Protein Alignment Ekar and Ir25a

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 966
• Identity: 244/966 - (25%)
• Similarity: 415/966 - (42%)
• Gaps: 232/966 - (24%)

  Fly     6 GFL-LFQFLSYGLGVPPLVRIGAIF----SNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYV 65
            ||| |....|..:.......|..:|    .|:|.....|:...|      :.|::....:|....
  Fly    16 GFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPAAKAVEVVLTY------LKKNIRYGLSVQLDS 74

  Fly    66 EYVNRFDSFETVQKVCKLIRVGVQAVFSP------TDSVLATH-INSICDALDIPNIGRS----- 118
            ...|:.|:...::.:|......::...:|      |.|.:|:. :.|...||.:|.|..|
  Fly    75 IEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKSFTQALGLPTISASYGQQG 139

  Fly   119 -----------AHDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGE 172
                       ...:.:.|.|...::..|...::.::|.|...||:  ::..:..|:. :|....
  Fly   140 DLRQWRDLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAILY--DDSFVMDHKY-KSLLQN 201

  Fly   173 VHMRQV----------SRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYL 227
            :..|.|          .|:..:..|   :..:|:|..|......|.::|:::        |..|
  Fly   202 IQTRHVITAIAKDGKREREEQIEKL---RNLDINNFFILGTLQSIRMVLESV--------KPAY- 254

  Fly   228 FTSFDLETYDLEDFKYNFV---------NITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYL-- 281
                         |:.||.         .|:|.|  |.|.:               :|.||..
  Fly   255 -------------FERNFAWHAITQNEGEISSQR--DNATI---------------MFMKPMAYT 289

  Fly   282 ----NLHIKKSTI-LESEPALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYL 341
                .|.:.::|. |..||.|  .|.:.|.:.|::.     ||:..:.  :..:|...:   .||
  Fly   290 QYRDRLGLLRTTYNLNEEPQL--SSAFYFDLALRSF-----LTIKEML--QSGAWPKDM---EYL 342

  Fly   342 NAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNI----TEP-----SMFFD 397
            |..:::|         |...|..|||    :....|:.|.|.:|..::    |:|     .|.|:
  Fly   343 NCDDFQG---------GNTPQRNLDL----RDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFE 394

  Fly   398 ---------AGS-------------MNVTLVV-----------------ITILETPYVMMHYGKN 423
                     .||             :|..|:|                 .|:::.|::|    ::
  Fly   395 MDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIM----RD 455

  Fly   424 FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSM 488
            .|..:.:.|:|:|::..|:..|.|||.:..|.|.|:|..| |.|:|||:|.:||..:||:.:|||
  Fly   456 ETAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMD-ENGQWNGIVKKLMDKQADIGLGSM 519

  Fly   489 TITYARESVIDFTKPFMNL-GISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIV 552
            ::...||.|||||.|:.:| ||:|:.:.|:| |:.||.|:..|...:|:.:|.|||..|..::|.
  Fly   520 SVMAEREIVIDFTVPYYDLVGITIMMQRPSS-PSSLFKFLTVLETNVWLCILAAYFFTSFLMWIF 583

  Fly   553 GKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLI 617
            .:.||..:: .|....::.....:|:|.:..||.:.:...|.....|:.:|.|::::||..|..|
  Fly   584 DRWSPYSYQ-NNREKYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFI 647

  Fly   618 IVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFF----------------- 665
            |:||||||||||||..|:..|:|:.:|||.|.:|.|..|:..|.||:|
  Fly   648 IIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFYEIWKDL 712

  Fly   666 --RDS---------------VIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQG----NYAFLME 709
              .||               |.:.|.|:|::|...|..|   |.::.:.||...    .:|||.:
  Fly   713 SLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA---TLDEAVARVRNSTAATGFAFLGD 774

  Fly   710 STMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTD 774
            :|.:.|:...:|:|..:|.....|.|.||..:||..:|:.:.|||.|..:..::.|.:||||| |
  Fly   775 ATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKEKWWKN-D 838

  Fly   775 ETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATP 830
            |... |....:.:::.:.:::|||||:|:..||.:|.:...||:|:   |.|...|
  Fly   839 EALA-KCDKPEDQSDGISIQNIGGVFIVIFVGIGMACITLVFEYWW---YRYRKNP 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	77/422 (18%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	135/424 (32%)
		Lig_chan	532..806	CDD:459656	95/311 (31%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	82/456 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	132/407 (32%)