Protein Alignment Ekar and Grik5

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_030098003.1
• Gene: Grik5 / 14809
• MGIID: 95818
• Length: 1003
• Species: Mus musculus
• Alignment Length: 939
• Identity: 338/939 - (35%)
• Similarity: 505/939 - (53%)
• Gaps: 123/939 - (13%)

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRF 71
            |:..|.:....|...:|:.||..:|......| ||...|..::|....:..:..|:..:..:.|.
Mouse     9 LIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRD 73

  Fly    72 DSFETVQKVCKLIRVGVQAVFSPTDS-VLATHINSICDALDIPNIGRSAHD---------FSINV 126
            ..:||...:|:::..||.:|..|:.| ..|:.::.||...:||:|.....:         .|:::
Mouse    74 SQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSL 138

  Fly   127 YPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSA 186
            |||.:.|:.|.:.:::..|:....::..|...::.|.:|.|.|     ...|.|...|||. ...
Mouse   139 YPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDP-TPL 202

  Fly   187 LNEFKGKEIHNIIIDTNSN------------------------GISILLKNILQQQMNEYKYHYL 227
            |.|.:..::..||||.|::                        |:|.:|: ..:..|....|.|:
Mouse   203 LKEIRDDKVSTIIIDANASISHLVLRLSLNLSSPLGFPRSLPLGLSCVLQ-ASELGMTSAFYKYI 266

  Fly   228 FTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPY---LNLHIKKST 289
            .|:.|.....|:....:..||..|.:.:|:                |.|...:   ||:..:::.
Mouse   267 LTTMDFPILHLDGIVEDSSNILGFSMFNTS----------------HPFYPEFVRSLNMSWRENC 315

  Fly   290 ILESEP------ALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKG 348
            ...:.|      |||||:|:|....::.|.:|..:.:..::|...|.|..|.||:|||..||:.|
Mouse   316 EASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDG 380

  Fly   349 LTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVGEWTPHGHL--NITEPSMFFDAGSMNVTLVVITI 410
            |||.::|.. |||..:.|.:::..:....::|.|..:..|  |.|...:.......|.||||.||
Mouse   381 LTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTI 445

  Fly   411 LETPYVMMHYGKNF---TGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGM 472
            ||.||||..  .||   :|||||.|||||:|..::..:.|.|.|.||.|..|||.:| .|.|.||
Mouse   446 LENPYVMRR--PNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEP-NGSWTGM 507

  Fly   473 VAQLM-KYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWI 536
            |.:|: :.||||||.:.|||..||.||||:||||.||||||::|........|||::|.:..:|:
Mouse   508 VGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWL 572

  Fly   537 YVLIAYFLVSLCIYIVGKLSPIEW----KCINACD--LENISIGNQFSLTDSFWFTIGTFMQQSP 595
            ::|:||..||..:::..:|||.||    .|:.|..  ||     ||::|.:|.||.:|.||||..
Mouse   573 FMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILE-----NQYTLGNSLWFPVGGFMQQGS 632

  Fly   596 DIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGS 660
            :|.|||:|||.:|..|..|:|||::|||||||||||.:||..|:|:|:|||.||.|.|||:.:||
Mouse   633 EIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGS 697

  Fly   661 TMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQ 725
            |||||::|..:||:::|..|.:|:||.|..:.|:||.||....||||:||||.:|..:.:|||||
Mouse   698 TMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQ 762

  Fly   726 IGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANS 790
            ||||||||||||..|.|||:||:|:||||:|||...:::|..|||:.  ..|.::   :..:|..
Mouse   763 IGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEG--GRCPKE---EDHRAKG 822

  Fly   791 LGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPD 855
            ||:|:|||:|||||.|:|:|..||..||.::.|.:.|   |:.|
Mouse   823 LGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAE---SEEV--------------------- 863

  Fly   856 RSFWIEIAEELRYASWC-----MNKQKRP 879
             |...|:.:|||:|..|     ..:::||
Mouse   864 -SVCQEMLQELRHAVSCRKTSRSRRRRRP 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	100/417 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	200/378 (53%)
		Lig_chan	532..806	CDD:459656	142/279 (51%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	99/418 (24%)
		Periplasmic_Binding_Protein_Type_2	437..808	CDD:473866	200/378 (53%)