Protein Alignment Ekar and Grin2a

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_036705.3
• Gene: Grin2a / 24409
• RGDID: 2737
• Length: 1464
• Species: Rattus norvegicus
• Alignment Length: 926
• Identity: 208/926 - (22%)
• Similarity: 382/926 - (41%)
• Gaps: 192/926 - (20%)

  Fly    20 PPLVRIGAIFSNQPGMYNSELAFRYAIHR---LNMDKSLLPETTVDYYVEYVNRFDSFETVQKVC 81
            ||.:.|..:..:...:...||...:...:   |.:|        |:.....:||.|....:..||
  Rat    31 PPALNIAVLLGHSHDVTERELRNLWGPEQATGLPLD--------VNVVALLMNRTDPKSLITHVC 87

  Fly    82 KLI---RVGVQAVFSPTD-SVLATHINSICDALDIPNIG-------------------------- 116
            .|:   |:........|| ..:|..::.|.....||.:|
  Rat    88 DLMSGARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQ 152

  Fly   117 -------RSAHDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVH 174
                   :...|:..:|:.....:...:.|.|.::..|                 :..||.|...
  Rat   153 QQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTT-----------------VDNSFVGWDM 200

  Fly   175 MRQVSRD-SYVSALNEFKGKEIHN--IIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETY 236
            ...::.| |:..|..:.:.|:||:  |::..:.:...::|.......:..|.:.::..|......
  Rat   201 QNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNT 265

  Fly   237 DL--EDFKYNFVNITSFRLVDTADVGVKQILKD-IGLYSHHIFKKPYLNLHIKKSTILESEPALM 298
            :|  ::|....::::    .|..|..::..::| :|:.:      ...:..::|.:.:....|..
  Rat   266 ELIPKEFPSGLISVS----YDDWDYSLEARVRDGLGILT------TAASSMLEKFSYIPEAKASC 320

  Fly   299 FDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQF 363
            :.........|.||.|    .::|:      :|||             |.|:..   ::|.:|..
  Rat   321 YGQAEKPETPLHTLHQ----FMVNV------TWDG-------------KDLSFT---EEGYQVHP 359

  Fly   364 KLDLIKL-KQHSIVKVGEWTPH----GHLNITEPSMFFDAGSMNVTLVVITILETPYVMMH---- 419
            :|.:|.| |.....|||:|...    .|........|.|....:..|.::|:.|.|:|::.
  Rat   360 RLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDP 424

  Fly   420 --------------YGK-NFTGNERF------YGFCVDILETISREVGFDYILDLVPDRKYGAKD 463
                          :.| |.:.||..      .|||:|||:.:||.|.|.|.|.||.:.|:|.|
  Rat   425 LTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK- 488

  Fly   464 PETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVP--TSEPTRLFSF 526
             ....||||:.:::..:|.:||||:||...|..|:||:.||:..|||::....  |..|:   :|
  Rat   489 -VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS---AF 549

  Fly   527 MNPLAIEIWIYVLIAYFLVS-LCIYIVGKLSPIEWKCINACDLENISIGN-----QFSLTDSFWF 585
            :.|.:..:|:.:.:...:|| :.:::....||:.:.       .|::.|.     .|::..:.|.
  Rat   550 LEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYN-------RNLAKGKAPHGPSFTIGKAIWL 607

  Fly   586 TIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQT 649
            ..| .|....|...|:..:::|:.|.|.||::|.:||||||||||:..|..::.:....|...|.
  Rat   608 LWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQR 672

  Fly   650 EISY------GTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNY-AFL 707
            ...|      ||:.:|||....|::.  .|...:.:..|::      ..||.:..:..|.. ||:
  Rat   673 PHDYSPPFRFGTVPNGSTERNIRNNY--PYMHQYMTRFNQR------GVEDALVSLKTGKLDAFI 729

  Fly   708 MESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDK 768
            .::.:|:|...||  |.|..||.  :..|.|||||..|||||:.:|.||:|:....|:::.|...
  Rat   730 YDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETL 794

  Fly   769 WWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFE--FWYNFRYNYEATPS 831
            |.     |....|...:..::.|.::::.|||.:|.|.:.::.:...:|  |::..|:.:....|
  Rat   795 WL-----TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCS 854

  Fly   832 QSVVNNKYNQDGILES 847
                    ::.|:|.|
  Rat   855 --------DRPGLLFS 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	67/416 (16%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	122/413 (30%)
		Lig_chan	532..806	CDD:459656	79/291 (27%)
Grin2a	NP_036705.3	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	67/415 (16%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	123/423 (29%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1	599..620		5/20 (25%)
		NMDAR2_C	839..1464	CDD:463148	6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1083
		PDZ-binding. /evidence=ECO:0000305	1462..1464