Protein Alignment Ekar and grik5

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001315085.1
• Gene: grik5 / 798791
• ZFINID: ZDB-GENE-070821-6
• Length: 1067
• Species: Danio rerio
• Alignment Length: 928
• Identity: 327/928 - (35%)
• Similarity: 496/928 - (53%)
• Gaps: 100/928 - (10%)

  Fly     8 LLFQFLSYG-LGVPP----------LVRIGAIFSNQPGMYNSE-LAFRYAIHRLN--MDKSLLPE 58
            :.|:||... :.:||          .||:.||..:.......| ||...|...:|  |:......
Zfish    11 IYFRFLLVTVVTMPPSSLSQTPVLSSVRMAAILDDSSVCGRGERLALALARENINSVMENPARAR 75

  Fly    59 TTVDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINS-ICDALDIPNIGRSAHD- 121
            ..||.:  .:.:...:||...:|:::..||.:|..|..|..:..|.| ||...:||::.....:
Zfish    76 VEVDIF--ELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICGEKEIPHVKIGPEET 138

  Fly   122 --------FSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQV 178
                    .|:.:|||.:.::.|...:::..::....::..|...::.|.:|.|.|       .:
Zfish   139 PRLPYLRFASVTLYPSNEDLSLAIGSILRSFSYPSASLVCAKAECLLRLEELIRRF-------LI 196

  Fly   179 SRDSY-----------VSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFD 232
            ||::.           ...|.|.:..:|..||||.|::...::||...:..|....|.|:.|:.|
Zfish   197 SRETLSIRMLDDNLDPTPLLKEIRDDKIATIIIDANASISYLILKKASELGMTSAFYKYILTTMD 261

  Fly   233 LETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEP-- 295
            .....|:|......||..|.:.:|......:.::.             |||..::...:...|
Zfish   262 FPLLWLDDIVDEQSNIVGFSMFNTTHPFYLEFIRS-------------LNLSWREGCDINPYPGP 313

  Fly   296 ----ALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK 356
                ||:||:|:|....:|.|.:|..:.:..:||.....|..|.||:|||..||:.||||.::|.
Zfish   314 ALSSALLFDAVHVVVSAVQELNRSQEIGVKPLSCTSPQIWQHGTSLMNYLRMVEYDGLTGRVEFN 378

  Fly   357 D-GQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFDAGS--MNVTLVVITILETPYVM- 417
            . |||..:.|.:::..:....::|.|..:..|.:...|:..:...  .|.:|::.||||.||||
Zfish   379 SKGQRTNYTLHILEKHRGGHKEIGIWYSNNTLLMNSTSLDINVSETLANKSLIITTILENPYVMR 443

  Fly   418 -MHYGKNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKA 481
             ::| :.|.|||::.|||||:|..:|..:.|.|.:.||.|..|||.:| .|.|.|||.:|:..||
Zfish   444 KINY-QEFEGNEQYEGFCVDMLRELSDILKFTYRIKLVDDGLYGAPEP-NGSWTGMVGELINRKA 506

  Fly   482 DLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVS 546
            ||||.:.|||..||.||||:||||.||||||::|........|||::|.:..:|:::|:||..||
Zfish   507 DLAVAAFTITSEREKVIDFSKPFMTLGISILYRVHIGRKPGYFSFLDPFSPAVWLFMLLAYLAVS 571

  Fly   547 LCIYIVGKLSPIEWKCINAC-----DLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRI 606
            ..:::..:|||.||...:.|     ||    :.||::|.:|.||.:|.||||..:|.|||:|||.
Zfish   572 CVLFLSARLSPYEWYNPHPCLRERRDL----LENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRC 632

  Fly   607 ISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIE 671
            :|..|..|:|||::|||||||||||.:||..|||:.:|||.||.|.|||:..|||||||.:|..:
Zfish   633 VSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRYQ 697

  Fly   672 TYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYG 736
            ||:::|..|.:|:||.|..:.|:||.||....||||:||||.:|....:||||||||||||||||
Zfish   698 TYQRMWNYMYSKQPSVFVKSTEEGIARVVNSKYAFLLESTMNEYHRSLNCNLTQIGGLLDTKGYG 762

  Fly   737 IATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFV 801
            |..|.|||:||::|||:|:|||...:::|..:||:.  ..|.::   :..:|..||:|:|||:||
Zfish   763 IGMPLGSPFRDELSLAVLQLQENNRLEILKRRWWEG--GKCPKE---EDHRAKGLGMENIGGIFV 822

  Fly   802 VLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDGILESERNY-TPPDRSFWIEIAEE 865
            |||.|:|:|..||..||.::.|.:.|....:.           |..:|.| :....|...|:..|
Zfish   823 VLICGLIIAVFVAVMEFVWSTRRSAETDEVRP-----------LSCDRQYHSHTTVSVCQEMLTE 876

  Fly   866 LRYASWCMN----KQKRP 879
            .|.|..|..    :::||
Zfish   877 FRNAVSCKKSSRLRRRRP 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	94/396 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	192/375 (51%)
		Lig_chan	532..806	CDD:459656	139/278 (50%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	36..414	CDD:380616	95/399 (24%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:473866	192/375 (51%)