Protein Alignment Ekar and Grik5

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_006228444.1
• Gene: Grik5 / 24407
• RGDID: 2735
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 915
• Identity: 336/915 - (36%)
• Similarity: 503/915 - (54%)
• Gaps: 98/915 - (10%)

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRF 71
            |:..|.:....|...:|:.||..:|......| ||...|..::|....:..:..|:..:..:.|.
  Rat     9 LIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRD 73

  Fly    72 DSFETVQKVCKLIRVGVQAVFSPTDS-VLATHINSICDALDIPNIGRSAHD---------FSINV 126
            ..:||...:|:::..||.:|..|:.| ..|:.::.||...:||:|.....:         .|:::
  Rat    74 SQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSL 138

  Fly   127 YPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSA 186
            |||.:.|:.|.:.:::..|:....::..|...::.|.:|.|.|     ...|.|...|||. ...
  Rat   139 YPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDP-TPL 202

  Fly   187 LNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSF 251
            |.|.:..::..||||.|::...::|:...:..|....|.|:.|:.|.....|:....:..||..|
  Rat   203 LKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGF 267

  Fly   252 RLVDTADVGVKQILKDIGLYSHHIFKKPY---LNLHIKKSTILESEP------ALMFDSVYVFAI 307
            .:.:|:                |.|...:   ||:..:::....:.|      |||||:|:|...
  Rat   268 SMFNTS----------------HPFYPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVS 316

  Fly   308 GLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLK 371
            .::.|.:|..:.:..::|...|.|..|.||:|||..||:.||||.::|.. |||..:.|.:::..
  Rat   317 AVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS 381

  Fly   372 QHSIVKVGEWTPHGHL--NITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNF---TGNERFY 431
            :....::|.|..:..|  |.|...:.......|.||||.||||.||||..  .||   :|||||.
  Rat   382 RQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRR--PNFQALSGNERFE 444

  Fly   432 GFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLM-KYKADLAVGSMTITYARE 495
            |||||:|..::..:.|.|.|.||.|..|||.:| .|.|.|||.:|: :.||||||.:.|||..||
  Rat   445 GFCVDMLRELAELLRFRYRLRLVEDGLYGAPEP-NGSWTGMVGELINRQKADLAVAAFTITAERE 508

  Fly   496 SVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW 560
            .||||:||||.||||||::|........|||::|.:..:|:::|:||..||..:::..:|||.||
  Rat   509 KVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW 573

  Fly   561 ----KCINACD--LENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIV 619
                .|:.|..  ||     ||::|.:|.||.:|.||||..:|.|||:|||.:|..|..|:|||:
  Rat   574 YNPHPCLRARPHILE-----NQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIII 633

  Fly   620 ASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKK 684
            :|||||||||||.:||..|:|:|:|||.||.|.|||:.:|||||||::|..:||:::|..|.:|:
  Rat   634 SSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQ 698

  Fly   685 PSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKI 749
            ||.|..:.|:||.||....||||:||||.:|..:.:|||||||||||||||||..|.|||:||:|
  Rat   699 PSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEI 763

  Fly   750 SLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVA 814
            :||||:|||...:::|..|||:.  ..|.::   :..:|..||:|:|||:|||||.|:|:|..||
  Rat   764 TLAILQLQENNRLEILKRKWWEG--GRCPKE---EDHRAKGLGMENIGGIFVVLICGLIIAVFVA 823

  Fly   815 FFEFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRYASWC-----MN 874
            ..||.::.|.:.|   |:.|                      |...|:.:|||:|..|     ..
  Rat   824 VMEFIWSTRRSAE---SEEV----------------------SVCQEMLQELRHAVSCRKTSRSR 863

  Fly   875 KQKRP 879
            :::||
  Rat   864 RRRRP 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	98/393 (25%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	200/378 (53%)
		Lig_chan	532..806	CDD:459656	142/279 (51%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	97/394 (25%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	200/378 (53%)