Protein Alignment Ekar and grin2bb

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001121809.1
• Gene: grin2bb / 559976
• ZFINID: ZDB-GENE-061207-27
• Length: 1770
• Species: Danio rerio
• Alignment Length: 872
• Identity: 218/872 - (25%)
• Similarity: 379/872 - (43%)
• Gaps: 198/872 - (22%)

  Fly    65 VEYV--NRFDSFETVQKVCKLI-RVGVQAVFSPTDS---VLATHINSICDALDIPNIG------- 116
            ||.|  |..|....:.::|.|: |..:|.|....|:   .:|..::.|.....||.:|
Zfish   142 VELVTMNETDPKSIINRICALMSRNWLQGVVFGDDTDQEAIAQILDFISAQTHIPILGIRGGSSM 206

  Fly   117 ----RSAHDFSINVYPS-KQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMR 176
                :..|.......|| :|..:...|.:.:| :|..|.|:.....|    ||
Zfish   207 IMAAKDDHSMFFQFGPSIEQQASVMLNIMEEY-DWYIFSIVTTYYPG----HQ------------ 254

  Fly   177 QVSRDSYVSAL-----NEFKGKEIHNIII------DTNSNGISILLKNILQQQMNEYKYHYLF-- 228
                 .:|:.:     |.|.|.|:..:::      |.:|.         :|.||.:.:...:.
Zfish   255 -----DFVNRIRSTVDNSFVGWELEEVLLLDMSVDDGDSK---------IQNQMKKLQSPVILLY 305

  Fly   229 -------TSFDL-ETYDLEDFKYNFVNITSFRLVDTADV------GVKQILKDIGLYSHHIFKKP 279
                   |.|:: .:..|..:.|.:: :.|....||.:|      |:..:..|...|.
Zfish   306 CTKEEATTIFEVAHSVGLTGYGYTWI-VPSLVAGDTDNVPNVFPTGLISVSYDEWDYG------- 362

  Fly   280 YLNLHIKKSTILESEPALMFDSVYVFAIGLQTL---EQSHSLTLLNISC----EEENSWDGGLS- 336
                       ||   |.:.|:|.:.|:...|:   ...|  |||...|    :::.|..|..:
Zfish   363 -----------LE---ARVRDAVAIIAMATSTMMLDRGPH--TLLKSGCHGAPDKKGSKSGNPNE 411

  Fly   337 LINYLNAVEWKGLTGPIQF-KDGQRVQFKLDLIKL-KQHSIVKVGEWTPHGHLNI-----TEPSM 394
            ::.||..|.::|..  :.| :||.::..||.:|.| |:....:||:| .:|.|.:     ....:
Zfish   412 VLRYLMNVTFEGRN--LSFSEDGFQMHPKLVIILLNKERQYERVGKW-ENGSLAMKYHVWPRFEL 473

  Fly   395 FFDAGSM-NVTLVVITILETPYVMMH-----YG---------------KNFTGNERFY------G 432
            :.||... :..|.::|:.|.|:|::.     .|               :|.||:...|      |
Zfish   474 YSDAEEREDDHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQLKLQNLTGDSGIYIKRCCKG 538

  Fly   433 FCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESV 497
            ||:|||:.|::.|.|.|.|.||.:.|:|.|  ..|.|||||.:::...|.:||||:||...|..|
Zfish   539 FCIDILKKIAKSVKFTYDLYLVTNGKHGKK--INGTWNGMVGEVVLKNAHMAVGSLTINEERSEV 601

  Fly   498 IDFTKPFMNLGISILFKVP--TSEPTRLFSFMNPLAIEIWIYVLIAYFLVS-LCIYIVGKLSPIE 559
            |||:.||:..|||::....  |..|:   :|:.|.:.::|:.:.:...:|| :.:::....||:.
Zfish   602 IDFSVPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVG 663

  Fly   560 WKCINACDLENISIGN-QFSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASY 622
            :   |.|..:....|. .|::..:.|...| .|....|...|:..:::|:.|.|.||::|.:|||
Zfish   664 Y---NRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASY 725

  Fly   623 TANLAAFLTTERMINPIENAEDLASQ------TEISYGTLDSGSTMTFFRDSVIETYKKIWRSMD 681
            |||||||:..|..::.:....|...|      ....:||:.:|||....|::    ||::
Zfish   726 TANLAAFMIQEEYVDQVTGLSDKKFQHPNDFSPPFRFGTVPNGSTERNIRNN----YKEM----- 781

  Fly   682 NKKPSAFTTTYEDGIKRVNQGNY--------AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKG 734
                .::.|::..  |.||:..:        ||:.::.:|:|:..||  |.|..||.  :..|.|
Zfish   782 ----HSYMTSFHQ--KNVNEALHSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTG 840

  Fly   735 YGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGV 799
            ||||..|.|.|:..:.||||:|...|:::.|...|.     |....|...:..::.|.::::.||
Zfish   841 YGIAIQKDSGWKRAVDLAILQLFGDGEMEELEALWL-----TGICHNEKNEVMSSQLDVDNMAGV 900

  Fly   800 FVVLIAGIIVAAVVAFFE--FWYNFRY 824
            |.:|.|.:.::.:....|  |::..|:
Zfish   901 FYMLGAAMALSLITFIAEHLFYWQLRF 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	80/384 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	125/417 (30%)
		Lig_chan	532..806	CDD:459656	79/294 (27%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..465	CDD:380601	80/380 (21%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	126/427 (30%)
		NMDAR2_C	919..1770	CDD:463148	2/9 (22%)