Protein Alignment Ekar and GluRIIC

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Alignment Length: 942
• Identity: 269/942 - (28%)
• Similarity: 465/942 - (49%)
• Gaps: 149/942 - (15%)

  Fly    23 VRIGAIFSNQPGMYNSEL----AFRYAIHRLNMDKSLLPETTVDYY--VEYVNRFDSFETVQK-V 80
            :.|||.|      |:.||    .|...::.:|..:|   |.|:.:|  ::.:...|...|:|: .
  Fly    25 INIGAFF------YDDELELEKEFMTVVNAINGPES---EQTMRFYPLIKRLKPEDGSVTMQEHA 80

  Fly    81 CKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI-------GRSA----HDFSINVYPSKQLVN 134
            |.||..||.|:|.|:....:..:..:|::..||:|       |..|    |..::|:||::.:::
  Fly    81 CDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILS 145

  Fly   135 YAFNDVIQYLNWTRFGILHEKENG-----IINLHQLSRSFHGEVHMRQVSRDSYVSAL-NEFKGK 193
            .|:.|::|...|.:|.|:::.::.     :.:|.||....:..|.:|:..:|.....: ...:|:
  Fly   146 KAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRGE 210

  Fly   194 EIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETY---------DLEDFKYNFVNIT 249
              ..:::|...|.:..||.:..:..:.. :|:::|.: :||||         |.|.|.   ||||
  Fly   211 --RRVVLDCEPNMLVELLNSSTEFGLTG-QYNHIFLT-NLETYTDHLEELAADNETFA---VNIT 268

  Fly   250 SFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILE-SEPA------LMFDSVYVFAI 307
            :.||:...|...              :..||..:..:.:.:.| |:|.      |:.|::.:||.
  Fly   269 AARLLVNPDPPP--------------YSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQ 319

  Fly   308 GLQTLE--QSHSLTLLNISCEEENS----WDGGLSLINYLNAVEWKGLTGP---------IQF-K 356
            ..:...  ....:.:..|:|:...|    |..|..|...:     ||.:|.         :|| :
  Fly   320 SWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLM-----KGTSGVNNTNFRTSILQFDE 379

  Fly   357 DGQRVQFKLDLIKLKQHSIVKVGEWTPHG---HLNI---TEPSMFFDAGSMNVTLVVITILETPY 415
            ||||:.|.:::......  :.:..|.|.|   .||:   .:..|.:.         |.|.:..||
  Fly   380 DGQRITFNIEVYDPLDG--IGIAIWDPRGQITQLNVDVKAQKKMIYR---------VATRIGPPY 433

  Fly   416 VMMHYGK-----NFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQ 475
              ..|.:     |.|||..:.|:.||:::.|:|.|||:|:...|.|::||..|.||.:|||::.:
  Fly   434 --FSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGE 496

  Fly   476 LMKYKADLAVGSMTITYARESVIDFTKPFMNLGISIL-FKVPTSEPTRLFSFMNPLAIEIWIYVL 539
            ::...|.:.:..:|||.||::.:|||.|||.||:||| :|.|..|.| |.:::.|...|:||::|
  Fly   497 IINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKT-LDAYLAPFGGEVWIWIL 560

  Fly   540 IAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMST 604
            |:.|:::....||.::|.::|:..:.|:.:...:.||:.:.::.|.|:.:.|....||.||:...
  Fly   561 ISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQV 625

  Fly   605 RIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSV 669
            |:..:||..|::||..|||||||||||:.:|...|.|.:||::|.::.:||:..|||.....||.
  Fly   626 RMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSN 690

  Fly   670 IETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDT 732
            ...|:..:..|:|..|||:|....:|:.||  |:|:|.||||:|.|:|..:::|:|..:|.....
  Fly   691 ETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGE 755

  Fly   733 KGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIG 797
            |.|.||.|.|:.:|..:|:|||:|.|||::..|..|||||.:.:|..:  ........:..|.:.
  Fly   756 KHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEE--PDPDATPDMTFEELR 818

  Fly   798 GVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRSFWIEI 862
            |:|..|.|||::|.::...||..                  |.|...|| ||      .:|....
  Fly   819 GIFYTLYAGILIAFLIGITEFLV------------------YVQQVALE-ER------LTFKDAF 858

  Fly   863 AEELRYASWCMNKQKRPALTRT--CSKCTIPK 892
            .:|:|:. .|:...::|.:..|  .|..|.|:
  Fly   859 KKEIRFV-LCVWNNRKPIVAGTPISSVRTTPR 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	97/427 (23%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	142/376 (38%)
		Lig_chan	532..806	CDD:459656	99/275 (36%)
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	95/419 (23%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	142/382 (37%)
		Lig_chan	554..827	CDD:459656	99/274 (36%)