Protein Alignment Ekar and GLR2.1

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_198062.2
• Gene: GLR2.1 / 832768
• AraportID: AT5G27100
• Length: 901
• Species: Arabidopsis thaliana
• Alignment Length: 968
• Identity: 199/968 - (20%)
• Similarity: 365/968 - (37%)
• Gaps: 213/968 - (22%)

  Fly    25 IGAIFSNQPGM-YNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVC--KLIRV 86
            ||..:||...: .|..|:..|:.|         |||........|:..:...|.....  .:...
plant    40 IGTAYSNMTLLCINMSLSDFYSSH---------PETQTRLVTTVVDSKNDVVTAAAAALDLITNK 95

  Fly    87 GVQAVFSPTDSVLATHINSICDALDIPNIG-----------RSAHDFSINVYPSKQLVNYAFNDV 140
            .|:|:..|..|:.|..:..:.....:|.:.           ||.:.|......|.|:  :|..::
plant    96 EVKAILGPWTSMQAQFMIEMGQKSQVPIVTYSATSPSLASIRSQYFFRATYDDSSQV--HAIKEI 158

  Fly   141 IQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNS- 204
            |:...|.....::..:.            .||..|.:::     ..|.|...:..:..:|..|:
plant   159 IKLFGWREVAPVYVDDT------------FGEGIMPRLT-----DVLQEINVRIPYRTVISPNAT 206

  Fly   205 -NGISILLKNILQQQMNEYKYH---YLFTSFDLETYDLEDFKYNFVNITSFRLVDTADV------ 259
             :.||:.|..::......:..|   .|.:.|..:..::...|..:|.|.:..:.|...:
plant   207 DDEISVELLRMMTLPTRVFVVHLVELLASRFFAKATEIGLMKQGYVWILTNTITDVLSIMNETEI 271

  Fly   260 -------GVKQIL---KDIGLYSHHIFKK-PYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLE 313
                   |||..:   |::..:.....|: |..:|::        .....:|:....|:.::...
plant   272 ETMQGVLGVKTYVPRSKELENFRSRWTKRFPISDLNV--------YGLWAYDATTALALAIEEAG 328

  Fly   314 QSHSLTLLNISCEEENSWDGGLSLINY-------LNAVEWKGLTGPIQFKDGQRVQFKLDLIKLK 371
            .| :||.:.:..:...|...||.:..|       |:.|.::||.|..||.:|:......:::.:.
plant   329 TS-NLTFVKMDAKRNVSELQGLGVSQYGPKLLQTLSRVRFQGLAGDFQFINGELQPSVFEIVNVN 392

  Fly   372 QHSIVKVGEWTPHGHL--NITE-PSMFFDAGSMNVTLVVI------TILETPYVMMHYGKN---- 423
            ......:|.|.....|  |:.: |:......|....|..|      |.:...:.:...||.
plant   393 GQGGRTIGFWMKEYGLFKNVDQKPASKTTFSSWQDRLRPIIWPGDTTSVPKGWEIPTNGKRLQIG 457

  Fly   424 -----------------FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNG 471
                             .|.:..|.||.:|..|.:.:.:.:|...|.:|.        :.|.::.
plant   458 VPVNNTFQQFVKATRDPITNSTIFSGFSIDYFEAVIQAIPYDISYDFIPF--------QDGGYDA 514

  Fly   472 MVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFS--FMNPLAIEI 534
            :|.|:...|.|..|...||:..|...:||:.|:...|:.::  ||..:..|..|  |:.||.:.:
plant   515 LVYQVYLGKYDAVVADTTISSNRSMYVDFSLPYTPSGVGLV--VPVKDSVRRSSTIFLMPLTLAL 577

  Fly   535 WIYVLIAYFLVSLCIYIV-GKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIY 598
            |:..|:::|::.|.:::: .:::|         |.:.   ..|:.|:..|||:. :.|..:|...
plant   578 WLISLLSFFIIGLVVWVLEHRVNP---------DFDG---PGQYQLSTIFWFSF-SIMVFAPRER 629

  Fly   599 PRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTE-ISY------GTL 656
            ..:...|::...|.|..|::..||||:||:.|||:.:...:.|...|.::.| :.|      |.|
plant   630 VLSFWARVVVIIWYFLVLVLTQSYTASLASLLTTQHLHPTVTNINSLLAKGESVGYQSSFILGRL 694

  Fly   657 -DSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRD 720
             |||     |.::.:.:|         ..|.........|  :...|..|.|||...:...:.:.
plant   695 RDSG-----FSEASLVSY---------GSPEHCDALLSKG--QAEGGVSAVLMEVPYVRIFLGQY 743

  Fly   721 CN---LTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETC----T 778
            ||   :.|....:|  |.|...|.|||....||.|||:::|......|.:.|:|..||:|    |
plant   744 CNKYKMVQTPFKVD--GLGFVFPIGSPLVADISRAILKVEESNKANQLENAWFKPIDESCPDPLT 806

  Fly   779 RKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQ---SVVNNKYN 840
            ..:.:.......||.:|...:|  |:|.|:  ..:|..:|.|.|   .:..|:|   .|:..|:|
plant   807 NPDPNPSVSFRQLGFDSFWVLF--LVAAIV--CTMALLKFVYQF---LKENPNQRNLRVLWEKFN 864

  Fly   841 QDGILESERNYTPPDRSFWIEIAEELRYASWCMNKQKRPALTRTCSKCTIPKGQRINK 898
            :            ||:..:|                      :..:||....||.:.|
plant   865 E------------PDQKSYI----------------------KDVTKCQCSSGQGMPK 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	72/409 (18%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	96/409 (23%)
		Lig_chan	532..806	CDD:459656	72/289 (25%)
GLR2.1	NP_198062.2	PBP1_GABAb_receptor_plant	33..411	CDD:380645	71/407 (17%)
		GluR_Plant	452..794	CDD:270404	91/382 (24%)
		Lig_chan	574..833	CDD:459656	73/291 (25%)