Protein Alignment Ekar and GABA-B-R3

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_061516429.1
• Gene: GABA-B-R3 / 1271397
• VectorBaseID: AGAMI1_005902
• Length: 1106
• Species: Anopheles gambiae
• Alignment Length: 830
• Identity: 135/830 - (16%)
• Similarity: 275/830 - (33%)
• Gaps: 294/830 - (35%)

  Fly    72 DSFETVQKVCKLIRVG--VQAVFSPTDSVLATHINSICDALDIPNIGRSAHDFSINVYPSKQLVN 134
            ||.....::..|:..|  ..|.||..:...:..:|.:...|:..||..:|            .::
Mosquito   196 DSSHHPARIAFLMHFGWDTVATFSQNEEGYSLAVNDLVTELERANITCAA------------TIS 248

  Fly   135 YAFNDVIQYLNWTRFGILHEKENGII---NLHQLSRSFHGEVH--------MRQVSRDSYVSA-- 186
            :|..|..:.|.     :|.:::..:|   ..|:::.....||:        ...:.:|:|:|:
Mosquito   249 FAETDFKEQLK-----LLRDRDVRVIIGSFSHEIAPQVFCEVYNLGMYGAEYAWILQDTYISSWW 308

  Fly   187 ----LNEFKG---------KEIHNIIIDTNSNGI-------SILLKNILQQQMNEYKYHYLFTSF 231
                |.|...         ..:.|:||.::.|.|       |.|..:|..|::.|.......:.|
Mosquito   309 LAGDLPETGSAPCTSRALLTAVENLIIVSSYNSIVGMGTALSGLTNDIFLQKLREMNVTGAVSQF 373

  Fly   232 DLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPA 296
            ..:||
Mosquito   374 APQTY------------------------------------------------------------ 378

  Fly   297 LMFDSVYVFAIGLQTLEQSHSLTL---LNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDG 358
               |:|:..|:.|:..|:|.|.::   :.::..:...:|....|:...:.:::.|::||:.|:..
Mosquito   379 ---DAVWAMALALRGAERSWSQSVPHRVRLADYDYTRYDIAQELLRQFDLLKFNGISGPVSFEGA 440

  Fly   359 QRV-----------QFKLDLIKLKQHSIVKVG-------EWTPHGHLNIT-----------EPSM 394
            .|:           |.::......:::.:..|       .| |.|.:.|.           :|..
Mosquito   441 DRIGTTSFHQIRAGQLEMIAFYYPKNATLDFGCRYCVPIVW-PGGQVPIAKRILRLRVDTIDPFA 504

  Fly   395 FFDAGSMNVTLVVITILETPYVMMHYGKNFTGNERFYGF-----------------CVDILETIS 442
            |:       |:|:::::.....::..|.|.    ||...                 |: ::.|.:
Mosquito   505 FY-------TVVILSLIGIGISVLFLGLNL----RFRKLKAIKLSSPKLSTITVCGCM-LVYTAT 557

  Fly   443 REVGFDYILDLVPDRKYGAKDPETGEWNGM------VAQLMKYKA--DLAVGSM---------TI 490
            ..:|.|:               .|..|:.:      :|::....|  .||.|||         ..
Mosquito   558 ILLGLDH---------------STLPWSSVTFSTICMARIYFLSAGFSLAFGSMFAKTFRVYRIF 607

  Fly   491 TYA-----RESVIDFTKPFMNLGISIL-----------------------FKVPTSEPTRLF--- 524
            |::     |:.::..|:....:|..:|                       .::.|::.:.:|
Mosquito   608 THSAGGLCRDKILRDTQLISVIGALLLVDAFVVSFWMAADPMERHLHNLSLEISTTDRSVVFLPQ 672

  Fly   525 -SFMNPLAIEIWIYVLIAY--FLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFT 586
             ........|.|:.:|.||  .|:.:.:|:..:...::...:|......||:   :|:.    .|
Mosquito   673 VELCRSRHYESWLGMLYAYKGLLLLVGVYMAWQTRNVKISALNDSQYIGISV---YSVV----IT 730

  Fly   587 IGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEI 651
            ..:.:..:..:|.|.....||  |.||    ::.|.||.|....        :...:|:..:.|:
Mosquito   731 SASVVVLANLLYERVTLAFII--TAGF----VLISTTATLCLLF--------LPKIKDIFEKGEV 781

  Fly   652 SYGTLDS-GSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDY 715
            ....:.| |..|.|      .|.:.:   :|:::...|         ||...|..:..|..:||.
Mosquito   782 YDPIIHSMGLKMEF------NTRRFV---LDDRRELQF---------RVEVQNRVYRKELELLDA 828

  Fly   716 IVQR-----------DCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAIL 754
            .:.|           ...|:....|.|::...||.|.||.....:.|::|
Mosquito   829 EICRLERALQERSPQSSPLSSEPNLPDSRPCAIARPHGSSGLPMLLLSVL 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	57/373 (15%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	75/433 (17%)
		Lig_chan	532..806	CDD:459656	49/237 (21%)
GABA-B-R3	XP_061516429.1	None