Protein Alignment Ekar and grin2b

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 888
• Identity: 211/888 - (23%)
• Similarity: 366/888 - (41%)
• Gaps: 181/888 - (20%)

  Fly    44 YAIHRLNMDKS-LLPETTVDYYVEYVNRFDSF--------------------ETVQKVCKLIR-V 86
            ||....|||.: :|..||.:..::.|:..|.|                    ..:.::|.|:. .
 Frog    23 YAQKHPNMDIAVILVGTTDEVAIKDVHEKDDFHHLPVTPRVALVTMNESDPKSIITRICDLMSDK 87

  Fly    87 GVQAVFSPTDSVLATHINSICDALDI-------PNIGRSAHDFSINVYPSKQLVNYAFN------ 138
            .||.|....|    |...:|...||.       |.:|  .|..|..:...|:..:..|.
 Frog    88 KVQGVVFGDD----TDQEAIAQILDFISVQTLTPILG--IHGGSSMIMADKEEASMFFQFGPSIE 146

  Fly   139 -------DVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEFKGKEIH 196
                   ::::..:|..|.|:.....|..:.....||                :..|.|.|.|:.
 Frog   147 QQASVMLNIMEEYDWYIFSIVTTYFPGYQDFENKVRS----------------TIENSFVGWELE 195

  Fly   197 NII-----IDTNSNGISILLKNILQQQMNEY----KYHYLFTSFDLETYDLEDFKYNFVNITSFR 252
            .:|     :|.|.:.|...||.:....:..|    :..|:|..  ..:..|..:.|.:: :.|..
 Frog   196 EVIHLDMSLDDNDSKIQNQLKKLQSPVILLYCTKEEATYIFEV--AHSVGLTGYGYTWI-VPSLV 257

  Fly   253 LVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSH- 316
            ..||..|..:   ...||.|....:..|            ..||.:.|.:.:......|:...|
 Frog   258 AGDTDTVPAE---FPTGLISVSYDEWDY------------DLPARVRDGIAIITTAASTMLSEHN 307

  Fly   317 SLTLLNISC---EEENSWDGGLSLINYLNAVEWKGLTGPIQF-KDGQRVQFKLDLIKLKQHSIVK 377
            |:.....||   :|...::..: |..||..|.::|..  :.| :||.::..||.:|.|.|..
 Frog   308 SIPQSKSSCYNIQESRVYEAHM-LKRYLINVTFEGRN--LSFSEDGYQMHPKLVIILLNQQR--- 366

  Fly   378 VGEWTPHGHLNITEPSMFF-----------DAGSMNVTLVVITILETPYVMMH------------ 419
              :|...|........|.:           .....:..|.::|:.|.|:|::.
 Frog   367 --KWERVGKYKDRSLKMKYYVWPVFELYPNSEEHKDEHLSIVTLEEAPFVIVEDVDPLSGTCMRN 429

  Fly   420 --------YGKNFTGNERFY------GFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWN 470
                    ..:|.|.....|      |||:|||:.|::.|.|.|.|.||.:.|:|.|  ..|.||
 Frog   430 TVPCRKQIRTENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKK--INGTWN 492

  Fly   471 GMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVP--TSEPTRLFSFMNPLAIE 533
            ||:.:::..:|.:||||:||...|..|:||:.||:..|||::....  |..|:   :|:.|.:.:
 Frog   493 GMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS---AFLEPFSAD 554

  Fly   534 IWIYVLIAYFLVS-LCIYIVGKLSPIEWKCINACDLENISIGN-QFSLTDSFWFTIG-TFMQQSP 595
            :|:.:.:...:|| :.:::....||:.:   |.|..:....|. .|::..:.|...| .|....|
 Frog   555 VWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVP 616

  Fly   596 DIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQ------TEISYG 654
            ...|:..:::|:.|.|.||::|.:||||||||||:..|..::.:....|...|      ....:|
 Frog   617 VQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFG 681

  Fly   655 TLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNY-AFLMESTMLDYIVQ 718
            |:.:|||....|::.:|.:..:.:.  |::      :.:|.:..:..|.. ||:.::.:|:|:..
 Frog   682 TVPNGSTERNIRNNYLEMHSYMVKF--NQR------SVQDALLSLKTGKLDAFIYDAAVLNYMAG 738

  Fly   719 RD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTR 779
            ||  |.|..||.  :..|.|||||..|.|.|:.::.||||:|...|:::.|...|.     |...
 Frog   739 RDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL-----TGIC 798

  Fly   780 KNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFE---FW 819
            .|...:..::.|.::::.|||.:|.|.:.::.:....|   ||
 Frog   799 HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFFW 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	80/401 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	119/410 (29%)
		Lig_chan	532..806	CDD:459656	77/287 (27%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	79/402 (20%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	120/420 (29%)
		NMDAR2_C	837..1449	CDD:463148	2/5 (40%)