Protein Alignment CG11360 and MEX3B

DIOPT Version :10

• Sequence 1: NP_651934.2
• Gene: CG11360 / 43810
• FlyBaseID: FBgn0039920
• Length: 628
• Species: Drosophila melanogaster
• Sequence 2: NP_115622.2
• Gene: MEX3B / 84206
• HGNCID: 25297
• Length: 569
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 250/669 - (37%)
• Similarity: 311/669 - (46%)
• Gaps: 217/669 - (32%)

  Fly    45 DDPRTLQLAL-ELSLVGFNDNQNCYAQPAQPLPMPLSARSDFEIGTINSTLPIPSAPNCLLLPNA 108
            ||.|.||||| :|||:|.:.::                                         .|
Human    29 DDQRALQLALDQLSLLGLDSDE-----------------------------------------GA 52

  Fly   109 GAVSSEDRSKKSQNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGR 173
            ....||.| |||.||||||||||||||||||||||||||||||||||||||||||||||||||||
Human    53 SLYDSEPR-KKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGR 116

  Fly   174 KEDVNKAKREILSAADHFSLIRASRKPVSDSQNNGMVGSTTSSGGGAVPRMSGPPCMPGQVTIQV 238
            ||||..|:|||:|||:|||:|||||     ::|..:        .||||   |||.:|||.||||
Human   117 KEDVAMARREIISAAEHFSMIRASR-----NKNTAL--------NGAVP---GPPNLPGQTTIQV 165

  Fly   239 RVPYRVVGLVVGPKGATIKHIQQETQTYIVTPSREKEPIFEVTGLPDNVDTARKQIEAHIALRTG 303
            |||||||||||||||||||.|||:|.||||||||:|||:|||||:|:|||.||::||||||||||
Human   166 RVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEAHIALRTG 230

  Fly   304 --------------------------SGSGSGDAITMQSSDSVDTKEYASLPSLTQILNDDLNSE 342
                                      .|||.|...:..:.....|.......|.....:..|.|.
Human   231 GIIELTDENDFHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTPGRKPFSSYRNDSSSSLGSA 295

  Fly   343 ILSSIY----KNSVPSTQEYANNS-----MKTVVNVSNSVKLVQGHHTGNCFQKSEFAEMEMTAN 398
            ...|.:    .:|..:||..|:.|     :....|.:|       ::.||.:            .
Human   296 STDSYFGGGTSSSAAATQRLADYSPPSPALSFAHNGNN-------NNNGNGY------------T 341

  Fly   399 ITAADILDKRLPGNEVSVPLAKANVANIVFRTTSSKTLSFCP---PTSTS------------ASF 448
            .||         |.|.|||....                 ||   ||...            |.|
Human   342 YTA---------GGEASVPSPDG-----------------CPELQPTFDPAPAPPPGAPLIWAQF 380

  Fly   449 HSNCN---ANILTRSCSSASSTTSTKSTNNSANTPPEILNIWKSISDSIDVDEGIGDSPSIWN-- 508
            ..:..   |..::.||||::|::::                    |.|:....|...:||..|
Human   381 ERSPGGGPAAPVSSSCSSSASSSAS--------------------SSSVVFPGGGASAPSNANLG 425

  Fly   509 -------QPANIIPTAHCSPTISISPTDSLLGMGEHSANQQ--------NLNHAK-----EPIMP 553
                   .|....|  ..||.:.::|     |.|||...::        .|.:|.     ...:|
Human   426 LLVHRRLHPGTSCP--RLSPPLHMAP-----GAGEHHLARRVRSDPGGGGLAYAAYANGLGAQLP 483

  Fly   554 NL-PQKIKGIQVQSNADNFLT----------HRECFVCNENTVTTALVPCGHNMFCMECANHICL 607
            .| |....|....|::.:..:          .|:|.||.|:.|..||||||||:|||||||.||.
Human   484 GLQPSDTSGSSSSSSSSSSSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCMECANRICE 548

  Fly   608 SMDAVCPVCNSIVYHAMRI 626
            ..:..||||::.|..|:||
Human   549 KSEPECPVCHTAVTQAIRI 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11360	NP_651934.2	KH-I_MEX3_rpt1	123..195	CDD:411851	65/71 (92%)
		KH-I_MEX3_rpt2	231..302	CDD:411852	59/70 (84%)
		PEX10	<515..621	CDD:227861	42/129 (33%)
		RING-HC_MEX3	575..627	CDD:438181	31/52 (60%)
MEX3B	NP_115622.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		1/1 (100%)
		KH-I_MEX3_rpt1	66..138	CDD:411851	65/71 (92%)
		KH-I_MEX3_rpt2	158..229	CDD:411852	59/70 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..296		8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..365		12/64 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..514		5/31 (16%)
		RING-HC_MEX3B	512..569	CDD:438381	31/56 (55%)