Protein Alignment Ekar and nmr-2

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001256640.1
• Gene: nmr-2 / 180002
• WormBaseID: WBGene00003775
• Length: 990
• Species: Caenorhabditis elegans
• Alignment Length: 903
• Identity: 222/903 - (24%)
• Similarity: 362/903 - (40%)
• Gaps: 196/903 - (21%)

  Fly    64 YVEYVNRFDSF-----ETVQK------VCKLIRVGVQAVFSPTDSVLATH-------INSICDAL 110
            |..|..|..|:     |.::|      |..|.|:..:..|...|.:|.|.       ::.:|:.:
 Worm    48 YQHYAGRSKSYDKAFKEVIRKINDATAVSSLRRLATRYNFQAVDCILPTGTFFVKEVLDCLCNNV 112

  Fly   111 DIPNIGRSAHDFSINVYPSKQLVNYAFNDVIQY-----LNWT--RFGILHEKENG---IINL--- 162
            ...|:.......:...|.|.......|.....|     :.|.  ..|...|.:.|   ||.:
 Worm   113 TSNNVALIIFVTASETYDSTTAAEQYFLTAASYTGIPIIAWNADNAGFTFENDLGPYRIIQMAPP 177

  Fly   163 --HQ------LSRSFH----GEVHMRQVSRDSYVSALNE----FKGKE-----IHNIIIDT-NSN 205
              ||      |.|.::    |.|.......|.:|:|:.|    |..|.     ||...::| |..
 Worm   178 IEHQARAMLALLRRYNWPKFGVVTSEMAGNDRFVTAIREELELFSNKSTKFEMIHFSHMNTKNDT 242

  Fly   206 GISILLKNILQQQMNEYKYHYLF-------TSFD-LETYDLEDFKYNFVNITSFRLVDT-----A 257
            .:.:.|.::   :.|:.|...|:       |.|. .|..|:...||.::...|.:...|     |
 Worm   243 DVDLKLADV---KKNQAKIILLYANAAQAGTIFSHAEKMDMIGEKYLWIGTQSVKGTQTTVKAPA 304

  Fly   258 DVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESE----PALMFDSVYVFAIGLQTLEQSHSL 318
            ..|:..:                 |.|...:.:....    |.::..:..:|...|..|..:...
 Worm   305 QAGMLCV-----------------NFHTVSNAMFAPRDDILPLIIQLAPKLFGAALLQLRPNEMF 352

  Fly   319 TL-LNISCEEENS---WDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFK------------LDL 367
            :| .|:||:.|:.   ||.|..:..::.|...||  .|....||....|.            |.:
 Worm   353 SLKSNVSCKSEDGDPYWDNGKYIYEHMKAAFVKG--NPFHVDDGHDSFFYTFEKTGRLRNSILQI 415

  Fly   368 IKLKQHS-----IVKVGEWTPHGHLNITE----------PSMFFDAGSMNVTLVVITILETPYV- 416
            ..|:.:|     ..|||.:| :..|.:.:          |....|    ...:.|:|:.|.|::
 Worm   416 SNLRTNSKGEKTWEKVGIFT-NNELKMADVQWPGEKANPPQGAAD----KFHVKVVTLHEPPFIA 475

  Fly   417 -----------------MMHYG-----------KNFTGNERFYGFCVDILETISREVGFDYILDL 453
                             :..:|           ||.|..:...|:|||:|..::.::||.|.|..
 Worm   476 VSDVDPDTQKCPGNQGSICDWGDVEYTDGAGVKKNRTLLKCCSGYCVDLLNKLANDIGFTYTLYK 540

  Fly   454 VPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTS 518
            |.|.|:|.| .|.| |||::|.||..|||:.|.|:.:...|...|||:.||::.||||:.|:.:.
 Worm   541 VRDEKWGLK-TENG-WNGLIADLMHNKADMCVTSLKLNSERARDIDFSLPFLDTGISIIVKIRSG 603

  Fly   519 --EPTRLFSFMNPLAIEIWIYVL-IAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLT 580
              .||   :|:.|.....|:.:| :...:.::.|::...:||..:........|     ::|||.
 Worm   604 VLSPT---AFLEPFEYSTWVIILFVCIHVAAISIFLFEWVSPYSFNMQKYPPPE-----HKFSLF 660

  Fly   581 DSFWFTIGTFMQQ--SPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAE 643
            .|:|....|....  |.|: |::..:|:::..|..|.|..:|.||||||||:.|......:....
 Worm   661 RSYWLVWATLFSASVSTDV-PKSTVSRLMALVWAAFGLTFLAVYTANLAAFMITRVQYYDLSGIH 724

  Fly   644 DLA------SQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDN--KKPSAFTTTYEDGIKRV- 699
            |..      .:....:||:|.|:|.        ||.|:.|..|..  |....|......||:.|
 Worm   725 DPMLNFPHDQKPPFRFGTVDGGNTH--------ETMKRNWHKMHEYVKHNKYFRMNISAGIEAVK 781

  Fly   700 NQGNYAFLMESTMLDYIVQRD--CNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDI 762
            |:...||:.::.:|||...:|  |.|..:|......||||..||.||....::..:|:.|::||:
 Worm   782 NEELDAFIYDAVVLDYWAGKDANCALMTVGKWASMTGYGIGFPKNSPHTSLVNHYMLQYQQKGDL 846

  Fly   763 QMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWY 820
            :.|.:.|...   .|| .::..|:::..||:|:....||:|..||||:.:|..||..|
 Worm   847 ERLQNFWLTG---ACT-PDSHSQTQSAPLGIENFLSAFVLLAGGIIVSVIVLGFEHIY 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	84/416 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	119/413 (29%)
		Lig_chan	532..806	CDD:459656	78/287 (27%)
nmr-2	NP_001256640.1	Periplasmic_Binding_Protein_type1	102..443	CDD:471960	71/363 (20%)
		Periplasmic_Binding_Protein_Type_2	460..860	CDD:473866	121/422 (29%)