Protein Alignment Ekar and glr-3

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_492017.3
• Gene: glr-3 / 172449
• WormBaseID: WBGene00001614
• Length: 836
• Species: Caenorhabditis elegans
• Alignment Length: 854
• Identity: 287/854 - (33%)
• Similarity: 442/854 - (51%)
• Gaps: 112/854 - (13%)

  Fly    47 HRLNMDKSLLPETT-----VDYYVEYVN---------RFDSFETVQ--------KVCKLIRVGVQ 89
            :::.:..:|:.|..     ||:.|:.:.         :.:||:.|.        .||..:.:|..
 Worm    20 YKIAIPANLIDEVNPVLEFVDFRVQVIPYETKPLWRIKQESFKIVGISIENGLFSVCNCLILGAS 84

  Fly    90 AVFSPT--DSVLATH--INSICDALDIPNIGRSAH-----DFSINVYP---SKQLVNYAFNDVIQ 142
            |:..|.  |..||..  :.||.|..::|.:  |.|     ..|.:::|   :|.|...||   |:
 Worm    85 AIILPEQYDGHLAAAAIVQSIADNTNVPCV--SLHLSPPTRPSTHLHPHLNAKSLAVAAF---IK 144

  Fly   143 YLNWTRFGILHEKENGIINL---------------HQLSRSFHGEVHMRQVSRDSYVSALNEFKG 192
            ...|....::.|:.:.::.:               .||.|..||         |.|.:.|...|.
 Worm   145 REKWKDVVVVFEEPDELLEITDMITAGHFDPDSFSSQLVRLKHG---------DDYGNELKHIKN 200

  Fly   193 K-EIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFK-YNFVNITSFRLVD 255
            | :.:.|:|:.........|:......|....|||:....||.|.|::..: ....|||||.:.|
 Worm   201 KLDRYRIVINIPLQKALHFLEQAANMSMCGVLYHYVVMDMDLVTVDIDSIRGIEDCNITSFGVHD 265

  Fly   256 TADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLE-QSHSLT 319
            .....::.|.::|                :.||:|...:..:    .|..:|.:.||. ...|:.
 Worm   266 VNSEYIEDIRQEI----------------VHKSSIRLPKKGV----PYTTSIWIDTLRLLIRSMK 310

  Fly   320 LLNISCEEE--NSWDGGLSLINYLNAVEWKGLTGPIQF-KDGQRVQFKLDLIKLKQHSIVKVGEW 381
            .:.|..|..  :||..|..:..........|::|.:.: ..|:|..:.|.:.: :..|..|..||
 Worm   311 SIQIWDEPRCGSSWKSGSDIKKRFFENPLAGISGDLHWAPSGERSNYTLHVYR-RTLSFQKFAEW 374

  Fly   382 TPHGHLNITEPSMFFDAGSMNVT-----LVVITILETPYVMMHYGKNFTGNERFYGFCVDILETI 441
            :.......:..::.....|..:|     |.:...||.|:||:      |.|..:.|:|:|:|..|
 Worm   375 SSRTRRIASSEAVVIANSSEKLTLEGKHLKISVYLEAPFVMI------TSNGSYEGYCIDLLHKI 433

  Fly   442 SREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMN 506
            :..:.|.|.:..|.|..||:|: ..|:|:|||.:|.:..|||||.|:||:|.|..|||||.|:|:
 Worm   434 ANILKFTYTIQKVRDNAYGSKE-SNGKWSGMVGELQRGDADLAVASLTISYGRSEVIDFTVPYMH 497

  Fly   507 LGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENI 571
            ||||||||.|....:..|.||:||:.::||....:||:||:.|:|:.|:||.|....:..:.:..
 Worm   498 LGISILFKKPRIRDSDWFKFMDPLSTQVWIMTFASYFVVSVAIWIIAKISPYEQFERDEDNGQYK 562

  Fly   572 SIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMI 636
            .:.|||||.:|||||:.:.|||..::.|||.|||:::..|.||:||:::||||||||.|||.||.
 Worm   563 PVDNQFSLRNSFWFTVCSLMQQGSELCPRAASTRLLTGIWWFFALILISSYTANLAAVLTTRRME 627

  Fly   637 NPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQ 701
            .|||||:|||:||:|.||||..||||:||.:|.||||:::|:.| :..|..|..:.::||.||..
 Worm   628 TPIENADDLAAQTKIKYGTLGRGSTMSFFNESKIETYERMWQLM-SSSPGLFVQSSKEGIARVKS 691

  Fly   702 GNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLY 766
            .:||:||||:||:|.|:|||.|.|||||:|.|||||..|||||:|:.||.|||.|||:.::..|.
 Worm   692 SDYAYLMESSMLEYAVERDCELMQIGGLIDQKGYGIGLPKGSPYRELISTAILRLQEKTELTELK 756

  Fly   767 DKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPS 831
            :||||:....|.:.....|...     |||||:|::|:.|:::.||:..||    .....:.:|:
 Worm   757 EKWWKDKSVVCEQPKRKDQDDG-----ESIGGIFIILVVGLVLTAVLVIFE----LITTRKPSPA 812

  Fly   832 QSVVNNKYN 840
            ||.|....|
 Worm   813 QSQVIRHVN 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	82/397 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	183/373 (49%)
		Lig_chan	532..806	CDD:459656	136/273 (50%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	82/398 (21%)
		Periplasmic_Binding_Protein_Type_2	401..761	CDD:473866	182/367 (50%)