Protein Alignment Ekar and Grid2

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 870
• Identity: 240/870 - (27%)
• Similarity: 434/870 - (49%)
• Gaps: 105/870 - (12%)

  Fly    22 LVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIRV 86
            ::.||||| ::....:.|: ||.|:..||.::.:|....:.:.|.:|:..:.|:.||:.|:|:..
  Rat    26 IIHIGAIF-DESAKKDDEV-FRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQ 88

  Fly    87 GVQAVFSPTDSVLATHINSICDALDIPN--IGRSA----------------HDFSINVYPSKQLV 133
            |:.|:.|......|..:.|:.||:.||:  |.||.                .|::::|.|...|.
  Rat    89 GILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLN 153

  Fly   134 NYAFNDVIQYLNWTRFGILHEKENGIINLHQL--SRSFHG-EVHMRQVSRD-----------SYV 184
            ......|.:|. |.:|.|.::.|..|..:.:.  ..|..| :|.:::|..:           ..:
  Rat   154 EVILRVVTEYA-WQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRI 217

  Fly   185 SALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNIT 249
            ..||.:: ..:...|:..|.......:..:::..:..:..|::..:.::...|:::
  Rat   218 EELNRYR-DTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQE--------- 272

  Fly   250 SFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTI----------LESEPALMFDSVYV 304
               || ...:|...|::.......:|.::.:...|...||:          :|.....::|:|.:
  Rat   273 ---LV-RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLL 333

  Fly   305 FAIGL-QTLEQSHSLTLLNISCEEENS--WDGGLSLINYLNAVEWKGLTGPIQF-KDGQRVQFKL 365
            .|... :.||.....::.::||..:||  |.||.|::..:......||||.::| ::|.......
  Rat   334 LANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHF 398

  Fly   366 DLIKLKQ-----HSIVKVGEWTPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNFT 425
            :::....     ..:.|:|.|.|...||.:......:.....|.|.|:|:||.|:||:  .:|..
  Rat   399 EILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMV--SENVL 461

  Fly   426 GN-ERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMT 489
            |. :::.||.:|:|:.:|..:||:|.:.:.||.|||:.. |.|.|||:|.:|:..:||:.:.::|
  Rat   462 GKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQ-EDGTWNGLVGELVFKRADIGISALT 525

  Fly   490 ITYARESVIDFTKPFMNLGISILFKVPTSEPT-RLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVG 553
            ||..||:|:|||..:|:..:.:|.:  .:|.| .:|:.:.|..:.:|..:.....||.|.:|::.
  Rat   526 ITPDRENVVDFTTRYMDYSVGVLLR--RAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLN 588

  Fly   554 KLSPIEWKCINACDLENISIGNQFSLT--DSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSL 616
            .|:|           ..:.:|:..|.|  :|.||..|:|:||..::....::||::...|..|:|
  Rat   589 WLNP-----------PRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFAL 642

  Fly   617 IIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGT-LDSG--------STMTFFRDSVIET 672
            |:::|||||||||||..|:.:.|::.:||:.||:|.||| |||.        ....|.|||:
  Rat   643 IVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSM--- 704

  Fly   673 YKKIWRSMDNKKPSAFTTTYED--GIKRVNQGNYAFLMESTMLDYIV--QRDCNLTQIGGLLDTK 733
            |.::|| |.|:...:.....|.  ||::|..|||||:.::.:|:|:.  ..||:...:|..:..:
  Rat   705 YSQMWR-MINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADR 768

  Fly   734 GYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGG 798
            |||||...|||:||..|..|||||:.||:.:|..|||....:.....:...:.|..:|.::|:.|
  Rat   769 GYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAG 833

  Fly   799 VFVVLIAGIIVAAVVAFFEFWYNFR 823
            ||.:|.|||:::.::|..|.|::.|
  Rat   834 VFCILAAGIVLSCLIAVLETWWSRR 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	86/416 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	139/385 (36%)
		Lig_chan	532..806	CDD:459656	99/288 (34%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		66/335 (20%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	86/417 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	139/385 (36%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007