Protein Alignment Ekar and Grik3

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001074566.1
• Gene: Grik3 / 14807
• MGIID: 95816
• Length: 919
• Species: Mus musculus
• Alignment Length: 915
• Identity: 353/915 - (38%)
• Similarity: 550/915 - (60%)
• Gaps: 78/915 - (8%)

  Fly     5 SGFLLFQF-LSYGLGVPPLVRIGAIFSNQPG-----MYNSELAFRYAIHRLNMDKSLLPETTVDY 63
            :|||:..| :....|:|.::|||.||....|     |...|.|||::.:.:|.:::|||.||:.|
Mouse    17 AGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTY 81

  Fly    64 YVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIG-RSAH------- 120
            .::.::..||||..:|.|..:.:||.|:|.|:.......:.|||:||::|:|. |..|
Mouse    82 DIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKD 146

  Fly   121 DFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL----SRSFHGEVHMRQVSRD 181
            .|.:|:||....:::|..|::|.|.|....::::...|:|.|.:|    || ::..:.:||:..|
Mouse   147 TFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSR-YNIRLKIRQLPID 210

  Fly   182 SYVS--ALNEFK-GKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKY 243
            |..|  .|.|.| |:|...|...:::....||.:.:....|.|| ||::||:.||...|||.::|
Mouse   211 SDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEY-YHFIFTTLDLYALDLEPYRY 274

  Fly   244 NFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIG 308
            :.||:|.||:::..:..|..|::...:.......:....|   ...::.::.||::|:|::.::.
Mouse   275 SGVNLTGFRILNVDNPHVSAIVEKWAMERLQAAPRAESGL---LDGVMMTDAALLYDAVHIVSVC 336

  Fly   309 LQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLK 371
            .|...|   :|:.::.|....:|..|...:|::...:|:||||.|.|.  .|.|..|.||:|.||
Mouse   337 YQRAPQ---MTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLK 398

  Fly   372 QHSIVKVGEWTPHGHLNITEPSMFFDAGSMNVT-------LVVITILETPYVMMHYG-KNFTGNE 428
            :..:.|||.|:|...|||||.:   .....|||       |:|.|:||.|:||.... :...||:
Mouse   399 EDGLEKVGVWSPADGLNITEVA---KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGND 460

  Fly   429 RFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYA 493
            ||.|:|:|:|:.::..:||.|.:.||.|.||||:| :.|:|||||.:|:.:||||||..:|||:.
Mouse   461 RFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVAPLTITHV 524

  Fly   494 RESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPI 558
            ||..|||:||||.||:|||::.|......:|||:|||:.:||:|||:||..||..::::.:.||.
Mouse   525 REKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPY 589

  Fly   559 EWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYT 623
            ||...:.|:..:..:.|.|:|.:||||.:|:.|||..::.|:|:|||||...|.||:|||::|||
Mouse   590 EWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYT 654

  Fly   624 ANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAF 688
            ||||||||.|||.:||::|:|||.||:|.||.:..|:|||||:.|.|.|::|:|..| :.||||.
Mouse   655 ANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSAL 718

  Fly   689 TTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAI 753
            ....|:||:|....:||.|||||.::||.||:|||||||||:|:|||||.||.|||:||||::||
Mouse   719 VKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAI 783

  Fly   754 LELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEF 818
            |:|||...:.::.:|||:.:.  |..:   :..:|::||::.|||:|:||.||::::.:||..||
Mouse   784 LQLQEEDKLHIMKEKWWRGSG--CPEE---ENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEF 843

  Fly   819 WYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRYASWCMNKQKR----P 879
            .|..|..                     :||.    .|||...:|:|:|::..|..:.|.    |
Mouse   844 IYKLRKT---------------------AERE----QRSFCSTVADEIRFSLTCQRRLKHKPQPP 883

  Fly   880 ALTRT 884
            .:.:|
Mouse   884 MMVKT 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	120/387 (31%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	193/376 (51%)
		Lig_chan	532..806	CDD:459656	137/273 (50%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate	37..417	CDD:380605	120/387 (31%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	190/369 (51%)