Protein Alignment Ekar and Grin3b

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 677
• Identity: 162/677 - (23%)
• Similarity: 285/677 - (42%)
• Gaps: 141/677 - (20%)

  Fly   296 ALMFDSVYVFAIGLQTLEQSH---SLTLLNISCEE---ENSWDGGLSLINYLNAVEWKGLTGPIQ 354
            |::.|.|.:.|..|.::...|   :|....::|::   ..|...|.:|..:|....::|.||.:.
  Rat   291 AVVHDMVELVAQALSSMALVHPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAVW 355

  Fly   355 FKDGQRV----QFKLDLIK---LKQHSIVKVGEWTPHGHLNITEPSMFFDAGSMNV--------- 403
            .....:|    .||:..::   |...:...||.| ..|.|:. :|.    |.::.|
  Rat   356 VTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSW-QDGQLDF-QPG----AAALRVPSPSGTQAR 414

  Fly   404 -TLVVITILETPYVM----------------MHYGKN------------------FTGNERFYGF 433
             .|.|:|::|.|:|.                :..|.|                  .|.....||:
  Rat   415 PKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGY 479

  Fly   434 CVDILETISREVGFDYILDLVPDRKYGA-KDPETGEWNGMVAQLMKYKADLAVGSMTITYARESV 497
            |:|:||.::.::.||:.|.:|.|.|||| :|   |.|.|:|..|:..:|.:||.|.:|..||..|
  Rat   480 CIDLLERLAEDLAFDFELYIVGDGKYGALRD---GRWTGLVGDLLAGRAHMAVTSFSINSARSQV 541

  Fly   498 IDFTKPFMNLGISILFKV-PTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWK 561
            :|||.||.:..:.|:.:. .|:.|  :.:||.||...:|:.|..|..|.:|.      |:..||:
  Rat   542 VDFTSPFFSTSLGIMVRTRDTASP--IGAFMWPLHWSMWVGVFAALHLTALF------LTLYEWR 598

  Fly   562 CINACDLENISIGNQFSLTDS----FWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASY 622
            ..........:.|..||.:.:    :....|..:....   |:..:.|.:.:.|..|.|::::||
  Rat   599 SPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKT---PKCPTGRFLMNLWAIFCLLVLSSY 660

  Fly   623 TANLAAFLTTERMINPIENAED--LASQTE-ISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKK 684
            ||||||.:..::....:....|  |...:: ..:||:...|...:.:.|..|.:..:      ::
  Rat   661 TANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHM------RR 719

  Fly   685 PSAFTTTYEDGI-------KRVNQGNYAFLMESTMLDY--IVQRDCNLTQIGGLLDTKGYGIATP 740
            .||.||.:  |:       .::|    ||:|:.::|||  .:..||.|..:|.....:||||..|
  Rat   720 HSAPTTPH--GVAMLTSDPPKLN----AFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLP 778

  Fly   741 KGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIA 805
            :.||....:|..|...:..|.|.:|:|||:|..  .| .|.....::...:|:....|:||:|..
  Rat   779 QNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMV--PC-GKRVFAVTETLQMGVYHFSGLFVLLCL 840

  Fly   806 GIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRYAS 870
            |:..|.:.:..|..:     |.....:....||.                 .:|:..::::..|
  Rat   841 GLGSALLTSLGEHVF-----YRLVLPRIRRGNKL-----------------QYWLHTSQKIHRA- 882

  Fly   871 WCMN------KQKRPALTRTCSKCTIP 891
              :|      :|:|....|:..|..:|
  Rat   883 --LNTGPPEGQQERAEQERSGPKDELP 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	24/106 (23%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	114/430 (27%)
		Lig_chan	532..806	CDD:459656	71/289 (25%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	19..401	CDD:380600	25/115 (22%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	112/419 (27%)
		Lig_chan	574..841	CDD:459656	71/290 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910		7/29 (24%)
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250|UniProtKB:Q91ZU9	951..984