Protein Alignment Ekar and Grin1

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001359487.1
• Gene: Grin1 / 14810
• MGIID: 95819
• Length: 959
• Species: Mus musculus
• Alignment Length: 907
• Identity: 225/907 - (24%)
• Similarity: 383/907 - (42%)
• Gaps: 178/907 - (19%)

  Fly    20 PPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMD----KSLLPETTVDYYVEYVNRFDSFETVQKV 80
            |.:|.|||:.|.:    ..|..||.|:::.|..    |..|..|:|      .::.::.:....|
Mouse    24 PKIVNIGAVLSTR----KHEQMFREAVNQANKRHGSWKIQLNATSV------THKPNAIQMALSV 78

  Fly    81 CK-LIRVGVQAVF-----SPTDSVLATHINSICDALDIPNIG----------RSAHDFSINVYPS 129
            |: ||...|.|:.     :|.|....|.::.......||.:|          :|.|...:...|.
Mouse    79 CEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPP 143

  Fly   130 KQLVNYAFNDVIQYLNWTRFGIL----HE-------------------KENGIINLHQLS----R 167
            ....:..:.::::..||....:|    ||                   |:....||.|||    |
Mouse   144 YSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYDNKR 208

  Fly   168 SFHGEVHMRQVSRDSYVSA-LNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSF 231
            ....|..::.......|:| |.|.:..|...||:..:.:..:.:.:......|....|.:|....
Mouse   209 GPKAEKVLQFDPGTKNVTALLMEARDLEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGER 273

  Fly   232 DLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPA 296
            ::....|   :|....|...:|::.                                   ::|.|
Mouse   274 EISGNAL---RYAPDGIIGLQLING-----------------------------------KNESA 300

  Fly   297 LMFDSVYVFAIGLQTLEQSHSLTLLNISC-EEENSWDGGLSLINYLNAVEW-KGLTGPIQF-KDG 358
            .:.|:|.|.|..:..|.:..::|.....| ...|.|..|......|.:.:: .|:||.::| :||
Mouse   301 HISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDG 365

  Fly   359 QRVQFKLDLIKLKQHSIVKVGEWTPHG-HLNITEPSMFFDAG--------SMNVTLVVITILETP 414
            .|......::.|:...:|:||.:  :| |:...:..:.:..|        .|:..|.::||.:.|
Mouse   366 DRKFANYSIMNLQNRKLVQVGIY--NGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEP 428

  Fly   415 YV------------------------MMHYGKNFT--GNERF------YGFCVDILETISREVGF 447
            :|                        ::..|.|.|  |:.|.      ||||||:|..::|.:.|
Mouse   429 FVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCVDLLIKLARTMNF 493

  Fly   448 DYILDLVPDRKYGAKD----PETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLG 508
            .|.:.||.|.|:|.::    ....|||||:.:|:..:||:.|..:||...|...|:|:|||...|
Mouse   494 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQG 558

  Fly   509 ISILFK--VPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENI 571
            ::||.|  :|.|   .|.|||.|....:|:.|.::..:|::.:|::.:.||.....:|:.:.|.
Mouse   559 LTILVKKEIPRS---TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEE- 619

  Fly   572 SIGNQFSLTDSFWFTIGTFMQQS-PDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERM 635
               :..:|:.:.||:.|..:... .:..||:.|.||:...|..|::||||||||||||||..:|.
Mouse   620 ---DALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 681

  Fly   636 INPIENAED--LASQTE-ISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYE---D 694
            ...|....|  |.:.:: ..|.|:...|...:||..|  ....::|.|:..       .||   :
Mouse   682 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQV--ELSTMYRHMEKH-------NYESAAE 737

  Fly   695 GIKRVNQGN-YAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQE 758
            .|:.|.... :||:.:|.:|::...:.|:|...|.|....|:||...|.|||:..:||:||:..|
Mouse   738 AIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHE 802

  Fly   759 RGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWY 820
            .|.::.| ||.|....|..:|.|...     :|..|::.|||:::..||:....:.|.|..|
Mouse   803 NGFMEDL-DKTWVRYQECDSRSNAPA-----TLTFENMAGVFMLVAGGIVAGIFLIFIEIAY 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	81/417 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	126/414 (30%)
		Lig_chan	532..806	CDD:459656	82/281 (29%)
Grin1	NP_001359487.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	82/428 (19%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	128/420 (30%)
		CaM_bdg_C0	856..884	CDD:402271	1/3 (33%)