Protein Alignment Ekar and Ir75a

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 750
• Identity: 140/750 - (18%)
• Similarity: 275/750 - (36%)
• Gaps: 192/750 - (25%)

  Fly   131 QLVNYAFNDVIQYLNWTRFG---ILH--EKENGIINLHQLSRS------FHGEVHMRQVSRDSYV 184
            ||.|:..::::|    :|.|   :.|  :.:..:....|..:.      :|..|.||.|...|::
  Fly     5 QLANFVLDNLVQ----SRIGFIVLFHCWQSDESLKFAQQFMKPIHPILVYHQFVQMRGVLNWSHL 65

  Fly   185 SALNEFKGKEIHN-----IIIDTNSNGISILLKNILQQQMNEYKYHYLF--TSFDLETYDLEDFK 242
            ..  .:.|   |.     |.:|...:....||:...::|:....||:|.  ....||.|||
  Fly    66 EL--SYMG---HTQPTLAIYVDIKCDQTQDLLEEASREQIYNQHYHWLLVGNQSKLEFYDL---- 121

  Fly   243 YNFVNITSFRLVDTADVG-VKQILKD----IGLYSHHIFKKPYL---NLHIKKSTILESEPALMF 299
            :...||:    :| |||. ||:.::|    :....|.::....:   .|::..|..:..:|.:
  Fly   122 FGLFNIS----ID-ADVSYVKEQIQDNNDSVAYAVHDVYNNGKIIGGQLNVTGSHEMSCDPFV-- 179

  Fly   300 DSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFK 364
                        ..::..|:    |.::.:.:.....|.:.:..|.......|:...|.:.::|
  Fly   180 ------------CRRTRHLS----SLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRF- 227

  Fly   365 LDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNFTGNER 429
                 |.|.:...:......|               .::||::..:|       |....|..::.
  Fly   228 -----LSQENDTHIDSLARFG---------------FHLTLILRDLL-------HCKMKFIFSDS 265

  Fly   430 FYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYAR 494
            :                              :|....|   |.|..::...|||   :.|.:.|.
  Fly   266 W------------------------------SKSDVVG---GSVGAVVDQTADL---TATPSLAT 294

  Fly   495 ESVIDFTKPFMNLGI--SI-LFKVPTSEPTRLFSFMNPLAIEIW-----IYVLIAYFLVSLCIYI 551
            |..:.:....:..|.  |: :|:.|.:...|...|:.|.:..:|     :..||. .|:.:..|:
  Fly   295 EGRLKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIG-VLLWITFYM 358

  Fly   552 VGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSL 616
            ..|.....|:      |:.:.     ||..:|..:.|....||..:.||:...|:|.......|.
  Fly   359 ECKRMQKRWR------LDYLP-----SLLSTFLISFGAACIQSSSLIPRSAGGRLIYFALFLISF 412

  Fly   617 IIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVI-ETYKKIWRSM 680
            |:...||:.:.:.|.:..:.:.|:....|| ::.::.|......|.::...|.: |.:..|.|.:
  Fly   413 IMYNYYTSVVVSSLLSSPVKSKIKTMRQLA-ESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKI 476

  Fly   681 DN--KKPSAFTTTYEDGIKRV--NQGNYAFLME-STMLDYI-----VQRDCNLTQIGGLLDTKGY 735
            ::  :.|..:... |.|:.||  |.| |.::.| |:...|:     .|..|:|.::
  Fly   477 ESQTQNPELWLPA-EQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEV--------- 530

  Fly   736 GIATP---------KGSPWRDKISLAILELQERGDIQMLYDK---WWKNTDETCTRKNTSKQSKA 788
             :..|         :.|.:::...|..|.:.|.|    :|.|   :|.:....|..:|.     .
  Fly   531 -LFRPEQLFYTHLHRNSTYKELFRLRFLRILETG----VYRKQRSYWVHMKLHCVAQNF-----V 585

  Fly   789 NSLGLESIGGVFVVLIAGIIVAAVVAFFEF-WYNF 822
            .::|:|.:..:.::||...|:..|:...|. |..|
  Fly   586 ITVGMEYVAPLLLMLICADILVVVILLVELAWKRF 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	52/284 (18%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	76/399 (19%)
		Lig_chan	532..806	CDD:459656	61/301 (20%)
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	27/132 (20%)