Protein Alignment Ekar and grin2a

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_031749422.1
• Gene: grin2a / 100489006
• XenbaseID: XB-GENE-992741
• Length: 1450
• Species: Xenopus tropicalis
• Alignment Length: 1003
• Identity: 242/1003 - (24%)
• Similarity: 410/1003 - (40%)
• Gaps: 215/1003 - (21%)

  Fly     8 LLFQFLSY----GLGVP---PLVRIGAIFSNQPGMYNSELAFRYAIHR-----LNMDKSLLPETT 60
            ||...|.|    |.|..   |::.|..|....          ||...|     ...|.||  :..
 Frog     6 LLLYTLLYAGDLGQGAEKSFPVLNIAVILGRT----------RYITERDIRSLWTRDMSL--DFD 58

  Fly    61 VDYYVEYVNRFDSFETVQKVCKLIRVGVQ---AVF-SPTD-SVLATHINSICDALDIPNIGRSAH 120
            |:.....||:.|....:..||.|:. |.:   .|| ..|| ..:|..::.:.....||.:|  .|
 Frog    59 VNVVTLLVNQTDPKSIITHVCDLMS-GTKIHGVVFGDDTDQEAIAQILDFVSSQTFIPILG--IH 120

  Fly   121 DFSINVYPSKQLVNYAFN-------------DVIQYLNWTRFGILHEKENGIINLHQLSRSFHGE 172
            ..|..:...|..::..|.             ::::..:|..|.|             ::.:|.|
 Frog   121 GGSSMIMADKDEMSTFFQFGASIKQQAIVMLNIMEEYDWHVFSI-------------ITSTFPG- 171

  Fly   173 VHMRQVSRD--SYVSAL--NEFKGKEIHNII-IDTNSNGISIL--LKNILQQQMNEY----KYHY 226
                  .||  |::...  |.|.|.|:.|:| :||:......|  ||.|....:..|    :.:|
 Frog   172 ------YRDFISFIKTTVDNSFVGWEVQNVITLDTSYTDARTLTQLKKIHSSVILLYCSKDEANY 230

  Fly   227 LFTSFDLETYDLEDFKYNFVNITSFRLVDTADV-------GVKQILKDIGLYSHHIFKKPYLNLH 284
            :|    :|...|....|.||.|....:....|:       |:..:..|...|:
 Frog   231 IF----VEARSLGLMGYGFVWIVPSLVTGNTDIIPYEFPSGLVSVSYDDWDYN------------ 279

  Fly   285 IKKSTILESEPALMFDSVYVFAIGLQTLEQSHS-LTLLNISCEEENSWDGG--LSLINYLNAVEW 346
                  :|   |.:.|.:.:.......:.:.|| :.....||..:|..:..  .:|..::..|.|
 Frog   280 ------IE---ARVRDGLGIITTAASAMLEKHSVIPEAKTSCYAQNERNEPPLHTLHKFMINVTW 335

  Fly   347 KGLTGPIQF-KDGQRVQFKLDLIKLK-QHSIVKVGEWTPHGHLNITEP-----SMFFDAGSMNVT 404
            .|  ..:.| :||.:...||.::.|. .....|||:| .:..||:..|     :...|:...:..
 Frog   336 DG--KDLSFTEDGYQANPKLVVLLLNMDREWEKVGKW-ENKSLNMKYPVWPRITASLDSDPDDNH 397

  Fly   405 LVVITILETPYVMMHYGKNFTGN--------ERFY-----------------GFCVDILETISRE 444
            |.::|:.|.|:|::......||.        .:::                 |||:|||:.:|:.
 Frog   398 LSIVTLEEAPFVIVENVDYLTGTCVRNTVPCRKYFRLNNSTTEGTSVKKCCKGFCIDILKKLSKT 462

  Fly   445 VGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGI 509
            |.|.|.|.||.:.|:|.|....  ||||:.:::..:|.:||||:||...|...:||:.||:..||
 Frog   463 VKFTYDLYLVTNGKHGKKIKNV--WNGMIGEVVYKRAVMAVGSLTINEERSEAVDFSVPFVETGI 525

  Fly   510 SILFKVP--TSEPTRLFSFMNPLAIEIWIYVLIAYFLVS-LCIYIVGKLSPIEWKCINACDLENI 571
            |::....  |..|:   :|:.|.:..:|:.:.:...||| :.:::....||:.:.       .|:
 Frog   526 SVMVSRSNGTVSPS---AFLEPFSASVWVMMFVMLLLVSAVAVFVFEYFSPVGYN-------RNL 580

  Fly   572 SIGN-----QFSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFL 630
            :.|.     .|::..:.|...| .|....|...|:..:::||.|.|.||::|.:||||||||||:
 Frog   581 ADGKAPHGPSFTIGKAVWLLWGLVFNNSVPVQNPKGTTSKIIVSIWAFFAVIFLASYTANLAAFM 645

  Fly   631 TTERMINPIENAEDLASQTEISY------GTLDSGSTMTFFRDS-------VIETYKKIWRSMDN 682
            ..|..::.:....|...|....|      ||:.:|||....|::       :::.::|
 Frog   646 IQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPDMHQYMVKFHQK------- 703

  Fly   683 KKPSAFTTTYEDGIKRVNQGNY-AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIATPKG 742
                    ..:|.:..:..|.. ||:.::.:|:|:..||  |.|..||.  :..|.|||||..||
 Frog   704 --------GVQDALVSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIALQKG 760

  Fly   743 SPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGI 807
            |.|:..|.||:|:....|:::.| :|.|. |....|.||   :..::.|.::::.|||.:|.|.:
 Frog   761 SRWKRPIDLALLQFVGDGEMEEL-EKLWL-TGICHTEKN---EVMSSQLDIDNMAGVFYMLAAAM 820

  Fly   808 IVAAVVAFFE--FWYNFRYNY----EATPSQ--SVVNNKYNQDGILESERNYTPPDRSFWIEIAE 864
            .::.:...:|  |::..||.:    ..||..  |:....|:....:..|.....||.||......
 Frog   821 ALSLITFVWEHLFYWKLRYCFTGVCTGTPGLLFSISRGIYSCIHGVHIEEKKKSPDFSFTASQTN 885

  Fly   865 ELRYASWCMNKQKRPALTRTCSKCTIPK 892
            .|:......|......|.:  |:|..||
 Frog   886 MLKLLRASKNIANLSNLNQ--SQCNSPK 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	85/411 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	117/420 (28%)
		Lig_chan	532..806	CDD:459656	81/298 (27%)
grin2a	XP_031749422.1	PBP1_iGluR_NMDA_NR2	26..379	CDD:380601	86/415 (21%)
		PBP2_iGluR_NMDA_Nr2	395..793	CDD:270436	119/426 (28%)
		NMDAR2_C	831..1450	CDD:463148	19/83 (23%)