Protein Alignment Ekar and GluRIIE

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Alignment Length: 872
• Identity: 287/872 - (32%)
• Similarity: 449/872 - (51%)
• Gaps: 75/872 - (8%)

  Fly    23 VRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIRVG 87
            |.||.:........|  :.|.:||...|.:..    |::....|.||..|::::..|:|:::..|
  Fly    39 VPIGLLTDQNTEQMN--IVFDHAIDVANQEVG----TSLTSLKEEVNYGDAYQSYGKLCRMLETG 97

  Fly    88 VQAVFSPTDSVLATHINSICDALDIPNI----GRSAHDFSINVYPSKQLVNYAFNDVIQYLNWTR 148
            :..||.|:....|.|:.|||||:|||:|    ..:|..|:::.:|:.  :..|...:|...||||
  Fly    98 IAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPHPAD--LAKALYSLITEFNWTR 160

  Fly   149 FGILHEKENGIINLHQLSRSFHGEVHMRQVSR------DSYVSALNEFKGKEIHNIIIDTNSNGI 207
            |..|:|....:..|::|:........:..|.|      .:|...|...: |.:.|.|:...|:..
  Fly   161 FIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVR-KSVDNRIVVVGSSET 224

  Fly   208 SILLKNILQQQ--MNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGL 270
            .....|..||.  :|| .|.|:..:.|..::|||::||:..|||..||.....:.||::|..:|
  Fly   225 MPEFLNQAQQVGIINE-DYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLG- 287

  Fly   271 YSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTL-LNISCEEENSWDGG 334
              :...:..:.|    .|..:..|.||.:|:|.:||   |||:......: .|.|...|:..|.|
  Fly   288 --YPTDQDEFRN----GSCPITVEMALTYDAVQLFA---QTLKNLPFKPMPQNCSQRTESVRDDG 343

  Fly   335 LSLINYLNAVEW--KGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEW------TPHGHLNITE 391
            .|..||:..:..  :.|||||.|:...|..:.||:|:|:...|||||.|      .|......|.
  Fly   344 SSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTA 408

  Fly   392 PSMFFDAGSMNVT-LVVITILETPYV-MMHYGKNFTGNERFYGFCVDILETISREVGFDYILDLV 454
            .....|....|.| ::::::...||. ::...|...||.::.|:.||:::.::.::||::.. :.
  Fly   409 QFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF-VN 472

  Fly   455 PDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSE 519
            ....||:.:..|.|..||:.::|..:||||:..:|||..||..:|||.|||||||:||:..|...
  Fly   473 GGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKA 537

  Fly   520 PTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFW 584
            ...||:||:|.:.|:|.::..::..|||..:|:|:|||.||.....|..|...:.|||:|.:|.|
  Fly   538 TPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIW 602

  Fly   585 FTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQT 649
            ||.|..:||..:|.|:|:|||.::|.|.||:||:|:|||||||||||.|:..:.|.:.:|||...
  Fly   603 FTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK 667

  Fly   650 E-ISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQG-NYAFLMESTM 712
            : :.||...:|||..||..|..|.|||:.:.| ::.|...|....:|:.||... :||||||||.
  Fly   668 DGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRVKTNTHYAFLMESTS 731

  Fly   713 LDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDE-T 776
            ::|..:|:|||.:||..||.||||||..|..|.|.|.:.|:|||||:|.::.:.:|||..... .
  Fly   732 IEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGI 796

  Fly   777 CTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQ 841
            |..|..:..  |..|.:.::.|||.||:.|...|.:..... |..|
  Fly   797 CATKEDAPD--ATPLDMNNLEGVFFVLLVGSCCALLYGIIS-WVLF------------------- 839

  Fly   842 DGILESERNYTPPDRSFWIEIAEELRY 868
              :::...:|..|.|.   .:.||.::
  Fly   840 --VMKKAHHYRVPLRD---ALKEEFQF 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	111/386 (29%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	154/372 (41%)
		Lig_chan	532..806	CDD:459656	118/276 (43%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	111/381 (29%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	154/372 (41%)
		Lig_chan	551..824	CDD:459656	118/275 (43%)