Protein Alignment Ekar and grik2

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_017949808.1
• Gene: grik2 / 100495093
• XenbaseID: XB-GENE-5902331
• Length: 913
• Species: Xenopus tropicalis
• Alignment Length: 902
• Identity: 360/902 - (39%)
• Similarity: 550/902 - (60%)
• Gaps: 68/902 - (7%)

  Fly    12 FLSYGLGVPPLVRIGAIFSN-QPGMYNS-ELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSF 74
            ::.|..|...::|.|.||.. :.|.:.: |||||:|::.:|.:::|||.||:.|..:.:|.:|||
 Frog    30 WIGYTQGTTHVLRFGGIFEYVESGPFGAEELAFRFAVNTINRNRTLLPNTTLTYDTQRINLYDSF 94

  Fly    75 ETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI-GRSAH-------DFSINVYPSKQ 131
            |..:|.|:.:.:||.|:|.|:.|..|..:.|||:||.:|:| .|..|       .|.:::||...
 Frog    95 EASRKACEQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFS 159

  Fly   132 LVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRS---FHGEVHMRQVSRDSYVS--ALNEFK 191
            .::.|..|::|:..|....|.::...|:|.|.:|.::   ::..:.:||:..|:..:  .|.|.|
 Frog   160 SLSRAILDLVQFFKWKTVTIAYDDSTGLIRLQELIKAPSRYNLRLKIRQLPIDTKDAKPLLKEMK 224

  Fly   192 -GKEIHNIIIDTNSNGISILLKNILQQ-QMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLV 254
             |||.| :|.|.:.:..:.:||..|.. .|.|| |||:||:.||...|:|.::|:.||:|.||::
 Frog   225 RGKEFH-VIFDCSHDMAAGILKQALAMGMMTEY-YHYIFTTLDLFALDVEPYRYSGVNMTGFRIL 287

  Fly   255 DTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLT 319
            :..:..|..|::...:.......||...|   ....:.::.|||:|:|:|.::.:|...|   :|
 Frog   288 NIENSQVLSIIEKWSMERLQAPPKPDSGL---LDGFMTTDAALMYDAVHVVSVAVQQFPQ---MT 346

  Fly   320 LLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLKQHSIVKVGEWT 382
            :.::.|.....|..|...|:.:....|:||||.|.|.  :|.|..|.||:|.||:..:.|:|.|.
 Frog   347 VSSLQCNRHKPWRFGARFISLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWD 411

  Fly   383 PHGHLNITE-----PSMFFDAGSMNVTLVVITILETPYVMMHYG-KNFTGNERFYGFCVDILETI 441
            |...||:||     |:...|:.| |.:|:|.||||.||||.... |...|..||.|:|:|:||.:
 Frog   412 PTSGLNMTENQKGKPANITDSLS-NRSLIVTTILEEPYVMFKKSDKPLYGKARFEGYCIDLLEKL 475

  Fly   442 SREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMN 506
            |:.:||:|.:.||.|.||||||..|.:|||||.:||.:||||||..:.|||.||.|||||||||.
 Frog   476 SKILGFEYEVRLVEDGKYGAKDDTTQQWNGMVRELMDHKADLAVAPLAITYVREQVIDFTKPFMT 540

  Fly   507 LGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENI 571
            ||||||::.|......:|||:|||:.:||:|:|:||..||..::::.:.||.||...:.|:.::.
 Frog   541 LGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD 605

  Fly   572 SIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMI 636
            .:.|.|:|.:||||.:|..|||..::.|:|:||||:...|.||:|||::|||||||||||.|||.
 Frog   606 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERME 670

  Fly   637 NPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQ 701
            :||::|:|||.||:|.||.:..|:|||||:.|.|.||:|:|..|:::..|......|:||:||..
 Frog   671 SPIDSADDLAKQTKIEYGAVQDGATMTFFKKSRIPTYEKMWAFMNSRSQSVLVKNNEEGIQRVLT 735

  Fly   702 GNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLY 766
            .:||||||||.::::.||:|||||||||:|:||||:.||.|||:||||::|||:|||.|.:.|:.
 Frog   736 SDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGVLHMMK 800

  Fly   767 DKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPS 831
            :|||:...  |..:   :..:|::||:::|||:|:||.||::::..||..||.|
 Frog   801 EKWWRGNG--CPEE---ESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY----------- 849

  Fly   832 QSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRYASWCMNKQKR----PALTRT 884
                          :|::|.....|||...:.||||.:..|..:.|.    |.:.:|
 Frog   850 --------------KSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQPPVIVKT 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	125/384 (33%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	197/369 (53%)
		Lig_chan	532..806	CDD:459656	134/273 (49%)
grik2	XP_017949808.1	PBP1_iGluR_Kainate	42..419	CDD:380605	125/384 (33%)
		Periplasmic_Binding_Protein_Type_2	435..805	CDD:473866	197/369 (53%)