Protein Alignment Ekar and Gria2

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001344853.2
• Gene: Gria2 / 14800
• MGIID: 95809
• Length: 901
• Species: Mus musculus
• Alignment Length: 838
• Identity: 299/838 - (35%)
• Similarity: 473/838 - (56%)
• Gaps: 61/838 - (7%)

  Fly    23 VRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIRVG 87
            ::||.:|   |...:.|    |:..|:.|.:....|..:..:::.:...:||......|.....|
Mouse    27 IQIGGLF---PRGADQE----YSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84

  Fly    88 VQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHDFSINVYPSKQLVNYAFNDVIQYLNWT 147
            |.|:|...|......|.|.|..|.:..|..|     .|.|.|.:.|.   :..|...:|:|..|.
Mouse    85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPD---LKGALLSLIEYYQWD 146

  Fly   148 RFGILHEKENGIINLHQLSRSFHGE------VHMRQVSRD----SYVSALNEFKGKEIHNIIIDT 202
            :|..|::.:.|:..|..:..|...:      :::..::.|    :|.|...:.:.|:...:|:|.
Mouse   147 KFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDC 211

  Fly   203 NSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKD 267
            ..:.::.::..::....:...|||:..:......||...::...|::.|::||..|..|.:.::.
Mouse   212 ERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIER 276

  Fly   268 IGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNIS-------C 325
            ...    :.:|.|...|   :..::...||.:|:|.|.....:.|.:..    :.||       |
Mouse   277 WST----LEEKEYPGAH---TATIKYTSALTYDAVQVMTEAFRNLRKQR----IEISRRGNAGDC 330

  Fly   326 EEENS--WDGGLSLINYLNAVEWKGLTGPIQF-KDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHL 387
            ....:  |..|:.:...|..|:.:||:|.|:| ::|:|:.:.:::::||.:...|:|.|:....:
Mouse   331 LANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKM 395

  Fly   388 --NITE-PSMFFDAGSMNVTLVVITILETPYVMMHYGKN---FTGNERFYGFCVDILETISREVG 446
              .:|| ||....:|..|.|:||.||||:|||||.  ||   ..||||:.|:|||:...|::..|
Mouse   396 VVTLTELPSGNDTSGLENKTVVVTTILESPYVMMK--KNHEMLEGNERYEGYCVDLAAEIAKHCG 458

  Fly   447 FDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISI 511
            |.|.|.:|.|.||||:|.:|..|||||.:|:..|||:|:..:|||..||.||||:||||:|||||
Mouse   459 FKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISI 523

  Fly   512 LFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW---KCINACDLENISI 573
            :.|.|......:|||::|||.|||:.::.||..||:.:::|.:.||.||   :..:..:.::...
Mouse   524 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSES 588

  Fly   574 GNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINP 638
            .|:|.:.:|.||::|.||||..||.||::|.||:...|.||:|||::|||||||||||.|||::|
Mouse   589 TNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 653

  Fly   639 IENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQ 701
            ||:||||:.||||:|||||||||..|||.|.|..:.|:|..|.:.:||.|..|..:|:.||  ::
Mouse   654 IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSK 718

  Fly   702 GNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQML 765
            |.||:|:||||.:||.|| .|:..::||.||:|||||||||||..|..::||:|:|.|:|.:..|
Mouse   719 GKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKL 783

  Fly   766 YDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR 823
            .:|||.:..| |..|::..:.|.::|.|.::.|||.:|:.|:.:|.:||..||.|..|
Mouse   784 KNKWWYDKGE-CGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	81/392 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	194/377 (51%)
		Lig_chan	532..806	CDD:459656	133/279 (48%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	81/390 (21%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	196/383 (51%)