Protein Alignment Ekar and Gria1

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_113796.1
• Gene: Gria1 / 50592
• RGDID: 621531
• Length: 907
• Species: Rattus norvegicus
• Alignment Length: 886
• Identity: 319/886 - (36%)
• Similarity: 487/886 - (54%)
• Gaps: 84/886 - (9%)

  Fly    16 GLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKV 80
            |...|..::||.:|.||....::  |||:|:.:|.....|||:      ::.||..||||...:.
  Rat    18 GANFPNNIQIGGLFPNQQSQEHA--AFRFALSQLTEPPKLLPQ------IDIVNISDSFEMTYRF 74

  Fly    81 CKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHDFSINVYPSKQLVNYAFNDV 140
            |.....||.|:|...:......:.|.|.||.:..|..|     ::.|.:.:.|..|   .|...:
  Rat    75 CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQ---EALISI 136

  Fly   141 IQYLNWTRFGILHEKENGIINLHQLSRSFHGE------VHMRQVSRDSYVSALNEFKGKEIHNII 199
            |.:..|..|..:::.:.|:..|.::..:...:      |::...:.:.|.....:.:.|:...::
  Rat   137 IDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVV 201

  Fly   200 IDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQI 264
            :|..|..::.:|..|::.:.|...|||:..:......||..||.:..|:|.|:||:..|....:|
  Rat   202 VDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARI 266

  Fly   265 LK-----DIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNIS 324
            ::     |...::...:|:|       |.|     .||.:|.|.|.|...|:|.:..    ::||
  Rat   267 MQQWRTSDSRDHTRVDWKRP-------KYT-----SALTYDGVKVMAEAFQSLRRQR----IDIS 315

  Fly   325 -------CEEENS--WDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVG 379
                   |....:  |..|:.:...|..|.::||||.:||.: |:|..:.|.:|::|...|.|:|
  Rat   316 RRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIG 380

  Fly   380 EWTPHGHLNITEPSMFFDAGS-----------MNVTLVVITILETPYVMMHYGKN-FTGNERFYG 432
            .|        .|...|..|.:           .|.|.:|.||||.||||:....| |.||:|:.|
  Rat   381 YW--------NEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEG 437

  Fly   433 FCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESV 497
            :||::...|::.||:.|.|::|.|.||||:||:|..|||||.:|:..:||:||..:|||..||.|
  Rat   438 YCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEV 502

  Fly   498 IDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW-- 560
            |||:||||:|||||:.|.|......:|||::|||.|||:.::.||..||:.:::|.:.||.||
  Rat   503 IDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHS 567

  Fly   561 -KCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTA 624
             :.....|.......|:|.:.:|.||::|.||||..||.||::|.||:...|.||:|||::||||
  Rat   568 EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 632

  Fly   625 NLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFT 689
            |||||||.|||::|||:|||||.||||:||||::|||..|||.|.|..::|:|..|.:.:||.|.
  Rat   633 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFV 697

  Fly   690 TTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWRDKISL 751
            .|.|:|:.||  ::|.||:|:||||.:||.|| .|:..::||.||:|||||||||||..|:.::|
  Rat   698 RTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNL 762

  Fly   752 AILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFF 816
            |:|:|.|:|.:..|.:|||.:..| |.......:.|.::|.|.::.|||.:||.|:.:|.:||..
  Rat   763 AVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALI 826

  Fly   817 EFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRS 857
            ||.|..|...:......::    .|..|.|:.|..|.|..|
  Rat   827 EFCYKSRSESKRMKGFCLI----PQQSINEAIRTSTLPRNS 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	96/391 (25%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	192/375 (51%)
		Lig_chan	532..806	CDD:459656	134/279 (48%)
Gria1	NP_113796.1	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	98/400 (25%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	194/381 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		3/7 (43%)
		PDZ-binding	904..907