLKDAKGINGNLQILARRKRNKLQKDRCLSKRTVSKCVSDKSLIKGLAANELSSSLQ----IQ 709
            ..:|||      |.|...:|:         |:.|  .:.|....:::....|||....:    ||
Frog   655 FQSLKD------NFQDQMKRE---------LAYR--EEMVQQLQIVRDTLCNELDQERKARYAIQ 702

  Fly   710 Q 710
            |
Frog   703 Q 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fuss	NP_001162829.1	Ski_Sno	25..123	CDD:280577	82/100 (82%)
fuss	NP_001162829.1	c-SKI_SMAD_bind	135..228	CDD:198114	65/92 (71%)
skor1	XP_012814921.1	Ski_Sno	35..128	CDD:367087	80/92 (87%)
		c-SKI_SMAD_bind	140..232	CDD:198114	65/92 (71%)
		PRK10263	<341..>500	CDD:236669	36/197 (18%)
		PKK	626..720	CDD:372134	19/98 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	169	1.000	Domainoid score	I3757
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003480
OrthoInspector	1	1.000	-	-		otm49250
Panther	1	1.100	-	-	O	PTHR10005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2371
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010