Protein Alignment Ekar and gria1b

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_991293.1
• Gene: gria1b / 403044
• ZFINID: ZDB-GENE-020125-2
• Length: 917
• Species: Danio rerio
• Alignment Length: 894
• Identity: 309/894 - (34%)
• Similarity: 473/894 - (52%)
• Gaps: 112/894 - (12%)

  Fly     1 MLIASGFLLFQFLSYGL----GVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTV 61
            :|:.:|.|       ||    ..|..:.||.:|......|:   .||:|:.:.|....|:|:
Zfish     6 VLLLTGLL-------GLCSCSSFPSNINIGGLFPTDSHEYD---VFRFALSQHNDVPKLVPQ--- 57

  Fly    62 DYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHD 121
               |:.|:...||......|.....||.|:....|......:.|.|.||.:..:..|     .:.
Zfish    58 ---VDMVDTGSSFAMTYAFCSQFSKGVYAIIGLYDRKTMNMLMSFCGALHVCFVTPSFPIDTNNQ 119

  Fly   122 FSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL-----SRSFH-GEVHMRQVSR 180
            |.|.:.|..|   .|...::::..|.:|..::..::|:..|.::     .:::. ..::...::.
Zfish   120 FVIQLRPELQ---DALIALVEHYKWNKFVYMYSSDSGLTVLQKILDTAAEKTWQVTSINFDTLTE 181

  Fly   181 DSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNF 245
            .:::.|:.:...|:...||:|.....::.:|..|..|:.|...|||:..:......:|.:|:...
Zfish   182 AAFLKAIQDLDNKKEFKIILDCELERLNSILNLIAAQKKNLKNYHYILANLGFLDLNLTEFRKGG 246

  Fly   246 VNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQ 310
            .|:|.|:|::..:..|.:.::|...:.....|.|      |:.  |:...||.:|.|.|.|...|
Zfish   247 ANVTGFQLMNYTNPTVSRTIQDWLEFDSKDLKSP------KRR--LKYTGALTYDGVTVMATAFQ 303

  Fly   311 TLEQSHSLTLLNIS---------CEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKL 365
            .|.:..    ::||         ......|..|:.:...|..|:::||||.:||.| |.|..|.:
Zfish   304 NLRKQR----IDISRRGNAGECLANPPAPWGQGIDIQRALQQVQFEGLTGHVQFNDKGHRTNFTV 364

  Fly   366 DLIKLKQHSIVKVGEW----------TPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMMHY 420
            .:::.......|||.|          |....||.|       .|..|.|.||.||||.||||:.
Zfish   365 SVMEFGPSGPKKVGYWNQREKYVSTATYSNMLNET-------FGLQNRTYVVTTILEAPYVMLK- 421

  Fly   421 GKN---FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKAD 482
             ||   ..||:::.|:||::...|::.||:.|.|:||.|.||||:|.||..|||||.:|:..|||
Zfish   422 -KNHEQLVGNDKYEGYCVELAAEIAKHVGYSYRLELVGDGKYGARDAETMMWNGMVGELVYGKAD 485

  Fly   483 LAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSL 547
            :||..:|||..||.||||:||||:|||||:.|.||.....:|||::|||.|||:.::.||..||:
Zfish   486 VAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSV 550

  Fly   548 CIYIVGKLSPIEWKCIN---ACDLENIS---------------------------IGNQFSLTDS 582
            .:::|.:.||.||...:   ..|.:|.:                           ..|:|.:.:|
Zfish   551 VLFLVSRFSPYEWHADDEEETADQQNQNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNS 615

  Fly   583 FWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLAS 647
            .||::|.||||..||.||::|.||:...|.||:|||::|||||||||||.|||::|||:|||||.
Zfish   616 LWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 680

  Fly   648 QTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMES 710
            ||||:|||||.|||..|||.|.|..::|:|..|.:.:|:.|..|.::|:.||  ::|.||:|:||
Zfish   681 QTEIAYGTLDGGSTKEFFRRSKIAVFEKMWSYMKSAEPTVFVKTTDEGVVRVRKSKGKYAYLLES 745

  Fly   711 TMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTD 774
            ||.:||.|| .|:..::||.||:||||:||||||..|:.::||:|:|.|:|.:..|.:|||.:..
Zfish   746 TMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKG 810

  Fly   775 ETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR 823
            | |.......:.|.::|.|.::.|||.:||.|:.:|.:||..||.|..|
Zfish   811 E-CGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSR 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	88/396 (22%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	194/404 (48%)
		Lig_chan	532..806	CDD:459656	133/306 (43%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..390	CDD:380613	85/387 (22%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	196/410 (48%)