DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pho and zxdc

DIOPT Version :9

Sequence 1:	NP_524630.1	Gene:	pho / 43819	FlyBaseID:	FBgn0002521	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_031757030.1	Gene:	zxdc / 100495694	XenbaseID:	XB-GENE-1033000	Length:	869	Species:	Xenopus tropicalis

Alignment Length:	346	Identity:	84/346 - (24%)
Similarity:	131/346 - (37%)	Gaps:	97/346 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 NLSQENNISERILSKTTLSFEEPILLPDSSSIELVNETAAMTI---NNHRTLSNHTGNTGDLHAL 303
            |||:|       .:...::.|..::.|..||...:.....:|:   |...||    |..|.....
Frog    56 NLSEE-------AAAPAVTGEHDLVRPSPSSSSELGLPGYVTVRLENGVLTL----GGRGSESVE 109

  Fly   304 PSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEM---NLSEVTVSYTN--DKKIA----- 358
            |:..|.     ..||:|..:..:.::..:...|:|..:.   :|.:|.:...:  |:::|
Frog   110 PAEPPV-----SNQVSDIQAQPAWASELEAASSSGAAQRFPEDLEDVDLVLRDSMDEQVAGFLVG 169

  Fly   359 -------------------------CPHKGCNKHFRDSSAMRKHL--HTHGPRVHVC--AECGKA 394
                                     ||..||.|.|.....::.||  ||.|.|...|  |.||.:
Frog   170 EIGELQVNLGEALDLARKGVLLVFRCPEPGCAKAFDRKQQLKVHLLSHTEGQRPFKCTVANCGWS 234

  Fly   395 FVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIH--------------------- 438
            |....|||||...|..::||.|...||||.|:..:||:.|::.|
Frog   235 FTTLYKLKRHLQSHDKQRPFSCDVPGCGKSFTTVYNLKAHLKAHEQENLFRCDTCGESFPTATKL 299

  Fly   439 TG--------DRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNTSISGKSGCSNAESNSQSEDT 495
            :|        :||:.|.|..|:|.|...|.|.||...|.: ::...|....||     |.|.:
Frog   300 SGHRRMHFEPERPYKCEFPGCDKTFITVTALFSHHRAHVR-EQEQFICSFPGC-----NKQYD-- 356

  Fly   496 SANYVKVELQDSVTENHVPFV 516
            .|..:|:.|:....|.  ||:
Frog   357 KACRLKIHLRSHTGER--PFI 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pho	NP_524630.1	Transpos_assoc	<342..382	CDD:290671	14/76 (18%)
		C2H2 Zn finger	359..381	CDD:275368	9/23 (39%)
		COG5048	<386..515	CDD:227381	45/159 (28%)
		zf-C2H2	386..408	CDD:278523	10/23 (43%)
		C2H2 Zn finger	388..408	CDD:275368	10/21 (48%)
		zf-H2C2_2	401..426	CDD:290200	12/24 (50%)
		C2H2 Zn finger	416..438	CDD:275368	9/21 (43%)
		zf-H2C2_2	430..457	CDD:290200	12/55 (22%)
		C2H2 Zn finger	446..468	CDD:275368	9/21 (43%)
zxdc	XP_031757030.1	zf-C2H2_8	<193..246	CDD:406359	22/52 (42%)
		C2H2 Zn finger	195..217	CDD:275368	8/21 (38%)
		C2H2 Zn finger	226..248	CDD:275368	10/21 (48%)
		zf-C2H2_8	256..333	CDD:406359	20/76 (26%)
		C2H2 Zn finger	256..278	CDD:275368	9/21 (43%)
		C2H2 Zn finger	286..306	CDD:275368	1/19 (5%)
		C2H2 Zn finger	315..337	CDD:275368	9/21 (43%)
		COG5048	<331..487	CDD:227381	14/55 (25%)
		C2H2 Zn finger	346..368	CDD:275368	7/28 (25%)
		C2H2 Zn finger	376..398	CDD:275368	84/346 (24%)
		C2H2 Zn finger	406..428	CDD:275368
		C2H2 Zn finger	436..458	CDD:275368
		C2H2 Zn finger	469..492	CDD:275371
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910