Protein Alignment Ekar and Ir21a

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Alignment Length: 759
• Identity: 159/759 - (20%)
• Similarity: 296/759 - (38%)
• Gaps: 162/759 - (21%)

  Fly   129 SKQLVNYAFNDVIQYLNWTRFGI---LHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEF 190
            |::|:|:      ..||...||:   ....||......::..:|.|....|           .|.
  Fly    32 SRRLINH------YQLNKEIFGVGMCDGNNENEFRQKRRIVPTFQGNPRPR-----------GEL 79

  Fly   191 KGKEIH-NIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYD---LEDFKYNFVNITSF 251
            ...:.| |......:|.:..|:..|.|:.:|:......:.|| :|..|   ||:. :..:.||.:
  Fly    80 LASKFHVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSF-VEKSDGLILENL-FKTIPITFY 142

  Fly   252 RLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQT----- 311
            .....||...|.     ..::.||      :.:.|...:..|:| ||...:    :|.||
  Fly   143 HGEINADYEAKN-----KRFTSHI------DCNCKSYILFLSDP-LMTRKI----LGPQTESRVV 191

  Fly   312 -LEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSI 375
             :.:|....|.:....|.:|     :::|.| .:....:..|::.:.......||....|..::.
  Fly   192 LVSRSTQWRLRDFLSSELSS-----NIVNLL-VIGESLMADPMRERPYVLYTHKLYADGLGSNTP 250

  Fly   376 VKVGEW----TPHGHLNITEPSMF--------FDAGSMNVTLVVITILETPYV--MMHYGKNFTG 426
            |.:..|    ....|:|:. ||.|        |...:.|         :.|::  :.....:..|
  Fly   251 VVLTSWIKGALSRPHINLF-PSKFQFGFAGHRFQISAAN---------QPPFIFRIRTLDSSGMG 305

  Fly   427 NERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMV----AQLMKYKADLAVGS 487
            ..|:.|....:|..||:.:.|.  :|:       .:.|......|:|    .|:::...|:.:..
  Fly   306 QLRWDGVEFRLLTMISKRLNFS--IDI-------TETPTRSNTRGVVDTIQEQIIERTVDIGMSG 361

  Fly   488 MTITYARESVIDFTKPFMNLGIS----ILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLC 548
            :.||  :|.::|..   |::|.|    ....:.:....:..:.|.|....:|:.:        :|
  Fly   362 IYIT--QERLMDSA---MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVAL--------IC 413

  Fly   549 IYIVGKLSPIEWKCINACDLENIS--IGNQFSLTDSFWFTIGTFMQ--QSPDIY----PRAMSTR 605
            :|: |.:.||.:     .|...:|  :||...:.:.||:..|.|..  .....|    .|..|||
  Fly   414 VYL-GGIFPIVF-----TDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTR 472

  Fly   606 IISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVI 670
            ::...:..|::||.:.||.::.||:|.....:.:::..||.. .....|||::|...|:|::|..
  Fly   473 LLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLG-LFFRVGTLNNGGWETWFQNSTH 536

  Fly   671 ETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQG---NYAFLMESTMLDYIVQ---RDCNLTQIGGL 729
            ....::::.|:      |..:.::||..|.|.   |||||.....|:|:||   .|.|:::...|
  Fly   537 IPTSRLYKKME------FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSAL 595

  Fly   730 -LDTKGY-----GIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTS----- 783
             |..:.:     |...|:.|.::.||...||..|:.|.|..:      |.:.:...:.:|
  Fly   596 HLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKI------NNEVSWVMQRSSSGRLL 654

  Fly   784 KQSKANS----------LGLESIGGVFVVLIAGIIVAAVVAFFE 817
            :.|.:||          |......|:|:::..|..:.|.....|
  Fly   655 QASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSE 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	55/277 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	89/398 (22%)
		Lig_chan	532..806	CDD:459656	73/308 (24%)
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	22/127 (17%)
		Lig_chan	405..662	CDD:459656	69/283 (24%)