DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pho and zgc:162972

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_021323880.1	Gene:	zgc:162972 / 558355	ZFINID:	ZDB-GENE-070424-49	Length:	817	Species:	Danio rerio

Alignment Length:	519	Identity:	129/519 - (24%)
Similarity:	203/519 - (39%)	Gaps:	115/519 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EGNHYDLHRKNAFDRIIHSESK-------------KGDNVINYNIHENDKI---KAADNIFSSKL 78
            |....:.|:|      |||..|             |....|:..||..:|:   :.....|:.|.
Zfish   217 EKTKLERHKK------IHSGEKPYICQHCKKSFTLKQSLDIHMRIHTGEKLYTCQQCGKSFTEKH 275

  Fly    79 KMNPNMSYEMNINCFKNIGYGEN----QETSKVLTNSLSNNDINTEESGVVDKNSPFLTLGTTIL 139
            |:..:|          .|..||.    |:..|..... ...|::|.   :....:||      ..
Zfish   276 KLERHM----------KIHTGEKPYRCQQCGKCFREK-QCLDVHTR---IHTGQNPF------TC 320

  Fly   140 NSNGKSRRWEQKLVHIKTMEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGID----GF 200
            :..|||.|.:|||:...|:..|....:           |.:.::...|.:..|||..:.    ..
Zfish   321 SQCGKSFRLKQKLISHMTVHTEVKPAL-----------GIEIVLFTLDQMDIKEEDCVSQSGTHI 374

  Fly   201 TSQQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNISERILSKTTLSF---- 261
            |.|.:.:.:..|:.||..|..|:.....|::  .|.:...|  .|....||...|.|.:.:
Zfish   375 TEQSSLKIKTGETAFTCKQCGEIFTTNQSLE--SHKVIHTG--EQHYFCSECGKSFTQMRYLKNH 435

  Fly   262 ------EEPILLPDSSSIELVNETAAMTINNHRTLSNHTG-------NTGDLHALPSSVPFRIGL 313
                  :.|...|:....    .|...::.:|  |..|||       :.|....|..|:...:.:
Zfish   436 MKIHAGDHPFTCPECDKC----FTMKHSLESH--LKIHTGEKPFTCPDCGKKFRLKQSLEGHMRI 494

  Fly   314 HEGQ----VNDCLSTISQSTHQDNTDSTGCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAM 374
            |.|:    ..:|..:..:....|            :.:|: :|.:|..:||.  |.|.||....:
Zfish   495 HTGEKPYTCQNCGKSFREKQILD------------THLTI-HTGEKPYSCPE--CGKSFRVKKCL 544

  Fly   375 RKHLHTH-GPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIH 438
            ..|:.|| |.:.:.|.||||:|.....|:||..:||||||:.|  ..||:.|.:..:|:.|||||
Zfish   545 ENHIKTHTGEKPYTCQECGKSFAIKQNLERHMRIHTGEKPYSC--PECGRSFRVKQDLKIHVRIH 607

  Fly   439 TGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNT-SISGKS--GCSNAESNSQSEDTSANY 499
            ||::||.|  ..|.|.|.::..|:||:..|...|... |..||:  |..|.||:.:....|..|
Zfish   608 TGEKPFSC--QQCGKSFTENKKLESHMRIHTGEKPFVCSHCGKNFRGKQNLESHMRLHTGSKPY 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	12/40 (30%)
		C2H2 Zn finger	359..381	CDD:275368	7/21 (33%)
		COG5048	<386..515	CDD:227381	47/117 (40%)
		zf-C2H2	386..408	CDD:278523	9/21 (43%)
		C2H2 Zn finger	388..408	CDD:275368	9/19 (47%)
		zf-H2C2_2	401..426	CDD:290200	12/24 (50%)
		C2H2 Zn finger	416..438	CDD:275368	8/21 (38%)
		zf-H2C2_2	430..457	CDD:290200	14/26 (54%)
		C2H2 Zn finger	446..468	CDD:275368	7/21 (33%)
zgc:162972	XP_021323880.1	COG5048	8..328	CDD:227381	28/136 (21%)
		C2H2 Zn finger	12..32	CDD:275368
		C2H2 Zn finger	40..60	CDD:275368
		C2H2 Zn finger	68..88	CDD:275368
		C2H2 Zn finger	96..116	CDD:275368
		C2H2 Zn finger	124..144	CDD:275368
		C2H2 Zn finger	152..172	CDD:275368
		COG5048	176..603	CDD:227381	102/449 (23%)
		C2H2 Zn finger	180..200	CDD:275368
		C2H2 Zn finger	208..228	CDD:275368	3/16 (19%)
		C2H2 Zn finger	236..256	CDD:275368	2/19 (11%)
		C2H2 Zn finger	264..284	CDD:275368	4/29 (14%)
		C2H2 Zn finger	292..312	CDD:275368	4/23 (17%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		C2H2 Zn finger	391..411	CDD:275368	4/21 (19%)
		COG5048	417..799	CDD:227381	79/278 (28%)
		C2H2 Zn finger	419..439	CDD:275368	4/19 (21%)
		C2H2 Zn finger	447..467	CDD:275368	4/25 (16%)
		C2H2 Zn finger	475..495	CDD:275368	3/19 (16%)
		C2H2 Zn finger	503..523	CDD:275368	3/32 (9%)
		C2H2 Zn finger	531..551	CDD:275368	7/21 (33%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	8/21 (38%)
		C2H2 Zn finger	615..635	CDD:275368	7/21 (33%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		C2H2 Zn finger	671..691	CDD:275368
		C2H2 Zn finger	699..719	CDD:275368
		C2H2 Zn finger	727..747	CDD:275368
		C2H2 Zn finger	755..775	CDD:275368
		C2H2 Zn finger	783..803	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910