Protein Alignment Ekar and gria4a

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_999971.1
• Gene: gria4a / 407735
• ZFINID: ZDB-GENE-020125-7
• Length: 898
• Species: Danio rerio
• Alignment Length: 907
• Identity: 327/907 - (36%)
• Similarity: 485/907 - (53%)
• Gaps: 109/907 - (12%)

  Fly    13 LSYGLG---VPPLVRIGAIF-SNQPGMYNSELAFRYAI--HRLNMDKSLLPETTVDYYVEYVNRF 71
            |.:|||   .|..|:||.:| .|....|.   |||.||  |..:.:.:..|...|. :|:.:...
Zfish     9 LLWGLGEGAFPSSVQIGGLFIRNTDQEYT---AFRLAIFLHNTSPNATEAPFNLVP-HVDNIETA 69

  Fly    72 DSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDI-------PNIGRSAHDFSINVYPS 129
            :||......|.....||.|:|...|......:.|.|.||.|       |..|.:  .|.:.:.||
Zfish    70 NSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLVTPSFPAEGET--QFVLQLRPS 132

  Fly   130 KQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGE-------VHMRQVSRDSYVSAL 187
               :..|...::.:.:|:||..|::.:.|...|..:... .|:       :.:...:..||...|
Zfish   133 ---IRGALLSLLDHYDWSRFVFLYDTDRGYAVLQAIMEK-AGQNGWQVSAICVENFNDASYRRLL 193

  Fly   188 NEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYK----YHYLFTSFDLETYDLEDFKYNFVNI 248
            .:...::....:||..:.    .|:|||:|.::..|    |||:..:...:...||.|.:...|:
Zfish   194 EDLDRRQEKKFVIDLEAE----RLQNILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANV 254

  Fly   249 TSFRLVDTADVGVKQILKDIGLYSHHIFKKPYL--------NLHIKKSTILESEP----ALMFDS 301
            |.|:|||                    |.||.:        .|..::....||.|    :|.:|.
Zfish   255 TGFQLVD--------------------FSKPMVIKLMQRWNKLDQREYPGSESPPRYTSSLTYDG 299

  Fly   302 VYVFAIGLQTLEQSHSLTLLNIS---------CEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD 357
            |.|.|...:.|.:..    ::||         ......|:.|:.:...|..|..:||||.|||..
Zfish   300 VLVMAEAFRNLRRQK----IDISRRGNAGDCLANPAAPWNQGIDMERTLKQVRIQGLTGNIQFDH 360

  Fly   358 -GQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNI--TEPSMFFDAGSMNVTLVVITILETPYVMMH 419
             |:||.:.:|:.:||.:...|:|.|.....|.:  .|.||..|:...|.|::|.||:|.||||:.
Zfish   361 YGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELSMGNDSAMENRTVIVTTIMEGPYVMLK 425

  Fly   420 YGKN---FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKA 481
              ||   :.|||:|.|:|||:...:::.:|..|.:.:|.|.||||:||||..|||||.:|:..||
Zfish   426 --KNWEMYEGNEQFEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETKIWNGMVGELVYGKA 488

  Fly   482 DLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVS 546
            ::||..:.||..||.||||:||||:|||||:.|.|......:|||::|||.|||:.::.||..||
Zfish   489 EIAVAPLAITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS 553

  Fly   547 LCIYIVGKLSPIEWKCINACDLENISIG-------NQFSLTDSFWFTIGTFMQQSPDIYPRAMST 604
            :.:::|.:.||.||   :..:.|..|.|       |:|.:.:|.||::|.||||..|..||::|.
Zfish   554 VVLFLVSRFSPYEW---HTEEPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSG 615

  Fly   605 RIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSV 669
            ||:...|.||:|||::|||||||||||.|||::|||:|||||.||||:|||||||||..|||.|.
Zfish   616 RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSK 680

  Fly   670 IETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLLD 731
            |..|:|:|..|.:.:|:.||.|..:|:.||  ::|.||||:||||.:|..|| .|:..::||.||
Zfish   681 IAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLD 745

  Fly   732 TKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESI 796
            :||||:||||||.....::||:|:|.|.|.:..|.:|||.:..|...:.:.||...:.:|.|.::
Zfish   746 SKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKSSQALSLSNV 810

  Fly   797 GGVFVVLIAGIIVAAVVAFFEFWYNFR---YNYEATPSQSVVNN-KYNQDGIL-ESERNYTP 853
            .|||.:|:.|:.:|.:||..||.|..|   ...:.|.|:::.|. :.:..|.| |:.|..||
Zfish   811 AGVFYILVGGLGLAMLVALVEFCYKSRAEAKKLKLTFSEAMRNKARLSITGSLGENGRVLTP 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	99/410 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	191/381 (50%)
		Lig_chan	532..806	CDD:459656	134/283 (47%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..395	CDD:380611	99/409 (24%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	192/386 (50%)