Protein Alignment Ekar and gria3b

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_938174.1
• Gene: gria3b / 368416
• ZFINID: ZDB-GENE-030616-53
• Length: 883
• Species: Danio rerio
• Alignment Length: 900
• Identity: 310/900 - (34%)
• Similarity: 476/900 - (52%)
• Gaps: 88/900 - (9%)

  Fly     7 FLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPET-TVDYYVEYVNR 70
            |||:.|.:...|.|..:.||.:|.......:|  |||:|:...|.::::..:. .::|.|:.:..
Zfish     8 FLLWLFGTSLAGFPNQINIGGLFMRSTVQEHS--AFRFAVQLYNTNQNMTEKPFHLNYNVDNLES 70

  Fly    71 FDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRSAHDFSINVYPSKQLVNY 135
            .:||......|.....||.|:|...|......:.|.|.||..        .|....||....|.:
Zfish    71 SNSFSVTHAFCSQFSRGVYAIFGFYDKKSMNTLTSFCGALHT--------SFVTPSYPIDSDVQF 127

  Fly   136 ----------AFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF---HGEVHMRQVSR----DSY 183
                      |...::.:..|.:|..|::.:.|...|..:..:.   :.:|..|.|..    ..:
Zfish   128 VIQMRPPLKGAVLSLLSHYKWDKFVYLYDTDRGFSILQAIMEAAVANNWQVTARSVGSITDPQEF 192

  Fly   184 VSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNI 248
            ...:.|...::....:||...:.|:::|:.::....|...|||:..:.......|:.......||
Zfish   193 RRIIEEMDRRQEKRYLIDCEVDRINVILEQVVTLGKNSRGYHYIIANLGFTNISLDKVFLGGANI 257

  Fly   249 TSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLE 313
            :.|::::..::.|:|.|:.........|.:       .|:|.|:...||.:|::.|.|...:.|.
Zfish   258 SGFQIINPENLVVQQFLQRWDRLDEREFPE-------AKNTPLKYTSALSYDAILVIAEAFRYLR 315

  Fly   314 QSHSLTLLNISCEEENS-----------WDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLD 366
            :.      .:......|           |..|:.:...|..|:.:|:||.|||.. |:|..:.:|
Zfish   316 RQ------RVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRTNYTID 374

  Fly   367 LIKLKQHSIVKVGEWTP-HGHLNITEPSMFFDAGSM-NVTLVVITILETPYVMMHYGKN---FTG 426
            :.::|.....|:|.|.. ...:||.:.....|:.|: |.|:||.||:|.||||  |.||   ..|
Zfish   375 VYEMKTGGPRKIGYWNEFERFVNIMDQQFTNDSSSVENRTIVVTTIMEAPYVM--YKKNHMHLEG 437

  Fly   427 NERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTIT 491
            ||::.|:|||:...|::.||..|.|.:|.|.||||:||||..|||||.:|:..:||:||..:|||
Zfish   438 NEKYEGYCVDLASEIAKHVGIKYRLSIVMDGKYGARDPETKSWNGMVGELVYGRADIAVAPLTIT 502

  Fly   492 YARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLS 556
            ..||.||||:||||:|||||:.|.|......:|||::|||.|||:.::.||..||:.:::|.:.|
Zfish   503 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 567

  Fly   557 PIEWKCINACDLENISI----GNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLI 617
            |.||:.....::::...    .|.|.:.:|.||::|.||||..||.||::|.||:...|.||:||
Zfish   568 PYEWQLDETDEVKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 632

  Fly   618 IVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDN 682
            |::|||||||||||.|||::|||:|||||.||||:|||||||||..|||.|.|..|:|:|..|.:
Zfish   633 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKS 697

  Fly   683 KKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSP 744
            .:||.|..|..||:.||  ::|.:|||:||||.:||.|| .|:..::||.||:||||:||||||.
Zfish   698 AEPSVFAKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSA 762

  Fly   745 WRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIV 809
            .|:.::||:|:|.|:|.:..|.:|||.:..| |.......:.|.::|.|.::.|||.:|:.|:.:
Zfish   763 LRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDKTSALSLSNVAGVFYILVGGLGL 826

  Fly   810 AAVVAFFEFWYNFR------------YNYEATPSQSVVN--------NKYNQDGI 844
            |.:||..||.|..|            .||:..|..:..|        |.|..:.:
Zfish   827 AMMVALIEFCYKSRAEAKRLKLEKNAQNYKPAPPANTQNFATYREGYNVYGTESV 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	81/396 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	196/378 (52%)
		Lig_chan	532..806	CDD:459656	134/280 (48%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_type1	25..398	CDD:471960	80/395 (20%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	198/384 (52%)