Protein Alignment Ekar and grik4

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_021322088.1
• Gene: grik4 / 556582
• ZFINID: ZDB-GENE-070821-5
• Length: 965
• Species: Danio rerio
• Alignment Length: 867
• Identity: 316/867 - (36%)
• Similarity: 478/867 - (55%)
• Gaps: 69/867 - (7%)

  Fly     1 MLIASGFLLF--QFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLN--MDKSLLPETT 60
            ||.|...|||  .::......|...||.||..:.......| ||...|...:|  .::|...:..
Zfish     1 MLAAWAPLLFLAMWVRNATSGPLSFRIAAILDDPMECSRGERLAITLAKDSINRSSNRSTTGKLE 65

  Fly    61 VDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATH-INSICDALDIPNIGRSAHDF-- 122
            ||.:  .:.|...:||.:.:|:::..||.||..|:.|..:.. |::||...::|.:..:..|.
Zfish    66 VDIF--ELLRDSEYETGETMCQIMSKGVVAVLGPSASPASNSIISNICGEKEVPYVKVAPEDILK 128

  Fly   123 -------SINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHM 175
                   ::::.|:...::.|...::.:.|.:...::..:.:.::||..|.|.|     ...|.|
Zfish   129 VQFPRFTTLDLRPTNTDISMAVAGLLTFFNSSTSCLICAQADCLLNLEVLLRQFLISKETLSVRM 193

  Fly   176 RQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLED 240
            ...|:|. ...|.|.:..:...||:|.|:....::|:...:..|....|.|:.||.:.....|:|
Zfish   194 LDDSQDP-TPLLKEIRDDKTATIIVDANATMSHVILERASELGMLSVYYTYILTSLEFSLLRLDD 257

  Fly   241 FKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEP--------AL 297
            .....|||..|.:.:.               :|..|:...|:|:.......:..|        ||
Zfish   258 LADQRVNIVGFSVFNR---------------THPFFQDFVLSLNRSWQENCDHAPFAGTPLSSAL 307

  Fly   298 MFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRV 361
            :||:|:.....:|.|.:|.::....:||:....|:.|.||:|||..||.:||||.|:|.. |||.
Zfish   308 LFDAVHTVVAAVQELNRSQNVGATQLSCKSSKIWEHGTSLMNYLRMVELEGLTGHIEFNSKGQRS 372

  Fly   362 QFKLDLIKLKQHSIVKVGEWTPHGHLNITE--PSMFFDAGSMNVTLVVITILETPYVMMHYG-KN 423
            .:.|.:::..:..:.::|:|.....|::..  ||:.......|.||.:.||||.||||:... :.
Zfish   373 NYALRIMQNSRDGLRQIGQWHSEQGLSMERKLPSLNVTDTLFNTTLTITTILENPYVMLRANHQE 437

  Fly   424 FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSM 488
            ..||:|:.|||||:|:.::..:.|.|.:.||.|..||... ..|.|.|||.:|:..||||||.::
Zfish   438 LEGNDRYEGFCVDMLKELADILKFKYRIRLVGDGVYGVPG-ANGTWTGMVGELISRKADLAVAAL 501

  Fly   489 TITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVG 553
            |||..||.||||:||||.|||||:::|........|||::|.:..:|:::|:||..||..:::|.
Zfish   502 TITAEREKVIDFSKPFMTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVA 566

  Fly   554 KLSPIEW----KCINA-CDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGF 613
            :|:|.||    .|:.. |.|    :.||:||.:||||.:|.||||...|.|||:|||.:|..|..
Zfish   567 RLTPYEWYNPHPCLKGRCSL----LINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWA 627

  Fly   614 FSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWR 678
            |:|||::|||||||||||.:||..|||:.:|||.||.|.|||:..|||||||::|..:||:::|.
Zfish   628 FTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTMTFFQNSRYQTYQRMWN 692

  Fly   679 SMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGS 743
            .|.:|:||.|..:.|:||.||...|||:|:||||.:|..||:|||||||||||||||||..|.||
Zfish   693 FMYSKQPSVFVKSTEEGIARVLNSNYAYLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPLGS 757

  Fly   744 PWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGII 808
            .:||:..||||.|||...:::|..|||..  ..|.::   :..:|..||:|:|||:||||:.|::
Zfish   758 VYRDEFDLAILRLQEENRLEILKRKWWDG--GKCPKE---EDHRAKGLGMENIGGIFVVLVCGLL 817

  Fly   809 VAAVVAFFEFWYNFRYNYEATP 830
            ||..:|..||.:..|:    ||
Zfish   818 VAIFMAVLEFVWMLRH----TP 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	94/392 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	191/374 (51%)
		Lig_chan	532..806	CDD:459656	142/278 (51%)
grik4	XP_021322088.1	Periplasmic_Binding_Protein_type1	24..401	CDD:471960	94/394 (24%)
		PBP2_iGluR_kainate_KA1	425..785	CDD:270442	185/364 (51%)