Protein Alignment Ekar and Nmdar2

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_061504088.1
• Gene: Nmdar2 / 1275196
• VectorBaseID: AGAMI1_003064
• Length: 910
• Species: Anopheles gambiae
• Alignment Length: 837
• Identity: 197/837 - (23%)
• Similarity: 339/837 - (40%)
• Gaps: 194/837 - (23%)

  Fly   100 ATHINSICDALDIPNIGRSAHD-----------FSINVYPSKQLVNYAFNDVIQYLNWTRFGILH 153
            |.:...:...|.||.|..:|.:           ..:.:.||.:..:.|...:::...|.:|.::.
Mosquito    14 AQYFLQLAGYLGIPVISWNADNSGLERRASQSALQLQLAPSIEHQSAAMLSILERYKWHQFSVVT 78

  Fly   154 EKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQ 218
            .:..|..:..|..|              ..|.|::.||...:::||:...|        ::|:..
Mosquito    79 SQIAGHDDFVQAVR--------------EQVGAMDHFKFTILNSIIVTRPS--------DLLELV 121

  Fly   219 MNEYKYHYLF--TSFDLE----TYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFK 277
            .:|.:...|:  .|..:|    ..:|:....|:|.:.:..:::...             :|..|.
Mosquito   122 NSEARVMLLYCTKSEAIEILHAAEELQITGENYVWVVTQSVIENTQ-------------THPQFP 173

  Fly   278 KPYLNLHIKKST-ILESEPALMFDSVYVFAIGLQ-----TLEQSHSLTLLNISCEEE--NSWDGG 334
            ...|.:|...|: .|.:|.|   .::.|:|.|::     .......|....:|||::  ..||.|
Mosquito   174 IGMLGVHFDTSSGALVNEIA---TAIRVYAYGVEYYLNDVKNTGRRLDTHQLSCEDQGRGRWDSG 235

  Fly   335 LSLINYLNAVEWKGLTGP--IQF-KDGQRVQFKLDLIKLK----QHSIV--KVGEW--------- 381
            .....||..|..:..:..  |:| .||.....:|.::.|:    ...:|  ::|.|
Mosquito   236 EVFFKYLRNVSLESESNKPNIEFTADGDLKSAELKIMNLRPSVNSKGLVWEEIGIWKSWQQQKLD 300

  Fly   382 ------------TPHG-----HLNITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNFTG--- 426
                        .|.|     ||.||    |.:              |.||:.:......:|
Mosquito   301 IRDIAWPGNSHTPPQGVPEKFHLKIT----FLE--------------EAPYINLSPADPVSGKCL 347

  Fly   427 -------------------------NERFY----GFCVDILETISREVGFDYILDLVPDRKYGAK 462
                                     |..||    |||:|:||..:.|:||.|.|..|.|.|:|..
Mosquito   348 MDRGVLCRVAADHEMTDIDMGQAHKNGSFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL 412

  Fly   463 DPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTS--EPTRLFS 525
              |.|:|||::.:|:..|.|:.:.|:.|...||:|:||::|||..||:|:....|.  .||   :
Mosquito   413 --ENGKWNGLIHELVNRKTDMVLTSLMINAEREAVVDFSEPFMETGIAIVVAKRTGIISPT---A 472

  Fly   526 FMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQ-----FSLTDSFWF 585
            |:.|.....|  :|:..|.:....:::   ...||...:..|::.:....|     |||..::|.
Mosquito   473 FLEPFDTASW--MLVGIFAIQAATFMI---FLFEWLSPSGYDMKTVLQNGQTTPYRFSLFRTYWL 532

  Fly   586 TIGTFMQQSPDI-YPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAED----- 644
            ......|.:..: .||..::|.:::.|..|:::.:|.||||||||:.|....:.....:|
Mosquito   533 VWAVLFQAAVHVDSPRGFTSRFMTNVWAMFAVVFLAIYTANLAAFMITREEFHEFTGLDDSRLSH 597

  Fly   645 -LASQTEISYGTLDSGSTMTFFRDSVIETYKK---IWRSMDNKKPSAFTTTYEDGIKRVNQGNY- 704
             .:.:..|.:||:....|     ||.|..|.|   .:....|:...|      ||:..|..|..
Mosquito   598 PFSHKPTIKFGTIPWSHT-----DSTISKYFKEMHYYMKQYNRSSVA------DGVTAVLSGQLD 651

  Fly   705 AFLMESTMLDYIVQR--DCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYD 767
            ||:.:.|:|||:||:  ||.|..:|......|||:|..:.|.:....:..:||.:..||::.|..
Mosquito   652 AFIYDGTVLDYLVQQDEDCRLLTVGQWYAMTGYGLAFSRNSKYVGMFNKRLLEFRANGDLERLRR 716

  Fly   768 KWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRY 824
            .|...   || |....:...::.|.||.....|::|:|||::||::...|..| |:|
Mosquito   717 FWMTG---TC-RPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHLY-FKY 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	63/349 (18%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	114/420 (27%)
		Lig_chan	532..806	CDD:459656	74/291 (25%)
Nmdar2	XP_061504088.1	None