Protein Alignment Ekar and nmr-1

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_495033.2
• Gene: nmr-1 / 173929
• WormBaseID: WBGene00003774
• Length: 1025
• Species: Caenorhabditis elegans
• Alignment Length: 1034
• Identity: 224/1034 - (21%)
• Similarity: 387/1034 - (37%)
• Gaps: 299/1034 - (28%)

  Fly    60 TVDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRSAHDFSI 124
            |:||.|..:   ...|..|:..|.::|.|.|.|.......:.|:.:  |.:....:...:.|..:
 Worm    18 TIDYKVSVL---IVSEPNQETFKELKVSVTAAFVEVFGSTSYHLGN--DTISAAFVDAKSGDNRL 77

  Fly   125 NVYPS---KQLVNYAFNDVI---QYLNWTRF-------------------GIL-----HEKEN-- 157
            .:...   .|::|::...||   ...:.:||                   |::     ..|:|
 Worm    78 ELTQDIVCSQMLNHSLASVIFSPLLTSSSRFIDLVTSSAYTLSFYKLPVVGVMVRDAEFSKKNIY 142

  Fly   158 -------------GIINLHQLSRSFHGEVHMRQVSRDSYVSA---LNEFKGKEIHNIIIDTNSNG 206
                         ..:.||.|....:.:|.:..|.||  ::|   :.||:.:.:.
 Worm   143 PTFVRPTAPLSDEAFVFLHMLLSLKYRQVVVLSVKRD--INADQFVEEFEKRRVE---------- 195

  Fly   207 ISILLKNILQQQMNEYKYHYLFTSFDLETYDL-------EDFKYNFVNITSFRLVDTADVGVKQI 264
            ..|:::..::.::||.....|..||:..|.::       :|....|.|..     |....|...|
 Worm   196 FKIIVQRYIEVELNENLNDTLAESFEEVTSNIIVLFAKKDDAVRIFANAG-----DLTGKGKVWI 255

  Fly   265 LKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLL-NISCEEE 328
            :.:....:|::   |..:|..:   :.::..:::.||..:....::|:.:...:.:. .:.|:.:
 Worm   256 VSESAGEAHNV---PNGSLGCR---LGQTAFSVLRDSFSILKSAMETIFRESKIDIFPPVECDRD 314

  Fly   329 NSWDGGLSLINYLNAVEWKGLTGP-------------IQFKDG-QRVQFKLDLI----------- 368
             |.|           .||..|..|             :.|.|. :|:..:.|:|
 Worm   315 -SVD-----------AEWNSLQAPALLNEICGTSTSRVHFNDKCERIGVEYDIINFHMERKQVGN 367

  Fly   369 ------KLKQHSIVKVGEWTPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNFT-- 425
                  :|.:.||...|...|   |.|:.|.          .|.|:|:.:.|:|       :|
 Worm   368 MVGDILRLDEDSIEWAGGTKP---LEISLPK----------HLRVVTVADPPFV-------YTTP 412

  Fly   426 ----------GN----------------------------ERF--YGFCVDILETISR------- 443
                      ||                            |.|  .|..:|:|..:|.
 Worm   413 IGSPSQCAELGNTVVEWSIFDKIVVSGPWYSCPLTLENSTEYFCCAGLAIDLLSNLSLPEANNSI 477

  Fly   444 EVGFDYILDLVPDRKYGA--KDPETG-EWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFM 505
            :..|.:.|.|  :..||.  ....|| ..:|::.:|....||:|:|.:||...||.::|||:|::
 Worm   478 DTSFTFSLHL--NESYGVVQASETTGITISGVIGELDGDTADMAIGGITINPERERIVDFTEPWL 540

  Fly   506 NLGISILFK-VPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIE---------- 559
            ..||.||.| :|...|.:  ||:.||...:|..:.|:..||.|.||.:...||.|
 Worm   541 YHGIRILEKNIPRDSPMQ--SFLQPLQSSLWTALFISVILVGLAIYCLDFKSPFERFYQADKEME 603

  Fly   560 ---------WKCINACDLENISIGNQFSLTDSFWFTIGTFMQQS-PDIYPRAMSTRIISSTWGFF 614
                     |  |.....||::.|      ::.||..|..:... .:..||:.|.|::...|..|
 Worm   604 QDLKKEFELW--IGKDADENVNFG------EAMWFVWGVLLNSGVSEKTPRSCSARVLGIVWCGF 660

  Fly   615 SLIIVASYTANLAAFL------------TTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRD 667
            .:|:||||||||||||            |..|:.||..|         .|:||:.:.:...:|:.
 Worm   661 CMIMVASYTANLAAFLVLDQPEKGLTGVTDPRLRNPSAN---------FSFGTVLNSNVYQYFKR 716

  Fly   668 SVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDT 732
            .|  ....::|.|:   |.......|.....:|....||:.:||.|::...|.|.|...|.|...
 Worm   717 HV--ELSSMFRKME---PHNVRRASEAVHSLLNGSLDAFIWDSTRLEFEAARHCELRTRGSLFGR 776

  Fly   733 KGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIG 797
            ..|||...|.|||...|:.|||.:.|.|.::.|..||.......|..:  :.:|.|. |||.::.
 Worm   777 SAYGIGLQKNSPWTPHITSAILRMSESGVMEKLDQKWIDRGGPNCVVE--AHKSPAR-LGLVNMK 838

  Fly   798 GVFVVLIAGIIVAAVVAF----------------------FEFWYNFRYNYEATPSQSVVNNKYN 840
            .:|:::.:|:.:...::|                      |:.|::.....:..|.:.    |||
 Worm   839 DIFILVSSGVALGIFLSFVEVSYGRRLADKGRRRRIVTRYFQKWHDLTLGKKRRPYRL----KYN 899

  Fly   841 QDGILESERNYTPPDRSFWIEIAE--ELR---------YASWCMNKQKRPALTRTCSKC 888
            .|.:: ..|.::..:|..:.|:.|  ::|         |..|.....|...|...||:|
 Worm   900 LDRMI-VRRGFSGLERCSFQELRERRQIRGLPTSKVDPYCFWPDLDFKDKPLVLFCSRC 957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	70/416 (17%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	124/453 (27%)
		Lig_chan	532..806	CDD:459656	85/305 (28%)
nmr-1	NP_495033.2	Periplasmic_Binding_Protein_type1	19..384	CDD:471960	66/404 (16%)
		PBP2_iGluR_NMDA_Nr1	394..822	CDD:270437	125/470 (27%)
		Lig_chan	566..844	CDD:459656	85/302 (28%)
		LITAF	949..1017	CDD:197841	4/9 (44%)